Recombinant gp350 Vaccine for Infectious Mononucleosis: A Phase 2, Randomized, Double‐Blind, Placebo‐Controlled Trial to Evaluate the Safety, Immunogenicity, and Efficacy of an Epstein‐Barr Virus Vaccine in Healthy Young Adults

Abstract Cold agglutinins (CA) were evaluated prospectively in patients with various mononucleosis syndromes and in a large control group. Cold agglutinins with anti-i specificity were seen mainly in heterophil- positive or -negative Epstein-Barr virus (EBV)-induced infectious mononucleosis (31.8% of cases). Unclassified CA with equal reactivity against cord and adult erythrocytes were seen in 56 of 150 (37.3%) cases of heterophil-antibody-positive infectious mononucleosis (IM), in 1 of 7 (14.3%) cases of heterophil-negative EBV-induced IM, and in 12 of 31 (38.7%) cases of the heterophil-negative mononucleosis-like syndrome due to cytomegalovirus or other unspecified agents. One patient with heterophil-positive IM had a persistent, partially papain sensitive CA with anti-Pr-like activity. Anti-i CA were seen in less than 1.0% of healthy young adults (500) or patients without mononucleosis (500) submitted for heterophil studies. Unclassified CA were noted in 3.2% of the latter 1000 samples.

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Epstein‐Barr Virus Vaccine for the Prevention of Infectious Mononucleosis—and What Else?

The Journal of Infectious Diseases ◽

10.1086/523815 ◽

2007 ◽

Vol 196 (12) ◽

pp. 1724-1726 ◽

Cited By ~ 14

Author(s):

Henry H. Balfour, Jr.

Keyword(s):

Infectious Mononucleosis ◽

Virus Vaccine ◽

Epstein Barr Virus ◽

Barr Virus ◽

Epstein Barr

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Clinical and laboratory presentation of EBV positive infectious mononucleosis in young adults

Epidemiology and Infection ◽

10.1017/s0950268803008550 ◽

2003 ◽

Vol 131 (1) ◽

pp. 683-689 ◽

Cited By ~ 42

Author(s):

I. GROTTO ◽

D. MIMOUNI ◽

M. HUERTA ◽

M. MIMOUNI ◽

D. COHEN ◽

...

Keyword(s):

Young Adults ◽

Infectious Mononucleosis ◽

Epstein Barr Virus ◽

Liver Enzymes ◽

Barr Virus ◽

Ebv Infection ◽

Elevated Liver Enzymes ◽

Disease Pattern ◽

Epstein Barr ◽

Low Sensitivity

Clinical descriptions of Epstein–Barr virus (EBV) positive infectious mononucleosis (IM) are rare and their results are inconsistent. Over a 4-year period, we prospectively studied 590 young adults with clinically suspected IM, all of whom were tested for the presence of EBV IgM antibodies. We investigated the demographical, clinical and laboratory features of subjects with positive EBV IgM serology and heterophile antibodies. Contrary to previous studies, we found a seasonal disease pattern with a peak incidence during summer months, and a lower-than-expected prevalence of lymphadenopathy (88·9%), leucocytosis (46·2%), atypical lymphocytosis (89·2%) and elevated liver enzymes (57·9%). The prevalence of hyperbilirubinemia was relatively high (14·9%). The classic triad of fever, sore throat and lymph-adenopathy had relatively low sensitivity (68·2%) and specificity (41·9%) for EBV infection. Our study provides a complete and updated description of the clinical and laboratory presentation of laboratory confirmed IM, which is important for both clinicians and epidemiologists.

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Infectious Mononucleosis Resulting in Acute Necrotizing Mediastinitis: A Case Report and Literature Review

European Journal of Case Reports in Internal Medicine ◽

10.12890/2020_001829 ◽

2020 ◽

Author(s):

Héloïse Van Noten ◽

Samuel Markowicz ◽

Serge Cappeliez ◽

Soraya Cherifi

Keyword(s):

Young Adults ◽

Infectious Mononucleosis ◽

Primary Infection ◽

Epstein Barr Virus ◽

Hemophagocytic Syndrome ◽

English Literature ◽

Barr Virus ◽

Reactive Hemophagocytic Syndrome ◽

Acute Necrotizing ◽

Epstein Barr

The serological prevalence of Epstein-Barr virus (EBV) among young adults exceeds 90% worldwide. Even though EBV primary infection is usually benign, severe complications can occur in adolescents and young adults and so the disease must be promptly diagnosed. The development of an oropharyngeal abscess leading to a descending necrotizing mediastinitis (DNM) is exceptional and potentially lethal, so early diagnosis with a CT scan, appropriate antibiotics and surgery are essential. The authors present a case where DNM was associated with reactive hemophagocytic syndrome as a result of infectious mononucleosis, as well as a review of similar cases in the English literature.

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Cold agglutinins in infectious mononucleosis and heterophil-antibody- negative mononucleosis-like syndromes

Blood ◽

10.1182/blood.v50.2.195.bloodjournal502195 ◽

1977 ◽

Vol 50 (2) ◽

pp. 195-202 ◽

Cited By ~ 4

Author(s):

CA Horwitz ◽

J Moulds ◽

W Henle ◽

G Henle ◽

H Polesky ◽

...

Keyword(s):

Young Adults ◽

Infectious Mononucleosis ◽

Epstein Barr Virus ◽

Control Group ◽

Cold Agglutinins ◽

Barr Virus ◽

Epstein Barr

Cold agglutinins (CA) were evaluated prospectively in patients with various mononucleosis syndromes and in a large control group. Cold agglutinins with anti-i specificity were seen mainly in heterophil- positive or -negative Epstein-Barr virus (EBV)-induced infectious mononucleosis (31.8% of cases). Unclassified CA with equal reactivity against cord and adult erythrocytes were seen in 56 of 150 (37.3%) cases of heterophil-antibody-positive infectious mononucleosis (IM), in 1 of 7 (14.3%) cases of heterophil-negative EBV-induced IM, and in 12 of 31 (38.7%) cases of the heterophil-negative mononucleosis-like syndrome due to cytomegalovirus or other unspecified agents. One patient with heterophil-positive IM had a persistent, partially papain sensitive CA with anti-Pr-like activity. Anti-i CA were seen in less than 1.0% of healthy young adults (500) or patients without mononucleosis (500) submitted for heterophil studies. Unclassified CA were noted in 3.2% of the latter 1000 samples.

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