Jeremy Farrar: When disaster strikes

The number of controlled human infection models (CHIMs) conducted worldwide has increased considerably in recent years, although few have been conducted in low and middle-income countries (LMICs), where infectious diseases have the greatest burden. Recently Oxford University Clinical Research Unit (OUCRU) in Ho Chi Minh City (HCMC) started developing CHIM research proposals motivated by the need to develop a clearer and more grounded understanding of the issues surrounding the conduct of CHIMs in LMICs. To explore initial perceptions and barriers to conducting CHIMs in Vietnam, OUCRU researchers conducted a set of key stakeholder interviews early in 2018 and held a CHIM workshop in HCMC in March 2018. This paper summarizes the discussions from the workshop and outlines a way forward for conducting CHIMs in Vietnam.

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New technologies to improve healthcare in low- and middle-income countries: Global Grand Challenges satellite event, Oxford University Clinical Research Unit, Ho Chi Minh City, 17th-18th September 2019

Wellcome Open Research ◽

10.12688/wellcomeopenres.16008.1 ◽

2020 ◽

Vol 5 ◽

pp. 142

Author(s):

Minh Ngoc Dinh ◽

Joseph Nygate ◽

Van Hoang Minh Tu ◽

C. Louise Thwaites ◽

Keyword(s):

New Technologies ◽

Research Unit ◽

Ho Chi Minh City ◽

Middle Income ◽

Grand Challenges ◽

Middle Income Countries ◽

Oxford University ◽

Key Stakeholders ◽

Clinical Research Unit ◽

Low And Middle Income

We report the outputs of a satellite event in Ho Chi Minh City, Vietnam, organized as part of the “2nd Global Grand Challenges of Engineering Summit”. The event considered challenges and potential solutions for improving low- and middle-income country (LMIC) healthcare systems, with particular reference to critical care. Participants from key regional and local stakeholders in healthcare and engineering discussed how new advances in technology, especially in the field of Artificial Intelligence, could be of potential benefit. This article summarizes the perspectives and conclusions of a group of key stakeholders from LMICs across South and South East Asia.

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Oxford University Clinical Research Unit (OUCRU)

Wellcome Open Research Channels ◽

10.12688/wellcomeopenres.channels.185 ◽

2018 ◽

Keyword(s):

Clinical Research ◽

Research Unit ◽

Oxford University ◽

Clinical Research Unit

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New technologies to improve healthcare in low- and middle-income countries: Global Grand Challenges satellite event, Oxford University Clinical Research Unit, Ho Chi Minh City, 17th-18th September 2019

Wellcome Open Research ◽

10.12688/wellcomeopenres.16008.2 ◽

2020 ◽

Vol 5 ◽

pp. 142

Author(s):

Minh Ngoc Dinh ◽

Joseph Nygate ◽

Van Hoang Minh Tu ◽

C. Louise Thwaites ◽

Keyword(s):

New Technologies ◽

Research Unit ◽

Ho Chi Minh City ◽

Middle Income ◽

Grand Challenges ◽

Middle Income Countries ◽

Oxford University ◽

Key Stakeholders ◽

Clinical Research Unit ◽

Low And Middle Income

We report the outputs of a satellite event in Ho Chi Minh City, Vietnam, organized as part of the “2nd Global Grand Challenges of Engineering Summit”. The event considered challenges and potential solutions for improving low- and middle-income country (LMIC) healthcare systems, with particular reference to critical care. Participants from key regional and local stakeholders in healthcare and engineering discussed how new advances in technology, especially in the field of Artificial Intelligence, could be of potential benefit. This article summarizes the perspectives and conclusions of a group of key stakeholders from LMICs across South and South East Asia.

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Comparison of actigraphy and polysomnography to assess effects of zolpidem in a clinical research unit

Sleep Medicine ◽

10.1016/j.sleep.2011.12.003 ◽

2012 ◽

Vol 13 (4) ◽

pp. 419-424 ◽

Cited By ~ 32

Author(s):

Barry T. Peterson ◽

Ping Chiao ◽

Eve Pickering ◽

Jon Freeman ◽

Gary K. Zammit ◽

...

Keyword(s):

Clinical Research ◽

Research Unit ◽

Clinical Research Unit

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Referrals for panic disorder to a clinical psycho-pharmacology research unit

Psychiatric Bulletin ◽

10.1192/pb.17.7.416 ◽

1993 ◽

Vol 17 (7) ◽

pp. 416-417 ◽

Cited By ~ 3

Author(s):

Luiz Dratcu ◽

Alyson Bond

Keyword(s):

Panic Disorder ◽

Clinical Research ◽

Research Unit ◽

Clinical Population ◽

Constant Flow ◽

Research Projects ◽

Clinical Research Unit

Clinical research attempts to find out the best way to treat patients and audit attempts to make sure that patients are treated in the best possible way. The two are thus inextricably linked and should benefit from each other (Smith, 1992). In running a clinical research unit in which the personnel involved (two psychiatrists and two psychologists) have only honorary contracts, it is sometimes difficult to match the service offered to the clinical population required. A constant flow of patients does not mean a constant flow of those prepared or suitable to participate in research projects. Unlike clinical referrals, which are received passively, referrals of patients for research have to be looked for, even when treatment is on offer.

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4079 Lessons learned from implementing Quality Improvement (QI) in academic clinical research setting

Journal of Clinical and Translational Science ◽

10.1017/cts.2020.241 ◽

2020 ◽

Vol 4 (s1) ◽

pp. 74-74

Author(s):

Chin Chin Lee ◽

DUSHYANTHA JAYAWEERA ◽

Marjorie Godfrey ◽

Matthias Salathe ◽

Jonelle Wright ◽

...

Keyword(s):

Quality Improvement ◽

Clinical Research ◽

Research Unit ◽

Lessons Learned ◽

Research Teams ◽

Team Members ◽

Clinical Research Unit ◽

Study Population ◽

Survey Results ◽

The University

OBJECTIVES/GOALS: We describe here the implementation of a pilot Quality Improvement (QI) program in clinical research processes in order to facilitate translation from bench to community. This presentation will also discuss challenges encountered by the research teams during the implementation of QI activities. METHODS/STUDY POPULATION: Miami CTSI collaborated with University of Kansas’ CTSA to test the implementation of a QI program for clinical research processes. The program has a duration of 1 year and consists of multi-modal training and coaching sessions with different research teams. Six teams comprising of Principal investigators, clinical coordinators, and regulatory specialists participated in the program based in applied clinical microsystem theory science. Team coaches and teams worked together to assess current processes, test new and improved processes, and standardize and disseminate applicable best practices of the QI program. RESULTS/ANTICIPATED RESULTS: The implementation of QI activities in large clinical research settings poses numerous challenges for the research team. We will present survey results from the coaching sessions and follow on feedback from the different teams involved in the program to implement the QI activities. We will describe the modifications and adjustments made to the original conceptual framework of QI program in order for it to be applicable and feasible for the settings of the University of Miami. We will provide recommendations for other academic clinical research centers that are considering implementing a QI program. DISCUSSION/SIGNIFICANCE OF IMPACT: The successful adaptation of a QI process to implement in academic clinical research settings relies on early engagement of the institution leadership, careful selection of team members, as well as developing communication skills to enhance team dynamics as a clinical research unit.

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