scholarly journals Infectious Mononucleosis Resulting in Acute Necrotizing Mediastinitis: A Case Report and Literature Review

2020 ◽  
Author(s):  
Héloïse Van Noten ◽  
Samuel Markowicz ◽  
Serge Cappeliez ◽  
Soraya Cherifi
Keyword(s):  
Young Adults ◽  
Infectious Mononucleosis ◽  
Primary Infection ◽  
Epstein Barr Virus ◽  
Hemophagocytic Syndrome ◽  
English Literature ◽  
Barr Virus ◽  
Reactive Hemophagocytic Syndrome ◽  
Acute Necrotizing ◽  
Epstein Barr

The serological prevalence of Epstein-Barr virus (EBV) among young adults exceeds 90% worldwide. Even though EBV primary infection is usually benign, severe complications can occur in adolescents and young adults and so the disease must be promptly diagnosed. The development of an oropharyngeal abscess leading to a descending necrotizing mediastinitis (DNM) is exceptional and potentially lethal, so early diagnosis with a CT scan, appropriate antibiotics and surgery are essential.  The authors present a case where DNM was associated with reactive hemophagocytic syndrome as a result of infectious mononucleosis, as well as a review of similar cases in the English literature.

Epstein-Barr Virus Is Not Synonymous With Infectious Mononucleosis

PEDIATRICS ◽  
1978 ◽  
Vol 61 (3) ◽  
pp. 506-506
Author(s):  
Alex J. Steigman
Keyword(s):  
Infectious Mononucleosis ◽  
Primary Infection ◽  
Epstein Barr Virus ◽  
Clinical Syndrome ◽  
Barr Virus ◽  
Clinical Responses ◽  
Epstein Barr ◽  
Uncertain Etiology

Infectious mononucleosis (IM) is a defined clinical syndrome, until recently regarded as of uncertain etiology affecting only a limited number of persons. The etiology of IM can now be ascribed correctly to primary infection with Epstein-Barr virus (EBV), a member of the herpesvirus family. It is increasingly evident that primary infection with EBV may also induce a range of clinical responses from no detectable illness1 to a variety of disorders without the clinical or hematologic hallmarks of the IM syndrome.

scholarly journals Cold agglutinins in infectious mononucleosis and heterophil-antibody- negative mononucleosis-like syndromes

Blood ◽  
1977 ◽  
Vol 50 (2) ◽  
pp. 195-202 ◽  
Author(s):  
CA Horwitz ◽  
J Moulds ◽  
W Henle ◽  
G Henle ◽  
H Polesky ◽  
...  
Keyword(s):  
Young Adults ◽  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Control Group ◽  
Cold Agglutinins ◽  
Barr Virus ◽  
Epstein Barr

Abstract Cold agglutinins (CA) were evaluated prospectively in patients with various mononucleosis syndromes and in a large control group. Cold agglutinins with anti-i specificity were seen mainly in heterophil- positive or -negative Epstein-Barr virus (EBV)-induced infectious mononucleosis (31.8% of cases). Unclassified CA with equal reactivity against cord and adult erythrocytes were seen in 56 of 150 (37.3%) cases of heterophil-antibody-positive infectious mononucleosis (IM), in 1 of 7 (14.3%) cases of heterophil-negative EBV-induced IM, and in 12 of 31 (38.7%) cases of the heterophil-negative mononucleosis-like syndrome due to cytomegalovirus or other unspecified agents. One patient with heterophil-positive IM had a persistent, partially papain sensitive CA with anti-Pr-like activity. Anti-i CA were seen in less than 1.0% of healthy young adults (500) or patients without mononucleosis (500) submitted for heterophil studies. Unclassified CA were noted in 3.2% of the latter 1000 samples.

scholarly journals Clinical and laboratory presentation of EBV positive infectious mononucleosis in young adults

2003 ◽  
Vol 131 (1) ◽  
pp. 683-689 ◽  
Author(s):  
I. GROTTO ◽  
D. MIMOUNI ◽  
M. HUERTA ◽  
M. MIMOUNI ◽  
D. COHEN ◽  
...  
Keyword(s):  
Young Adults ◽  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Liver Enzymes ◽  
Barr Virus ◽  
Ebv Infection ◽  
Elevated Liver Enzymes ◽  
Disease Pattern ◽  
Epstein Barr ◽  
Low Sensitivity

Clinical descriptions of Epstein–Barr virus (EBV) positive infectious mononucleosis (IM) are rare and their results are inconsistent. Over a 4-year period, we prospectively studied 590 young adults with clinically suspected IM, all of whom were tested for the presence of EBV IgM antibodies. We investigated the demographical, clinical and laboratory features of subjects with positive EBV IgM serology and heterophile antibodies. Contrary to previous studies, we found a seasonal disease pattern with a peak incidence during summer months, and a lower-than-expected prevalence of lymphadenopathy (88·9%), leucocytosis (46·2%), atypical lymphocytosis (89·2%) and elevated liver enzymes (57·9%). The prevalence of hyperbilirubinemia was relatively high (14·9%). The classic triad of fever, sore throat and lymph-adenopathy had relatively low sensitivity (68·2%) and specificity (41·9%) for EBV infection. Our study provides a complete and updated description of the clinical and laboratory presentation of laboratory confirmed IM, which is important for both clinicians and epidemiologists.

