scholarly journals Transient Bending Vibration of a Piezoelectric Semiconductor Nanofiber under a Harmonic Shear Force

2020 ◽  
Vol 1637 ◽  
pp. 012006
Author(s):  
Yuxing Liang
1993 ◽  
Vol 69 (05) ◽  
pp. 496-502 ◽  
Author(s):  
Yasuo Ikeda ◽  
Makoto Handa ◽  
Tetsuji Kamata ◽  
Koichi Kawano ◽  
Yohko Kawai ◽  
...  

SummaryWe found that the binding of multimeric vWF to GP Ib under a shear force of 108 dynes/cm2 resulted in the transmembrane flux of Ca2+ ions with a two-to three-fold increase in their intracellular concentration ([Ca2+]i). The blockage of this event, obtained by inhibiting the vWF-GP Ib interaction, suppressed aggregation. In contrast, the blockage of vWF binding to GP IIb-IIIa, as well as the prevention of activation caused by increased intracellular cAMP levels, inhibited aggregation but had no significant effect on [Ca2+]i increase. A monomeric recombinant fragment of vWF containing the GP Ib-binding domain of the molecule (residues 445-733) prevented all effects mediated by multimeric vWF but, by itself, failed to support the increase in [Ca2+]i and aggregation. These results suggest that the binding of multimeric vWF to GP Ib initiates platelets aggregation induced by high shear stress by mediating a transmembrane flux of Ca2+ ions, perhaps through a receptor-dependent calcium channel. The increase in [Ca2+]i may act as an intracellular message and cause the activation of GP IIb-IIIa; the latter receptor then binds vWF and mediates irreversible aggregation.


1990 ◽  
Vol 18 (1) ◽  
pp. 13-65 ◽  
Author(s):  
W. W. Klingbeil ◽  
H. W. H. Witt

Abstract A three-component model for a belted radial tire, previously developed by the authors for free rolling without slip, is generalized to include longitudinal forces and deformations associated with driving and braking. Surface tractions at the tire-road interface are governed by a Coulomb friction law in which the coefficient of friction is assumed to be constant. After a brief review of the model, the mechanism of interfacial shear force generation is delineated and explored under traction with perfect adhesion. Addition of the friction law then leads to the inception of slide zones, which propagate through the footprint with increasing severity of maneuvers. Different behavior patterns under driving and braking are emphasized, with comparisons being given of sliding displacements, sliding velocities, and frictional work at the tire-road interface. As a further application of the model, the effect of friction coefficient and of test variables such as load, deflection, and inflation pressure on braking stiffness are computed and compared to analogous predictions on the braking spring rate.


2020 ◽  
Author(s):  
Haomin Wang ◽  
Joseph M. González-Fialkowski ◽  
Wenqian Li ◽  
Yan Yu ◽  
Xiaoji Xu

Atomic force microscopy-infrared microscopy (AFM-IR) provides a route to bypass Abbe’s diffraction limit through photothermal detections of infrared absorption. With the combination of total internal reflection, AFM-IR can operate in the aqueous phase. However, AFM-IR in contact mode suffers from surface damage from the lateral shear force between the tip and sample, and can only achieve 20~25-nm spatial resolution. Here, we develop the liquid-phase peak force infrared (LiPFIR) microscopy that avoids the detrimental shear force and delivers an 8-nm spatial resolution. The non-destructiveness of the LiPFIR microscopy enables <i>in situ</i> chemical measurement of heterogeneous materials and investigations on a range of chemical and physical transformations, including polymer surface reorganization, hydrogen-deuterium isotope exchange, and ethanol-induced denaturation of proteins. We also perform LiPFIR imaging of the budding site of yeast cell wall in the fluid as a demonstration of biological applications. LiPFIR unleashes the potential of in liquid AFM-IR for chemical nanoscopy.


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