Relationship between total serum immunoglobulin E levels, fractional exhaled breath nitric oxide levels and absolute blood eosinophil counts in atopic and non-atopic asthma: a controlled comparative study

2018 ◽  
Vol 12 (2) ◽  
pp. 026009 ◽  
Author(s):  
S K Shrestha ◽  
Arne Drews ◽  
Lucky Sharma ◽  
Subash Pant ◽  
Sanjeev Shrestha ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Comparative Study ◽  
Immunoglobulin E ◽  
Atopic Asthma ◽  
Serum Immunoglobulin ◽  
Total Serum ◽  
Blood Eosinophil ◽  
Exhaled Breath ◽  
Eosinophil Counts

scholarly journals Frequency of Raised Total Serum Ig E, Sputum Eosinophilia and Blood Eosinophil Count in Patients with Severe Persistent Asthma

2021 ◽  
Vol 35 (1) ◽  
Author(s):  
Shanawer Qaiser
Keyword(s):  
Eosinophil Count ◽  
Inflammatory Markers ◽  
Immunoglobulin E ◽  
Persistent Asthma ◽  
Serum Immunoglobulin ◽  
Total Serum ◽  
Blood Eosinophil ◽  
Blood Eosinophil Count ◽  
Sputum Eosinophilia ◽  
Severe Persistent Asthma

Introduction: Asthma is a chronic inflammatory airway disorder that has several inflammatory phenotypes. Serum immunoglobulin E (IgE) and eosinophils are airway inflammation markers in asthmatic patients. In this research, we assessed the asthma severity with various inflammatory markers. Aims & Objectives: To find the frequency of raised total serum immunoglobulin E, sputum eosinophilia, and absolute blood eosinophil count in patients with severe persistent asthma. Place and duration of study: This study was conducted in Department of Pulmonology, Shaikh Zayed FPGMI, Lahore from 1st October 2018 to 1st April 2019. Material & Methods: A Cross-sectional study in which total of 125 patients were enrolled after fulfilling the inclusion criteria. Blood samples were taken with aseptic measures for total serum immunoglobulin E and absolute blood eosinophils count. Sputum was collected in the sterile jar and dispensed properly to the histopathology lab. Results: Of 125 patients, 44.8% were males, and 55.2% were females. The mean patient's age was 49.37 years, and the mean duration of symptoms was 25.49 years. Raised serum immunoglobulin E levels were seen in 74.4% patients, sputum eosinophilia was seen in 25.6% patients, and increased peripheral eosinophil count was seen in 55.2%. Age was significantly associated with sputum eosinophilia; however, no such association was seen between the other effect modifiers and inflammatory markers. Conclusion: Inflammatory markers immunoglobulin E, sputum and blood eosinophil levels were significantly raised in asthma patients. These can be used in the detection of asthma as their detection is easy, simple, and non-invasive, and they are directly linked to the inflammation.

scholarly journals Epigenome-wide association study of total serum immunoglobulin E in children: a life course approach

2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Cheng Peng ◽  
Andres Cardenas ◽  
Sheryl L. Rifas-Shiman ◽  
Marie-France Hivert ◽  
Diane R. Gold ◽  
...  
Keyword(s):  
Life Course ◽  
Association Study ◽  
Immunoglobulin E ◽  
Serum Immunoglobulin ◽  
Total Serum ◽  
Life Course Approach

Total serum immunoglobulin E as a marker for missed antigens on in vitro allergy screening

2013 ◽  
Vol 3 (10) ◽  
pp. 782-787 ◽  
Author(s):  
Jeanne L. Hatcher ◽  
Samuel D. Cohen ◽  
J. Whit Mims
Keyword(s):  
Immunoglobulin E ◽  
Serum Immunoglobulin ◽  
Total Serum

Prevalence of Airway Symptoms and Total Serum Immunoglobulin E Among Hairdressers in Bergen:

