Non-normality, reactivity, and intrinsic stochasticity in neural dynamics: a non-equilibrium potential approach

Molecularly imprinted polymer (MIP) receptors have been synthesized, characterized, and applied as new selective receptors in solid-contact ion selective electrodes (ISEs) towards non-dissociated 3,5-dihydroxytoluene (orcinol). Two monomers, namely methacrylic acid (MAA) and acrylamide (AA), were used in the preparation of MIP receptors. Graphene (Gr) was used as the solid contact material between the sensing membrane and the electrical contact substrate. Based on non-equilibrium sensing mechanism, the proposed sensors reveal observably enhanced detection sensitivity towards orcinol with detection limits 1.7 × 10−5 and 3.3 × 10−6 M for sensors based on MIP/MAA and MIP/AA, respectively. The selectivity coefficients measured by the modified separate solution method (MSSM) for the proposed sensors showed good selectivity towards orcinol over most common other phenols and inorganic anions. All measurements were made in the presence of 30 mM phosphate buffer solution (PBS) with a pH of 7.0. Potential stability for the proposed sensors was tested by constant-current chronopotentiometry. No water films were formed between the sensing membrane and the electron conductor substrate. The applicability of MIP/MAA incorporated ISE has been checked by recovery test of orcinol in the presence of soil matrix and by standard addition method.

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Application of analytical electron microscopy to studies of equilibrium and non-equilibrium segregation in materials

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100130705 ◽

1992 ◽

Vol 50 (2) ◽

pp. 1214-1215

Author(s):

Edward A Kenik

Keyword(s):

Electron Microscopy ◽

Analytical Electron Microscopy ◽

Extended Defects ◽

Probe Diameter ◽

Specimen Holder ◽

Analytical Electron ◽

Scanning Transmission ◽

Solute Atoms ◽

Equilibrium Segregation ◽

Non Equilibrium

Segregation of solute atoms to grain boundaries, dislocations, and other extended defects can occur under thermal equilibrium or non-equilibrium conditions, such as quenching, irradiation, or precipitation. Generally, equilibrium segregation is narrow (near monolayer coverage at planar defects), whereas non-equilibrium segregation exhibits profiles of larger spatial extent, associated with diffusion of point defects or solute atoms. Analytical electron microscopy provides tools both to measure the segregation and to characterize the defect at which the segregation occurs. This is especially true of instruments that can achieve fine (<2 nm width), high current probes and as such, provide high spatial resolution analysis and characterization capability. Analysis was performed in a Philips EM400T/FEG operated in the scanning transmission mode with a probe diameter of <2 nm (FWTM). The instrument is equipped with EDAX 9100/70 energy dispersive X-ray spectrometry (EDXS) and Gatan 666 parallel detection electron energy loss spectrometry (PEELS) systems. A double-tilt, liquid-nitrogen-cooled specimen holder was employed for microanalysis in order to minimize contamination under the focussed spot.

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