scholarly journals Sarcomere length in the beating heart: Synchronicity is optional

2022 ◽  
Vol 154 (2) ◽  
Author(s):  
Michiel Helmes ◽  
Bradley M. Palmer

Helmes and Palmer review research by Kobirumaki-Shimozawa et al.

Author(s):  
G.E. Adomian ◽  
L. Chuck ◽  
W.W. Pannley

Sonnenblick, et al, have shown that sarcomeres change length as a function of cardiac muscle length along the ascending portion of the length-tension curve. This allows the contractile force to be expressed as a direct function of sarcomere length. Below L max, muscle length is directly related to sarcomere length at lengths greater than 85% of optimum. However, beyond the apex of the tension-length curve, i.e. L max, a disparity occurs between cardiac muscle length and sarcomere length. To account for this disproportionate increase in muscle length as sarcomere length remains relatively stable, the concept of fiber slippage was suggested as a plausible explanation. These observations have subsequently been extended to the intact ventricle.


2013 ◽  
Vol 61 (S 01) ◽  
Author(s):  
A Rüffer ◽  
S Kellermann ◽  
C Janssen ◽  
F Münch ◽  
M Demuth ◽  
...  

2005 ◽  
Vol 53 (S 3) ◽  
Author(s):  
J Easo ◽  
M Horst ◽  
P Hoelzl ◽  
E Natour ◽  
O Dapunt

2004 ◽  
Vol 7 (6) ◽  
pp. E639-E643 ◽  
Author(s):  
Cameron N. Riviere ◽  
Nicholas A. Patronik ◽  
Marco A. Zenati
Keyword(s):  

2005 ◽  
Vol 7 (2) ◽  
pp. 88 ◽  
Author(s):  
James R. Edgerton ◽  
Morley A. Herbert ◽  
Katherine K. Jones ◽  
Syma L. Prince ◽  
Tea Acuff ◽  
...  

2010 ◽  
Vol 13 (1) ◽  
pp. 60 ◽  
Author(s):  
Cenk Eray Yildiz ◽  
Murat Sayin ◽  
Halit Yerebakan ◽  
Suha Kucukaksu

The importance of minimally invasive cardiac operations, performed off-pump, without the support of cardiopulmonary bypass (CPB), is continuously increasing. Complete revascularization of obstructed coronary arteries is needed to obtain a better long-term outcome. Insertion into the left ventricle of an efficient microaxial pump can be useful when targeting an important coronary artery located at posterior wall of the heart in a patient with hemodynamic deficiency. The use of such a device can enable surgeons to avoid conversion from a preplanned off-pump strategy to traditional on-pump coronary bypass surgery. The Impella Microaxial Ventricular Assist Device (VAD) (Abiomed, Aachen, Germany) is a miniature pump with a 7-mm catheter and a flow rate of approximately 2.5-5 L/min. This device can enable cardiovascular surgery to be performed without damaging the left ventricle and causing serious aortic deficiency. Therefore, in patients with serious comorbidity, complete revascularization may be performed off pump, with the heart beating, because of the hemodynamic stability provided with the support of the microaxial intracardiac pump. If required, this pump can also support the heart during the early postoperative period. We report the first assisted beating-heart coronary artery bypass graft surgery performed with the Impella Microaxial VAD in our country. The surgery was performed on 2 patients considered high risk on the basis of EUROSCORE testing.


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