scholarly journals Cold agglutinins in infectious mononucleosis and heterophil-antibody- negative mononucleosis-like syndromes

Blood ◽  
1977 ◽  
Vol 50 (2) ◽  
pp. 195-202 ◽  
Author(s):  
CA Horwitz ◽  
J Moulds ◽  
W Henle ◽  
G Henle ◽  
H Polesky ◽  
...  
Keyword(s):  
Young Adults ◽  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Control Group ◽  
Cold Agglutinins ◽  
Barr Virus ◽  
Epstein Barr

Abstract Cold agglutinins (CA) were evaluated prospectively in patients with various mononucleosis syndromes and in a large control group. Cold agglutinins with anti-i specificity were seen mainly in heterophil- positive or -negative Epstein-Barr virus (EBV)-induced infectious mononucleosis (31.8% of cases). Unclassified CA with equal reactivity against cord and adult erythrocytes were seen in 56 of 150 (37.3%) cases of heterophil-antibody-positive infectious mononucleosis (IM), in 1 of 7 (14.3%) cases of heterophil-negative EBV-induced IM, and in 12 of 31 (38.7%) cases of the heterophil-negative mononucleosis-like syndrome due to cytomegalovirus or other unspecified agents. One patient with heterophil-positive IM had a persistent, partially papain sensitive CA with anti-Pr-like activity. Anti-i CA were seen in less than 1.0% of healthy young adults (500) or patients without mononucleosis (500) submitted for heterophil studies. Unclassified CA were noted in 3.2% of the latter 1000 samples.

scholarly journals Cold agglutinins in infectious mononucleosis and heterophil-antibody- negative mononucleosis-like syndromes

Blood ◽  
1977 ◽  
Vol 50 (2) ◽  
pp. 195-202 ◽  
Author(s):  
CA Horwitz ◽  
J Moulds ◽  
W Henle ◽  
G Henle ◽  
H Polesky ◽  
...  
Keyword(s):  
Young Adults ◽  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Control Group ◽  
Cold Agglutinins ◽  
Barr Virus ◽  
Epstein Barr

Cold agglutinins (CA) were evaluated prospectively in patients with various mononucleosis syndromes and in a large control group. Cold agglutinins with anti-i specificity were seen mainly in heterophil- positive or -negative Epstein-Barr virus (EBV)-induced infectious mononucleosis (31.8% of cases). Unclassified CA with equal reactivity against cord and adult erythrocytes were seen in 56 of 150 (37.3%) cases of heterophil-antibody-positive infectious mononucleosis (IM), in 1 of 7 (14.3%) cases of heterophil-negative EBV-induced IM, and in 12 of 31 (38.7%) cases of the heterophil-negative mononucleosis-like syndrome due to cytomegalovirus or other unspecified agents. One patient with heterophil-positive IM had a persistent, partially papain sensitive CA with anti-Pr-like activity. Anti-i CA were seen in less than 1.0% of healthy young adults (500) or patients without mononucleosis (500) submitted for heterophil studies. Unclassified CA were noted in 3.2% of the latter 1000 samples.

scholarly journals THE VALUE OF THE IMMUNE RESPONSE IN PATIENTS WITH EBV INFECTIOUS MONONUCLEOSIS IN PREDICTING THE COURSE AND EFFICACY OF ANTIVIRAL AND IMMUNO IMMUNOCORRECTING THERAPY

2013 ◽  
Vol 18 (1) ◽  
pp. 7-14
Author(s):  
T. A. Svintsova ◽  
D. M. Sobchak ◽  
O. V. Korochkina ◽  
G. A Kravchenko ◽  
V. V Novikov
Keyword(s):  
Immune Response ◽  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Mononuclear Cells ◽  
Polyclonal Antibodies ◽  
Severity Of Illness ◽  
Control Group ◽  
Differentiation Antigens ◽  
Barr Virus ◽  
Epstein Barr

