A Geant4 tool for edge-illumination X-ray phase-contrast imaging

2022 ◽  
Vol 17 (01) ◽  
pp. C01043
Author(s):  
L. Brombal ◽  
L. Rigon ◽  
F. Arfelli ◽  
R.H. Menk ◽  
F. Brun

Abstract The PEPI project is developing a new experimental facility integrating a chromatic photon-counting detector within an edge-illumination (EI) phase-contrast setup. In this context, a novel Geant4-based simulation tool has been introduced with the aim of defining the optimal design of the experimental setup. The code includes a custom X-ray refraction process and allows simulating the whole EI system, comprising a polychromatic and extended source, absorbing masks, substrates, their movement during acquisition, and X-ray detection. In this paper, a realistic spectral detector model is introduced and its energy response validated against experimental data acquired with synchrotron radiation at energies between 26 and 50 keV. Moreover, refraction and transmission images of a plastic phantom are reconstructed from simulation data and successfully compared with theoretical predictions. Finally, an optimization study aiming at finding the effect of the X-ray focal spot size (i.e. spatial coherence) on image quality is presented; the results suggest that, in the considered configuration, the system can tolerate source sizes up to 30 μm, while, for a fixed exposure time, the best signal-to-noise ratio in refraction images is found for source sizes in the order of 10 to 15 μm.

2016 ◽  
Author(s):  
S. Sano ◽  
K. Tanabe ◽  
T. Yoshimuta ◽  
K. Kimura ◽  
T. Shirai ◽  
...  

2021 ◽  
Vol 28 (2) ◽  
pp. 602-608
Author(s):  
Jae-Hee Jeong ◽  
Cheolsoo Eo ◽  
Hyo-Yun Kim ◽  
Jin-Hong Kim ◽  
Chae-Soon Lee ◽  
...  

BL-5C is an in-vacuum undulator beamline dedicated to macromolecular crystallography (MX) at the 3 GeV Pohang Light Source II in Korea. The beamline delivers X-ray beams with a focal spot size of 200 µm × 40 µm (FWHM, H × V) over the energy range 6.5–16.5 keV. The measured flux is 7 × 1011 photons s−1 at 12.659 keV through an aperture size of 50 µm. The experimental station is newly equipped with the photon-counting detector EIGER 9M, the multi-axis micro-diffractometer MD2, and a robotic sample changer with a high-capacity dewar. These instruments enable the operation of this beamline as an automated MX beamline specialized in X-ray fragment screening. This beamline can collect more than 400 data sets a day without human intervention, and a difference map can be automatically calculated by using the data processing pipeline for ligand or fragment identification.


Author(s):  
P. C. Diemoz ◽  
M. Endrizzi ◽  
A. Bravin ◽  
I. K. Robinson ◽  
A. Olivo

Recently, we developed a theoretical model that can predict the signal-to-noise ratio for edge-like features in phase-contrast images. This model was then applied for the estimation of the sensitivity of three different X-ray phase-contrast techniques: propagation-based imaging, analyser-based imaging and grating interferometry. We show here how the same formalism can be used also in the case of the edge illumination (EI) technique, providing results that are consistent with those of a recently developed method for the estimation of noise in the retrieved refraction image. The new model is then applied to calculate, in the case of a given synchrotron radiation set-up, the optimum positions of the pre-sample aperture and detector edge to maximize the sensitivity. Finally, an example of the extremely high angular resolution achievable with the EI technique is presented.


2013 ◽  
Vol 21 (22) ◽  
pp. 25677 ◽  
Author(s):  
Georg Pelzer ◽  
Thomas Weber ◽  
Gisela Anton ◽  
Rafael Ballabriga ◽  
Florian Bayer ◽  
...  

2011 ◽  
Vol 40 (4) ◽  
pp. 627-635 ◽  
Author(s):  
夏天 XIA Tian ◽  
张学龙 ZHANG Xue-long ◽  
马军山 MA Jun-shan ◽  
程敬海 CHENG Jing-hai ◽  
黄勇 HUANG Yong

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