scholarly journals THE PRODUCTION AND SIGNIFICANCE OF CUTANEOUS ALLERGY TO PNEUMOCOCCUS PROTEIN

1925 ◽  
Vol 41 (1) ◽  
pp. 65-71 ◽  
Author(s):  
George M. Mackenzie ◽  
Shutai T. Woo

1. Intracutaneous injection of guinea pigs with an alkaline extract of pneumococcus produces in about two-thirds of the animals an allergy with a skin reaction similar to the allergic skin response of tuberculosis. 2. Continuance of the intracutaneous injections after the appearance of allergy results in its disappearance. The skin ceases to react. 3. Neither the animals manifesting skin allergy nor those which fail to develop it show any significant alteration in susceptibility to pneumococcus infection by intraperitoneal inoculation. Similarly, animals desensitized by continuing the intracutaneous injections after the appearance of allergy show an unaltered susceptibility.

1930 ◽  
Vol 51 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Claus W. Jungeblut ◽  
Gladys Newnan

1. Guinea pigs blocked by intravenous injection of either India ink or trypan blue succumbed with fatal shock after the intravenous injection of heterophile immune serum, although the time of death was somewhat delayed as compared with normal controls. 2. Local blockade of the skin of guinea pigs with trypan blue inhibited completely the development of the characteristic skin reaction following intracutaneous injection of Forssman serum within the blocked area. 3. Infiltration of the skin of guinea pigs with India ink afforded no protection against the full development of the toxic skin reaction.


1931 ◽  
Vol 53 (4) ◽  
pp. 511-526 ◽  
Author(s):  
Francis D. W. Lukens ◽  
Warfield T. Longcope

1. Both focal and diffuse glomerulitis has been produced in rabbits by the injection directly into the left renal artery of suspensions of heat killed hemolytic streptococci. 2. Similar lesions in the glomeruli could not be obtained by the injection of suspensions of bismuth oxychloride into the left renal artery of normal rabbits. 3. The acute glomerulitis occurred in only about one-half of the rabbits employed for the experiments. 4. Glomerulitis was observed much more frequently in rabbits in which an acute localized streptococcus infection had been produced by the intracutaneous injection of living hemolytic streptococci, than in normal rabbits. The occurrence of acute glomerulitis was usually associated with a well marked skin reaction to the filtrates of hemolytic streptococci.


Medicina ◽  
2007 ◽  
Vol 43 (9) ◽  
pp. 679
Author(s):  
Gryta Laurynaitytė ◽  
Asta Lignugarienė ◽  
Skaidra Valiukevičienė

This year we celebrate the 110th anniversary of Bronius Sidaravičius’s (1897–1969) birth. He was a renowned Lithuanian dermato-venereologist, professor, head of the Department of Skin and Venereal Diseases at Vytautas Magnus University (1935–1946, 1956–1969), the founder and the chair of the Lithuanian Society of Dermato-venereologists, coeditor of the prewar journal “Medicina.” He is an author of more than 100 articles and the very first course book on dermato-venereology in Lithuanian. He completed a part of his medical studies at universities in Germany. In Vienna University (1930), B. Sidaravičius performed clinical and experimental studies on the passive transmission of skin allergy, which had a major impact on the diagnostics of allergic skin diseases and specific desensibilization. He published the results of his study in the foreign literature and in the doctoral dissertation “Skin allergy and its treatment” in 1931. Thanks to the efforts of B. Sidaravičius and his colleagues, a progressive Law on Control and Prevention of Venereal Diseases was enacted in Lithuania. According to this Law, examinations and treatment of venereal diseases became compulsory and free of charge at state- or municipality-financed venereal outpatient units. This article was prepared on the basis of primary sources: protocols of the Council (the Faculty of Medicine, the University of Lithuania; since 1930 – Vytautas Magnus University) kept at the Museum of the History of Lithuania Medicine and Pharmacy as well as documents preserved at the Lithuanian State Archives and also scientific journals and periodicals both in Lithuanian and foreign languages.


2020 ◽  
Author(s):  
Marion Sallée ◽  
Lucile Mercadal ◽  
Guillaume Jean ◽  
Bruno Guery ◽  
Didier Borniche ◽  
...  

Abstract Background We report the results of an observational study of arteriovenous fistula (AVF) cannulation and haemostasis practices in France. Methods The study (sponsored by Brothier Pharmaceutical Inc.) was conducted in 150 dialysis units. Data obtained from 150 supervisory nurses, 1538 nurses and 3588 patients with an AVF were analysed. Results The nurses reported using rope-ladder, area or buttonhole cannulation techniques in 68, 26 and 6% of cases, respectively. Metal needles were used most frequently (64%), with mainly a diameter of 15 G or 16 G. The needle was introduced with the bevel up in 56% of cases. Compression applied using dressings (in particular, pure calcium alginate dressings) was the method of choice for haemostasis of the puncture sites and was assessed as being strong by most of the nurses and very strong in cases of prolonged bleeding. Most (82%) of the patients reported the use of local anaesthetic before cannulation and 23% reported an allergic skin reaction to the anaesthetic. Bleeding of the puncture sites lasted for >10 min for 48% of the patients and it reappeared between two sessions for 29% of the patients. Whereas the nurses appeared to have a good understanding of AVF, more than half of the patients did not know how to care for it, with 55% requiring more information. Conclusions This study underlines the lack of national consensus concerning AVF cannulation practices. It suggests that haemostasis methods of the puncture sites can be improved and it highlights the need to improve patient knowledge.


2009 ◽  
Vol 21 (4p2) ◽  
pp. e780-e786 ◽  
Author(s):  
Betty C. A. M. Van Esch ◽  
Bastiaan Schouten ◽  
Gerard A. Hofman ◽  
Ton Van Baalen ◽  
Frans P. Nijkamp ◽  
...  

1927 ◽  
Vol 26 (2) ◽  
pp. 204-212 ◽  
Author(s):  
Harry Schütze ◽  
S. S. Zilva

Guinea-pigs living on a diet restricted in quantity but not deficient in vitamin C survived inoculation with T.B. but half as long as others which had received a similar diet in abundance.Sodium chaulmoograte did not inhibit the development of the omental tumour that appears in rats after intraperitoneal inoculation with tubercle bacilli.On the other hand, there was some evidence for assuming that a large excess of fat-soluble vitamins in the diet, as supplied by cod-liver oil, inhibits the formation in rats of these tuberculous tumours, but such evidence was by no means conclusive.Similar inhibition of omental infection was obtained on exposing rats to ultra-violet light.Ultra-violet irradiation or the inclusion of large amounts of cod-liver oil in the diet of the rats produced a slight but constant leucocytosis.No evidence was obtained that lack of fat soluble vitamins in their diet renders tubercle infected rats susceptible to tuberculin shock.


The Lancet ◽  
1932 ◽  
Vol 220 (5692) ◽  
pp. 729-731 ◽  
Author(s):  
H.J. Gibson ◽  
J.P. Mcgibbon

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