2003 ◽  
Vol 45 (11) ◽  
pp. 1201-1206 ◽  
Author(s):  
Bjørg Eli Hollund ◽  
Bente Elisabeth Moen ◽  
Grace M. Egeland ◽  
Erik Florvaag
Keyword(s):  
Immunoglobulin E ◽  
Serum Immunoglobulin ◽  
Total Serum ◽  
Airway Symptoms

Diagnosis and Management of Severe Asthma

2018 ◽  
Vol 39 (01) ◽  
pp. 091-099 ◽  
Author(s):  
Kian Fan Chung
Keyword(s):  
Severe Asthma ◽  
Inhaled Corticosteroids ◽  
Immunoglobulin E ◽  
High Dose ◽  
Blood Eosinophil ◽  
Exhaled Breath ◽  
Eosinophilic Asthma ◽  
Severe Eosinophilic Asthma ◽  
Asthma Patients ◽  
Long Acting

AbstractSevere therapy-resistant asthma has been defined as “asthma which requires treatment with high dose inhaled corticosteroids (ICSs) plus a second controller (and/or systemic corticosteroids) to prevent it from becoming ‘uncontrolled’ or which remains ‘uncontrolled’ despite this therapy”. Patients who usually present with ‘difficult-to-treat asthma’ should first be assessed to determine whether he/she has asthma with the exclusion of other diagnoses and if so, whether the asthma can be classified as severe therapy-resistant. This necessitates an assessment of adherence to medications, confounding factors, and comorbidities. Increasingly, management of severe therapy-resistant asthma will be helped by the determination of phenotypes to optimize responses to existing and new therapies. Severe asthma patients are usually on a combination of high dose ICS and long-acting β-agonist (LABA) and, in addition, are often on a maintenance dose of oral corticosteroids. Phenotyping can be informed by measuring blood eosinophil counts and the level of nitric oxide in exhaled breath, and the use of sputum granulocytic counts. Severe allergic asthma and severe eosinophilic asthma are two defined phenotypes for which there are efficacious targeted biologic therapies currently available, namely anti-immunoglobulin E (IgE) and anti-interleukin (IL)-5 antibodies, respectively. Further progress will be realized with the definition of noneosinophilic or non-T2 phenotypes. It will be important for patients with severe asthma to be ultimately investigated and managed in specialized severe asthma centers.

scholarly journals Multifaceted Analyses of Epidermal Serine Protease Activity in Patients with Atopic Dermatitis

2020 ◽  
Vol 21 (3) ◽  
pp. 913 ◽  
Author(s):  
Hayato Nomura ◽  
Mutsumi Suganuma ◽  
Takuya Takeichi ◽  
Michihiro Kono ◽  
Yuki Isokane ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Serine Protease ◽  
Protease Activity ◽  
Serine Proteases ◽  
Immunoglobulin E ◽  
Total Serum ◽  
Tape Stripping ◽  
Blood Eosinophil ◽  
Peripheral Blood Eosinophil ◽  
Serine Protease Activity

The serine proteases kallikrein-related peptidase (KLK) 5 and KLK7 cleave cell adhesion molecules in the epidermis. Aberrant epidermal serine protease activity is thought to play an important role in the pathogenesis of atopic dermatitis (AD). We collected the stratum corneum (SC) from healthy individuals (n = 46) and AD patients (n = 63) by tape stripping and then measuring the trypsin- and chymotrypsin-like serine protease activity. We also analyzed the p.D386N and p.E420K of SPINK5 variants and loss-of-function mutations of FLG in the AD patients. The serine protease activity in the SC was increased not only in AD lesions but also in non-lesions of AD patients. We found, generally, that there was a positive correlation between the serine protease activity in the SC and the total serum immunoglobulin E (IgE) levels, serum thymus and activation-regulated chemokine (TARC) levels, and peripheral blood eosinophil counts. Moreover, the p.D386N or p.E420K in SPINK5 and FLG mutations were not significantly associated with the SC’s serine protease activity. Epidermal serine protease activity was increased even in non-lesions of AD patients. Such activity was found to correlate with a number of biomarkers of AD. Further investigations of serine proteases might provide new treatments and prophylaxis for AD.

Sign in / Sign up

Export Citation Format

Share Document