The indices of immune response were studied in 68 patients with infectious mononucleosis caused by the Epstein-Barr virus (35 males, 33 females) aged 18 to 30 years. Materials and methods. The content of soluble forms of differentiation antigens (sCD95, sCD18, sCD50, sHLAI, sCD54) has been studied with enzyme immunoassay using monoclonal antibodies Mab IC0-20 and polyclonal antibodies to the antigens of the mononuclear cells of the peripheral blood. The control group included 60 healthy volunteers matched for age and sex with the main group. The aim of this study is the assessment of the content of soluble forms of differentiation antigens in patients with infectious mononucleosis caused by Epstein-Barr virus, depending on gender, age, severity of illness, comorbidities, laboratory values, the presence of viral DNA, as well as a demonstration of their value in predicting the course and outcome of the disease and the efficacy of antiviral and immunocorrecting therapy. In patients with negative results of DNA indication of EBV a significant increase in the content of soluble forms of differentiation antigens characterizing the adhesion of leukocytes (sCD18), the activity of T-lymphocytes (sCD50), the recognition of foreign antigens (sHLAI) in the blood in comparison with patients with a positive DNA indication of EBV was determined. Conclusion. According to the results of this performed work the criterion for an adequate immune response in patients with infectious mononucleosis caused by the Epstein-Barr virus was found to be the increase of the content of soluble forms of differentiation antigens (sCD95, sCD18, sCD50 sHLAI, sCD54). In patients with exanthema, tonsillar syndrome, leukocytosis, elevation of transaminases and the presence of antibodies to capsid antigen (a/VCAIgM) the content of soluble forms of differentiation antigens (sCD95, sCD18, sCD50 sHLAI, sCD54), was higher than in patients without such symptoms. In the treatment with cycloferon in patients with cyclic course of EBV infectious mononucleosis the content of sHLAI and sCD54 at 2nd-4th weeks of treatment increased by 1.5-2 times compared with the corresponding values before treatment. In patients with reactivation of the disease monotonically low indices of all studied soluble forms of differentiation antigens persisted over the 4 weeks during patients following up. In patients with infectious mononucleosis caused by Epstein-Barr virus, the dynamics of sHLAI and sCD54 after 2-4 weeks of treatment serves as secondary efficacy endpoint of antiviral, immunomodulatory therapy and the formation of the cyclic course of the disease.

scholarly journals Clinical and laboratory presentation of EBV positive infectious mononucleosis in young adults

2003 ◽  
Vol 131 (1) ◽  
pp. 683-689 ◽  
Author(s):  
I. GROTTO ◽  
D. MIMOUNI ◽  
M. HUERTA ◽  
M. MIMOUNI ◽  
D. COHEN ◽  
...  
Keyword(s):  
Young Adults ◽  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Liver Enzymes ◽  
Barr Virus ◽  
Ebv Infection ◽  
Elevated Liver Enzymes ◽  
Disease Pattern ◽  
Epstein Barr ◽  
Low Sensitivity

Clinical descriptions of Epstein–Barr virus (EBV) positive infectious mononucleosis (IM) are rare and their results are inconsistent. Over a 4-year period, we prospectively studied 590 young adults with clinically suspected IM, all of whom were tested for the presence of EBV IgM antibodies. We investigated the demographical, clinical and laboratory features of subjects with positive EBV IgM serology and heterophile antibodies. Contrary to previous studies, we found a seasonal disease pattern with a peak incidence during summer months, and a lower-than-expected prevalence of lymphadenopathy (88·9%), leucocytosis (46·2%), atypical lymphocytosis (89·2%) and elevated liver enzymes (57·9%). The prevalence of hyperbilirubinemia was relatively high (14·9%). The classic triad of fever, sore throat and lymph-adenopathy had relatively low sensitivity (68·2%) and specificity (41·9%) for EBV infection. Our study provides a complete and updated description of the clinical and laboratory presentation of laboratory confirmed IM, which is important for both clinicians and epidemiologists.

scholarly journals Infectious Mononucleosis Resulting in Acute Necrotizing Mediastinitis: A Case Report and Literature Review

2020 ◽  
Author(s):  
Héloïse Van Noten ◽  
Samuel Markowicz ◽  
Serge Cappeliez ◽  
Soraya Cherifi
Keyword(s):  
Young Adults ◽  
Infectious Mononucleosis ◽  
Primary Infection ◽  
Epstein Barr Virus ◽  
Hemophagocytic Syndrome ◽  
English Literature ◽  
Barr Virus ◽  
Reactive Hemophagocytic Syndrome ◽  
Acute Necrotizing ◽  
Epstein Barr

