scholarly journals Docking Interaction of Chromium(III) Picolinate and Chromate Ion Compounds with Protein Tyrosine Phosphatase as Insulin Receptors

2021 ◽  
Vol 1751 ◽  
pp. 012102
Author(s):  
Y Ambarwati ◽  
M A Martoprawiro ◽  
I Mulyani ◽  
Ismunandar ◽  
D Onggo
2001 ◽  
Vol 173 (1-2) ◽  
pp. 109-120 ◽  
Author(s):  
Xin-Yuan Wang ◽  
Katrin Bergdahl ◽  
Anna Heijbel ◽  
Charlotta Liljebris ◽  
John E. Bleasdale

2019 ◽  
Vol 1338 ◽  
pp. 012009
Author(s):  
Y Ambarwati ◽  
M A Martoprawiro ◽  
I Mulyani ◽  
Ismunandar ◽  
D Onggo

2017 ◽  
Vol 3 (2) ◽  
Author(s):  
Yuli - Ambarwati ◽  
MA Martoprawiro ◽  
I Mulyani ◽  
Ismunandar Ismunandar ◽  
D Onggo

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1742-P
Author(s):  
STEPHANIE M. STANFORD ◽  
MICHAEL A. DIAZ ◽  
JIWEN J. ZOU ◽  
ROBERT J. ARDECKY ◽  
ANTHONY PINKERTON ◽  
...  

2018 ◽  
Vol 17 (3) ◽  
pp. 134-139
Author(s):  
R.M. Perez-Gutierrez

Methanol extract from Lippia graveolens (Mexican oregano) was studied in order to identify inhibitory bioactives for protein tyrosine phosphatase 1B (PTP1B). Known flavone as lutein (1), and another flavone glycoside such as lutein-7-o-glucoside (2), 6-hydroxy-lutein-7-ohexoside (3) and lutein-7-o-ramnoide (4) were isolated from methanol extract of aerial parts of the Lippia graveolens. All isolates were identified based on extensive spectroscopic data analysis, including UV, IR, NMR, MS and compared with spectroscopic data previously reported. These flavones were evaluated for PTP1B inhibitory activity. Among them, compounds 1 and 3 displayed potential inhibitory activity against PTP1B with IC50 values of 7.01 ± 1.25 μg/ml and 18.4 μg/ml, respectively. In addition, compound 2 and 4 showed moderate inhibitory activity with an IC50 value of 23.8 ± 6.21 and 67.8 ± 5.80 μg/ml respectively. Among the four compounds, luteolin was found to be the most potent PTP1B inhibitor compared to the positive control ursolic acid, with an IC50 value of 8.12 ± 1.06 μg/ml. These results indicate that flavonoids constituents contained in Lippia graveolens can be considered as a natural source for the treatment of type 2 diabetes.


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