Infectious mononucleosis and Epstein-Barr virus

2004 ◽  
Vol 6 (23) ◽  
pp. 1-16 ◽  
Author(s):  
Eleni-Kyriaki Vetsika ◽  
Margaret Callan
Keyword(s):  
Infectious Mononucleosis ◽  
Primary Infection ◽  
Epstein Barr Virus ◽  
Latent Infection ◽  
Clinical Syndrome ◽  
Primary Immune Response ◽  
Barr Virus ◽  
Glandular Fever ◽  
Ebv Infection ◽  
Epstein Barr

Epstein-Barr virus (EBV) is a γ-herpesvirus that infects over 90% of the human population worldwide. It is usually transmitted between individuals in saliva, and establishes replicative infection within the oropharynx as well as life-long latent infection of B cells. Primary EBV infection generally occurs during early childhood and is asymptomatic. If delayed until adolescence or later, it can be associated with the clinical syndrome of infectious mononucleosis (also known as glandular fever or ‘mono%rsquo;), an illness characterised by fevers, pharyngitis, lymphadenopathy and malaise. EBV infection is also associated with the development of EBV-associated lymphoid or epithelial cell malignancies in a small proportion of individuals. This review focuses on primary EBV infection in individuals suffering from infectious mononucleosis. It discusses the mechanism by which EBV establishes infection within its human host and the primary immune response that it elicits. It describes the spectrum of clinical disease that can accompany primary infection and summarises studies that are leading to the development of a vaccine designed to prevent infectious mononucleosis.

Reactive hemophagocytic syndrome in a patient with polyarteritis nodosa associated with Epstein–Barr virus reactivation

2005 ◽  
Vol 26 (6) ◽  
pp. 573-576 ◽  
Author(s):  
Ikuko Hayakawa ◽  
Fumiaki Shirasaki ◽  
Hiroko Ikeda ◽  
Naoto Oishi ◽  
Minoru Hasegawa ◽  
...  
Keyword(s):  
Polyarteritis Nodosa ◽  
Epstein Barr Virus ◽  
Hemophagocytic Syndrome ◽  
Virus Reactivation ◽  
Barr Virus ◽  
Reactive Hemophagocytic Syndrome ◽  
Epstein Barr ◽  
Epstein Barr Virus Reactivation

Epstein–Barr virus viral load in human immunodeficiency virus-positive patients with reactive hemophagocytic syndrome

2015 ◽  
Vol 47 (6) ◽  
pp. 423-427 ◽  
Author(s):  
Mario Boisseau ◽  
Olivier Lambotte ◽  
Lionel Galicier ◽  
Nathalie Lerolle ◽  
Christophe Marzac ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Viral Load ◽  
Epstein Barr Virus ◽  
Hemophagocytic Syndrome ◽  
Barr Virus ◽  
Reactive Hemophagocytic Syndrome ◽  
Immunodeficiency Virus ◽  
Epstein Barr

scholarly journals Cold agglutinins in infectious mononucleosis and heterophil-antibody- negative mononucleosis-like syndromes

Blood ◽  
1977 ◽  
Vol 50 (2) ◽  
pp. 195-202 ◽  
Author(s):  
CA Horwitz ◽  
J Moulds ◽  
W Henle ◽  
G Henle ◽  
H Polesky ◽  
...  
Keyword(s):  
Young Adults ◽  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Control Group ◽  
Cold Agglutinins ◽  
Barr Virus ◽  
Epstein Barr

Cold agglutinins (CA) were evaluated prospectively in patients with various mononucleosis syndromes and in a large control group. Cold agglutinins with anti-i specificity were seen mainly in heterophil- positive or -negative Epstein-Barr virus (EBV)-induced infectious mononucleosis (31.8% of cases). Unclassified CA with equal reactivity against cord and adult erythrocytes were seen in 56 of 150 (37.3%) cases of heterophil-antibody-positive infectious mononucleosis (IM), in 1 of 7 (14.3%) cases of heterophil-negative EBV-induced IM, and in 12 of 31 (38.7%) cases of the heterophil-negative mononucleosis-like syndrome due to cytomegalovirus or other unspecified agents. One patient with heterophil-positive IM had a persistent, partially papain sensitive CA with anti-Pr-like activity. Anti-i CA were seen in less than 1.0% of healthy young adults (500) or patients without mononucleosis (500) submitted for heterophil studies. Unclassified CA were noted in 3.2% of the latter 1000 samples.

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