scholarly journals THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY

1930 ◽  
Vol 51 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Claus W. Jungeblut ◽  
Gladys Newnan
Keyword(s):  
Skin Reaction ◽  
Intravenous Injection ◽  
Guinea Pigs ◽  
Trypan Blue ◽  
Immune Serum ◽  
India Ink ◽  
Intracutaneous Injection ◽  
Toxic Skin ◽  
Normal Controls ◽  
Reticulo Endothelial System

1. Guinea pigs blocked by intravenous injection of either India ink or trypan blue succumbed with fatal shock after the intravenous injection of heterophile immune serum, although the time of death was somewhat delayed as compared with normal controls. 2. Local blockade of the skin of guinea pigs with trypan blue inhibited completely the development of the characteristic skin reaction following intracutaneous injection of Forssman serum within the blocked area. 3. Infiltration of the skin of guinea pigs with India ink afforded no protection against the full development of the toxic skin reaction.

scholarly journals THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY

1926 ◽  
Vol 44 (1) ◽  
pp. 129-145 ◽  
Author(s):  
C. W. Jungeblut ◽  
J. A. Berlot
Keyword(s):  
Intravenous Injection ◽  
Normal Control ◽  
Guinea Pigs ◽  
Anaphylactic Shock ◽  
India Ink ◽  
Passive Sensitization ◽  
Normal Controls ◽  
Reticulo Endothelial System

1. Guinea pigs injected intravenously with massive doses of India ink before active sensitization exhibited occasionally a more or less marked, decreased sensitiveness to the reinjection of the antigen. 2. The serum of rabbits which had received massive doses of India ink before the sensitizing injections, showed approximately the same titer of anaphylactic antibodies as that of sensitized normal control animals, as demonstrated by the degree of passive sensitization induced in guinea pigs. 3. The precipitin titer of sensitized rabbits blocked with massive doses of India ink was somewhat lower than that of sensitized normal controls. In one instance, the intravenous injection of smaller doses of India ink was followed by a higher precipitin titer. No uniform relation was found between the height of the precipitin titer and the anaphylactic power of the antiserums. 4. One blocking injection of India ink given to guinea pigs before passive sensitization did not interfere with the occurrence of anaphylactic shock nor alter its nature.

scholarly journals THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY

1930 ◽  
Vol 51 (1) ◽  
pp. 5-14 ◽  
Author(s):  
Claus W. Jungeblut ◽  
Barbara R. McGinn
Keyword(s):  
Single Dose ◽  
Intravenous Injection ◽  
Guinea Pigs ◽  
Single Injection ◽  
Arsenic Content ◽  
Experimental Conditions ◽  
Normal Organ ◽  
India Ink ◽  
Normal Controls ◽  
Reticulo Endothelial System

1. Blockade of the reticulo-endothelial system by means of a single injection of India ink caused a marked retention of neoarsphenamine in the blood of guinea pigs during the first twenty minutes of observation after intravenous injection, as contrasted with the rapid disappearance of the drug from the blood of normal controls. 2. Rabbits blocked by a single dose of India ink showed a slower elimination of the drug from the circulation following the first few hours after intravenous injection than corresponding controls. 3. The arsenic content of the liver of mice, which received neoarsphenamine intravenously after a preceding blocking injection with India ink, was appreciably lower than the arsenic content of the normal organ under similar experimental conditions.

RETICULO-ENDOTHELIAL SYSTEM STIMULATING COMPOUNDS AND THEIR MECHANISM OF ACTION

1958 ◽  
Vol 36 (1) ◽  
pp. 319-326 ◽  
Author(s):  
B. Gözsy ◽  
L. Kátó
Keyword(s):  
Trypan Blue ◽  
Chemical Structure ◽  
Linalyl Acetate ◽  
Experimental Tuberculosis ◽  
Active Compounds ◽  
Citronellyl Acetate ◽  
India Ink ◽  
Reticulo Endothelial System

A series of compounds are described which exhibit therapeutic activity in experimental tuberculosis, acting exclusively on the host. The active compounds (citronellyl acetate, d-limonen, linalyl acetate) induce a local India ink and trypan blue accumulation and also stimulate the macrophages in vitro and in vivo to an increased phagocytic activity. Sera of the animals treated with therapeutically active compounds stimulate the macrophages of normal animals to an increased phagocytosis. A correlation between chemical structure of the reticulo-endothelial system stimulating compounds and the above effects is discussed.

scholarly journals THE PRODUCTION AND SIGNIFICANCE OF CUTANEOUS ALLERGY TO PNEUMOCOCCUS PROTEIN

1925 ◽  
Vol 41 (1) ◽  
pp. 65-71 ◽  
Author(s):  
George M. Mackenzie ◽  
Shutai T. Woo
Keyword(s):  
Skin Reaction ◽  
Guinea Pigs ◽  
Significant Alteration ◽  
Alkaline Extract ◽  
Skin Allergy ◽  
Skin Response ◽  
Allergic Skin ◽  
Intracutaneous Injection ◽  
Intraperitoneal Inoculation

