violet light
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Author(s):  
Mara Biasin ◽  
Sergio Strizzi ◽  
Andrea Bianco ◽  
Alberto Macchi ◽  
Olga Utyro ◽  
...  
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2021 ◽  
Author(s):  
Hidenaga Kobashi ◽  
Takashi Yano ◽  
Kazuo Tsubota

Abstract Purpose: We evaluated the use of collagenase treatment to generate a rabbit model of keratoconus and the impact of violet light (VL) irradiation on the disease model in six Japanese White rabbits. Methods: After epithelial debridement, the collagenase group was treated with a collagenase type II solution for 30 min; the control group was treated with a solution without collagenase. Three rabbits also underwent VL irradiation (375 nm, irradiance 310 μW/cm2) for 3 hours daily for 7 days after topical collagenase application. Slit-lamp microscopy results, steep keratometry (Ks), corneal astigmatism, central corneal thickness, and axial length were examined before and after the procedure. The corneas were obtained on day 7 for biomechanical evaluation. Results: A significant increase in Ks and corneal astigmatism was observed in the collagenase and VL irradiation groups compared with the control group at day 7. No significant difference was found in the change in corneal thickness between the groups. The elastic modulus at 10% strain, but not at 3% and 5% strain, was significantly lower in the collagenase group than in the control group. There was no significant difference in the elastic modulus at each level of strain between the collagenase and VL irradiation groups. The average axial length at day 7 was significantly longer in the collagenase group than in the control group. Collagenase treatment induced a keratoconic model by steepening the keratometric and astigmatic values. There was no significant difference in the observed elastic behaviour of normal and ectatic corneas under physiologically relevant stress levels. Conclusion: VL irradiation did not cause regression of corneal steepening in collagenase-induced model during short-term observation.


2021 ◽  
Vol 10 (5) ◽  
pp. 12
Author(s):  
Hidenaga Kobashi ◽  
Shunji Yunoki ◽  
Naoko Kato ◽  
Jun Shimazaki ◽  
Takeshi Ide ◽  
...  

2021 ◽  
Vol 10 (22) ◽  
pp. 5462
Author(s):  
Kiwako Mori ◽  
Hidemasa Torii ◽  
Yutaka Hara ◽  
Michiko Hara ◽  
Erisa Yotsukura ◽  
...  

The fact that outdoor light environment is an important suppressive factor against myopia led us to invent violet light-transmitting eyeglasses (VL glasses) which can transmit violet light (VL), 360–400 nm in wavelength, for the suppression of myopia, and can meanwhile block harmful ultraviolet waves from sunlight. The current study is a double-blinded randomized clinical trial to investigate the myopia-suppressive effect of VL glasses compared to conventional eyeglasses (placebo glasses) that do not transmit VL. The subjects were children aged from 6 to 12 years old, the population in which myopia progression is generally accelerated, and the myopia suppressive effect was followed up for two years in a city in Japan. Periodical ophthalmic examinations, interviews, and measurements of reflection and axial length under mydriasis were performed at the initial visit (the baseline) and at 1, 6, 12, 18, and 24 months. The mean change in axial length in the VL glasses group was significantly smaller than in the placebo glasses group when time for near-work was less than 180 min and when the subjects were limited to those who had never used eyeglasses before this trial (p < 0.01); however, this change was not significant without subgrouping. The suppressive rate for axial elongation in the VL glasses group was 21.4% for two years.


2021 ◽  
pp. 4245-4254
Author(s):  
Liang Wang ◽  
Qingxun Guo ◽  
Jiashun Duan ◽  
Weiwei Xie ◽  
Guoqi Ji ◽  
...  

Antibiotics ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1348
Author(s):  
Dan Wang ◽  
Takayuki Nambu ◽  
Hiroaki Tanimoto ◽  
Naohiro Iwata ◽  
Kazushi Yoshikawa ◽  
...  

Oral microbiome dysbiosis has important links to human health and disease. Although photodynamic therapy influences microbiome diversity, the specific effect of violet light irradiation remains largely unknown. In this study, we analyzed the effect of violet light-emitting diode (LED) irradiation on interdental plaque microbiota. Interdental plaque was collected from 12 human subjects, exposed to violet LED irradiation, and cultured in a specialized growth medium. Next-generation sequencing of the 16S ribosomal RNA genes revealed that α-diversity decreased, whereas β-diversity exhibited a continuous change with violet LED irradiation doses. In addition, we identified several operational taxonomic units that exhibited significant shifts during violet LED irradiation. Specifically, violet LED irradiation led to a significant reduction in the relative abundance of Fusobacterium species, but a significant increase in several species of oral bacteria, such as Veillonella and Campylobacter. Our study provides an overview of oral plaque microbiota changes under violet LED irradiation, and highlights the potential of this method for adjusting the balance of the oral microbiome without inducing antibiotic resistance.


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