Assessing the radiation-induced second cancer risk in proton therapy for pediatric brain tumors: the impact of employing a patient-specific aperture in pencil beam scanning

2015 ◽  
Vol 61 (1) ◽  
pp. 12-22 ◽  
Author(s):  
Changran Geng ◽  
Maryam Moteabbed ◽  
Yunhe Xie ◽  
Jan Schuemann ◽  
Torunn Yock ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Pediatric Brain Tumors ◽  
Patient Specific ◽  
Pencil Beam ◽  
Second Cancer ◽  
Pencil Beam Scanning ◽  
Radiation Induced ◽  
Second Cancer Risk ◽  
The Impact ◽  
Pediatric Brain

scholarly journals 3D calculation of radiation-induced second cancer risk including dose and tissue response heterogeneities

2015 ◽  
Vol 42 (2) ◽  
pp. 866-876 ◽  
Author(s):  
C. Timlin ◽  
D. R. Warren ◽  
B. Rowland ◽  
A. Madkhali ◽  
J. Loken ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Tissue Response ◽  
Second Cancer ◽  
Radiation Induced ◽  
Second Cancer Risk

scholarly journals RONC-19. TWO CASES OF RE-IRRADIATION FOR LATE RECURRENT OR RADIATION-INDUCED TUMOR AFTER RADIATION THERAPY FOR PEDIATRIC BRAIN TUMORS

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii459-iii459
Author(s):  
Takashi Mori ◽  
Shigeru Yamaguchi ◽  
Rikiya Onimaru ◽  
Takayuki Hashimoto ◽  
Hidefumi Aoyama
Keyword(s):  
Radiation Therapy ◽  
Brain Tumors ◽  
Tumor Resection ◽  
Intensity Modulated Radiation Therapy ◽  
Late Recurrence ◽  
Pediatric Brain Tumors ◽  
Suprasellar Region ◽  
Radiation Induced ◽  
Pediatric Brain

Abstract BACKGROUND As the outcome of pediatric brain tumors improves, late recurrence and radiation-induced tumor cases are more likely to occur, and the number of cases requiring re-irradiation is expected to increase. Here we report two cases performed intracranial re-irradiation after radiotherapy for pediatric brain tumors. CASE 1: 21-year-old male. He was diagnosed with craniopharyngioma at eight years old and underwent a tumor resection. At 10 years old, the local recurrence of suprasellar region was treated with 50.4 Gy/28 fr of stereotactic radiotherapy (SRT). After that, other recurrent lesions appeared in the left cerebellopontine angle, and he received surgery three times. The tumor was gross totally resected and re-irradiation with 40 Gy/20 fr of SRT was performed. We have found no recurrence or late effects during the one year follow-up. CASE 2: 15-year-old female. At three years old, she received 18 Gy/10 fr of craniospinal irradiation and 36 Gy/20 fr of boost to the posterior fossa as postoperative irradiation for anaplastic ependymoma and cured. However, a anaplastic meningioma appeared on the left side of the skull base at the age of 15, and 50 Gy/25 fr of postoperative intensity-modulated radiation therapy was performed. Two years later, another meningioma developed in the right cerebellar tent, and 54 Gy/27 fr of SRT was performed. Thirty-three months after re-irradiation, MRI showed a slight increase of the lesion, but no late toxicities are observed. CONCLUSION The follow-up periods are short, however intracranial re-irradiation after radiotherapy for pediatric brain tumors were feasible and effective.

Second cancer risk in childhood cancer survivors treated with intensity-modulated radiation therapy (IMRT)

2014 ◽  
Vol 62 (2) ◽  
pp. 311-316 ◽  
Author(s):  
Dana L. Casey ◽  
Danielle N. Friedman ◽  
Chaya S. Moskowitz ◽  
Patrick D. Hilden ◽  
Charles A. Sklar ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Cancer Risk ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Intensity Modulated Radiation Therapy ◽  
Childhood Cancer Survivors ◽  
Second Cancer ◽  
Intensity Modulated ◽  
Second Cancer Risk
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