1. Intracutaneous injection of guinea pigs with an alkaline extract of pneumococcus produces in about two-thirds of the animals an allergy with a skin reaction similar to the allergic skin response of tuberculosis. 2. Continuance of the intracutaneous injections after the appearance of allergy results in its disappearance. The skin ceases to react. 3. Neither the animals manifesting skin allergy nor those which fail to develop it show any significant alteration in susceptibility to pneumococcus infection by intraperitoneal inoculation. Similarly, animals desensitized by continuing the intracutaneous injections after the appearance of allergy show an unaltered susceptibility.

scholarly journals THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY

1926 ◽  
Vol 43 (6) ◽  
pp. 797-806 ◽  
Author(s):  
C. W. Jungeblut ◽  
J. A. Berlot
Keyword(s):  
Methylene Blue ◽  
Guinea Pig ◽  
Guinea Pigs ◽  
Full Extent ◽  
Intravenous Injections ◽  
India Ink ◽  
Normal Functional ◽  
Reticulo Endothelial System ◽  
Pig Serum

1. Intravenous injections of India ink into guinea pigs caused a decided drop in the complement titer which set in as early as 15 minutes after the injection, but did not reach its maximum for 3 hours. This drop was followed by a return to normal within the first 24 hours following the injection. 2. India ink mixed in vitro with guinea pig serum adsorbs the complement almost immediately to its full extent. 3. By means of reduction tests (methylene blue and nitroanthraquinone) it was shown that the respiration of the cells of the liver and spleen of guinea pigs was markedly impaired for the first 8 hours, following an intravenous injection of ink. Evidences of a return to normal functional vitality, however, became apparent by the end of the 1st day after the injection.

RETICULO-ENDOTHELIAL SYSTEM STIMULATING COMPOUNDS AND THEIR MECHANISM OF ACTION

1958 ◽  
Vol 36 (3) ◽  
pp. 319-326 ◽  
Author(s):  
B. Gözsy ◽  
L. Kátó
Keyword(s):  
Trypan Blue ◽  
Chemical Structure ◽  
Linalyl Acetate ◽  
Experimental Tuberculosis ◽  
Active Compounds ◽  
Citronellyl Acetate ◽  
India Ink ◽  
Reticulo Endothelial System

A series of compounds are described which exhibit therapeutic activity in experimental tuberculosis, acting exclusively on the host. The active compounds (citronellyl acetate, d-limonen, linalyl acetate) induce a local India ink and trypan blue accumulation and also stimulate the macrophages in vitro and in vivo to an increased phagocytic activity. Sera of the animals treated with therapeutically active compounds stimulate the macrophages of normal animals to an increased phagocytosis. A correlation between chemical structure of the reticulo-endothelial system stimulating compounds and the above effects is discussed.

scholarly journals THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY

1927 ◽  
Vol 46 (4) ◽  
pp. 609-614 ◽  
Author(s):  
C. W. Jungeblut
Keyword(s):  
Guinea Pig ◽  
Intravenous Injection ◽  
Diphtheria Toxin ◽  
Minimum Amount ◽  
Lethal Action ◽  
India Ink ◽  
Significant Difference ◽  
Highly Virulent ◽  
Reticulo Endothelial System

1. The minimum amount of diphtheria toxin which killed normal mice of from 24 to 30 gm. in weight upon intravenous injection, was found to be between 75 and 100 times the M.F.D. for the guinea pig. When given intraperitoneally, the fatal dose for mice was as high as 200 M.F.D. 2. There was no significant difference in the lethal action of diphtheria toxin for normal mice and mice in which an elimination of the reticulo-endothelial system had been attempted by means of blocking injections of India ink, or splenectomy, or a combination of both operations. 3. Attempts to infect normal mice and mice treated as described with large doses of a highly virulent diphtheria strain were unsuccessful with both groups of animals.

scholarly journals THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY

1926 ◽  
Vol 43 (5) ◽  
pp. 613-622 ◽  
Author(s):  
C. W. Jungeblut ◽  
J. A. Berlot
Keyword(s):  
Blood Serum ◽  
Guinea Pigs ◽  
Diphtheria Toxin ◽  
Subcutaneous Injection ◽  
Test Dose ◽  
Appreciable Amount ◽  
India Ink ◽  
Diphtheria Antitoxin ◽  
Reticulo Endothelial System

1. Following massive doses of India ink injected intravenously into guinea pigs before a subcutaneous injection of diphtheria toxin-antitoxin mixture, no antitoxin was found in the blood serum for 3 weeks, as indicated by intracutaneous tests, whereas an appreciable amount could be detected in non-blocked, immunized control animals. 2. During the 4th week following immunization, the titer of the serum of blocked animals equaled that of non-blocked controls within the limits of the intracutaneous test dose. 3. The smaller doses of India ink used in these experiments, given before immunization, had no stimulating effect on the production of diphtheria antitoxin but, on the contrary, also inhibited the appearance of this antibody, although to a less extent.

scholarly journals METHOD FOR INTRAVENOUS INJECTION OF GUINEA PIGS

1918 ◽  
Vol 27 (4) ◽  
pp. 459-462 ◽  
Author(s):  
Peyton Rous
Keyword(s):  
Intravenous Injection ◽  
Guinea Pigs
Sign in / Sign up

Export Citation Format

Share Document