scholarly journals Whole‐Transcriptome Analysis ofPlasmodium falciparumField Isolates: Identification of New Pathogenicity Factors

2007 ◽  
Vol 196 (11) ◽  
pp. 1603-1612 ◽  
Author(s):  
Anthony Siau ◽  
Fousseyni S. Touré ◽  
Odile Ouwe‐Missi‐Oukem‐Boyer ◽  
Liliane Cicéron ◽  
Nassira Mahmoudi ◽  
...  
Keyword(s):  
Transcriptome Analysis ◽  
Pathogenicity Factors ◽  
Whole Transcriptome Analysis ◽  
Whole Transcriptome

scholarly journals 184 Whole-transcriptome analysis by RNA-Seq for genetic diagnosis of Mendelian skin disorders in the context of consanguinity

2021 ◽  
Vol 141 (5) ◽  
pp. S32
Author(s):  
L. Youssefian ◽  
A. Saeidian ◽  
P. Fortina ◽  
A. South ◽  
J. Uitto ◽  
...  
Keyword(s):  
Transcriptome Analysis ◽  
Genetic Diagnosis ◽  
Rna Seq ◽  
Skin Disorders ◽  
Whole Transcriptome Analysis ◽  
Whole Transcriptome

scholarly journals Alterations of Immune and Keratinization Gene Expression in Papulopustular Rosacea by Whole Transcriptome Analysis

2020 ◽  
Vol 140 (5) ◽  
pp. 1100-1103.e4 ◽  
Author(s):  
Yi-Hsien Shih ◽  
Jin Xu ◽  
Anusha Kumar ◽  
Rui Li ◽  
Anne Lynn S. Chang
Keyword(s):  
Gene Expression ◽  
Transcriptome Analysis ◽  
Whole Transcriptome Analysis ◽  
Whole Transcriptome

Whole Transcriptome Analysis: Implication to Estrous Cycle Regulation

2021 ◽  
Author(s):  
Xiaopeng An ◽  
Yue Zhang ◽  
Fu Li ◽  
Zhanhang Wang ◽  
Shaohua Yang ◽  
...  
Keyword(s):  
Estrous Cycle ◽  
Transcriptome Analysis ◽  
Circular Rna ◽  
Differentially Expressed ◽  
Non Coding Rna ◽  
Non Coding Rnas ◽  
Whole Transcriptome Analysis ◽  
Cycle Regulation ◽  
Whole Transcriptome ◽  
Goat Ovary

Abstract BackgroundEstrous cycle is one of female characteristics after sexual maturity, including estrus (ES) and diestrus (DS) stages. Estrous cycle is important in female physiology and its disorder may lead to diseases. In the latest years, effects of non-coding RNAs and mRNA on estrous cycle start to arouse much concern, however, a whole transcriptome analysis among non-coding RNAs and mRNA has not been reported.ResultsHere we report a whole transcriptome analysis of goat ovary in estrus and diestrus periods. Estrus synchronization was conducted to induce the estrus phase and on day 32, the goats naturally shifted into diestrus stage. The ovary RNA of estrus and diestrus stages was respectively collected to perform RNA-sequencing. Then the circular RNA; microRNA; long non-coding RNA; mRNA databases of goat ovary were acquired, and the differentially expressions between estrus and diestrus stages were screened to construct circRNA-miRNA-mRNA/lncRNA and lncRNA-miRNA/mRNA networks, thus providing potential pathways that involved in the regulation of estrous cycle. Differentially expressed mRNAs, such as MMP9, TIMP1, 3BHSD and PTGIS, and differentially expressed microRNAs, such as miR-21-3p，miR-202-3p and miR-223-3p, which play key roles in estrous cycle regulation were extracted from the network.ConclusionsOur data provided the miRNA, circRNA, lncRNA and mRNA databases of goat ovary and each differentially expressed profile between ES and DS. Networks among differentially expressed miRNAs, circRNAs, lncRNAs and mRNAs were constructed to provide valuable resources for the study of estrous cycle and related diseases.

scholarly journals Regional heterogeneity in rat Peyer’s patches through whole transcriptome analysis

2020 ◽  
pp. 153537022097301
Author(s):  
Charles L Phillips ◽  
Bradley A Welch ◽  
Michael R Garrett ◽  
Bernadette E Grayson
Keyword(s):  
Gene Expression ◽  
Small Intestine ◽  
Transcriptome Analysis ◽  
Expression Patterns ◽  
Gene Expression Pattern ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Junction Protein ◽  
Whole Transcriptome Analysis ◽  
Whole Transcriptome

Peyer’s patches are gut-associated lymphoid tissue located throughout the intestinal wall. Peyer’s patches consist of highly organized ovoid-shaped follicles, classified as non-encapsulated lymphatic tissues, populated with B cells, T cells, macrophages, and dendritic cells and function as an organism’s intestinal surveillance. Limited work compares the gene profiles of Peyer’s patches derived from different intestinal regions. In the current study, we first performed whole transcriptome analysis using RNAseq to compare duodenal and ileal Peyer’s patches obtained from the small intestine of Long Evans rats. Of the 12,300 genes that were highly expressed, 18.5% were significantly different between the duodenum and ileum. Using samples obtained from additional subjects ( n = 10), we validated the novel gene expression patterns in Peyer’s patches obtained from the three regions of the small intestine. Rats had a significantly reduced number of Peyer’s patches in the duodenum in comparison to either the jejunum or ileum. Regional differences in structural, metabolic, and immune-related genes were validated. Genes such as alcohol dehydrogenase 1, gap junction protein beta 2, and serine peptidase inhibitor clade b, member 1a were significantly reduced in the ileum in comparison to other regions. On the other hand, genes such as complement C3d receptor type, lymphocyte cytosolic protein 1, and lysozyme C2 precursor were significantly lower in the duodenum. In summary, the gene expression pattern of Peyer’s patches is influenced by intestinal location and may contribute to its role in that segment.

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