The serological prevalence of Epstein-Barr virus (EBV) among young adults exceeds 90% worldwide. Even though EBV primary infection is usually benign, severe complications can occur in adolescents and young adults and so the disease must be promptly diagnosed. The development of an oropharyngeal abscess leading to a descending necrotizing mediastinitis (DNM) is exceptional and potentially lethal, so early diagnosis with a CT scan, appropriate antibiotics and surgery are essential.  The authors present a case where DNM was associated with reactive hemophagocytic syndrome as a result of infectious mononucleosis, as well as a review of similar cases in the English literature.

Infectious Mononucleosis and Epstein Barr Virus in Childhood

PEDIATRICS ◽  
1974 ◽  
Vol 53 (3) ◽  
pp. 330-335
Author(s):  
Dov Tamir ◽  
Abraham Benderly ◽  
Joseph Levy ◽  
Edna Ben-Porath ◽  
Ami Vonsover
Keyword(s):  
Antibody Titer ◽  
Infectious Mononucleosis ◽  
Strong Correlation ◽  
Epstein Barr Virus ◽  
Blood Smear ◽  
Mononuclear Cells ◽  
Peripheral Blood Smear ◽  
Control Group ◽  
Barr Virus ◽  
Epstein Barr

The Epstein-Barr virus (EBV) antibody titer was examined in 22 children whose atypical mononuclear cells appeared in the peripheral blood smear. Paul-Bunnell and mononucleosis tests were negative in all these children, but antibodies to EBV were demonstrated in 21 of them. Only five children in a control group of 27 had antibodies to EBV. We conclude that the presence of EBV antibodies with a rising titer supports a diagnosis of infectious mononucleosis. It is of particular importance in children under 1 year of age in whom the finding of atypical mononuclear cells in the absence of positive Paul-Bunnell and mononucleosis tests shows a strong correlation with EBV antibody titer. This finding frequently occurs in the absence of typical clinical features of infectious mononucleosis.

scholarly journals Valacyclovir Pharmacokinetics and Exploratory Pharmacodynamics in Young Adults With Epstein-Barr Virus Infectious Mononucleosis

2010 ◽  
Vol 50 (7) ◽  
pp. 734-742 ◽  
Author(s):  
Heather E. Vezina ◽  
Henry H. Balfour ◽  
Dennis R. Weller ◽  
Bruce J. Anderson ◽  
Richard C. Brundage
Keyword(s):  
Young Adults ◽  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr

Diagnosis of infectious mononucleosis caused by Epstein-Barr virus in infants

2010 ◽  
Vol 52 (4) ◽  
pp. 536-540 ◽  
Author(s):  
Sumitaka Dohno ◽  
Akihiko Maeda ◽  
Yoshihito Ishiura ◽  
Tetsuya Sato ◽  
Mikiya Fujieda ◽  
...  
Keyword(s):  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Acute Acalculous Cholecystitis Due to a Primary Epstein Barr Virus Infection in a Pediatric Patient

2021 ◽  
Vol 13 (1) ◽  
pp. 86-90
Author(s):  
Carlos Leganés Villanueva ◽  
Ilaria Goruppi ◽  
Nuria Brun Lozano ◽  
Federica Bianchi ◽  
María Quinteiro González ◽  
...  
Keyword(s):  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Acalculous Cholecystitis ◽  
Acute Acalculous Cholecystitis ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Acute Complications ◽  
Epstein Barr ◽  
Barr Virus Infection ◽  
Human Viruses

Epstein–Barr virus (EBV) is estimated to infect more than 98% of adults worldwide and is one of the most common human viruses. Acute acalculous cholecystitis (AAC) of the gallbladder is an atypical complication of infectious mononucleosis caused by EBV. Conservative management has been described in the context of AAC caused by EBV. A surgical approach must be considered in the case of acute complications such as perforation or gallbladder gangrene. We present the case of a 10-year-old female patient with AAC due to infectious mononucleosis syndrome caused by primary EBV infection.

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