Indole as a new tentative marker in exhaled breath for non-invasive blood glucose monitoring of diabetic subjects

2021 ◽  
Author(s):  
Herbert Fink ◽  
Tim Maihöfer ◽  
Jeffrey Bender ◽  
Jochen Schulat
Keyword(s):  
Blood Glucose ◽  
Diabetes Management ◽  
Glucose Monitoring ◽  
Blood Glucose Monitoring ◽  
Glucose Measurement ◽  
Diabetic Patients ◽  
Exhaled Breath ◽  
Invasive Approach ◽  
Test Strips ◽  
Non Invasive

Abstract Blood glucose monitoring (BGM) is the most important part of diabetes management. In classical BGM, glucose measurement by test strips involves invasive finger pricking. We present results of a clinical study that focused on a non-invasive approach based on volatile organic compounds (VOCs) in exhaled breath. Main objective was the discovery of markers for prediction of blood glucose levels (BGL) in diabetic patients. Exhaled breath was measured repeatedly in 60 diabetic patients (30 type 1, 30 type 2) in fasting state and after a standardized meal. Proton Transfer Reaction Time of Flight Mass Spectrometry (PTR-ToF-MS) was used to sample breath every 15 minutes for a total of six hours. BGLs were tested in parallel via BGM test strips. VOC signals were plotted against glucose trends for each subject to identify correlations. Exhaled indole (a bacterial metabolite of tryptophan) showed significant mean correlation to BGL (with negative trend) and significant individual correlation in 36 patients. The type of diabetes did not affect this result. Additional experiments of one healthy male subject by ingestion of lactulose and 13C-labeled glucose (n=3) revealed that exhaled indole does not directly originate from food digestion by intestinal microbiota. As indole has been linked to human glucose metabolism, it might be a tentative marker in breath for non-invasive BGM. Clinical studies with greater diversity are required for confirmation of such results and further investigation of metabolic pathways.

scholarly journals Exhaled Breath Analysis for Diabetes Diagnosis and Monitoring: Relevance, Challenges and Possibilities

Biosensors ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 476
Author(s):  
Kaushiki Dixit ◽  
Somayeh Fardindoost ◽  
Adithya Ravishankara ◽  
Nishat Tasnim ◽  
Mina Hoorfar
Keyword(s):  
Blood Glucose ◽  
Diabetes Management ◽  
Glucose Monitoring ◽  
Breath Analysis ◽  
Blood Glucose Monitoring ◽  
Diabetes Diagnosis ◽  
Exhaled Breath ◽  
Non Invasive ◽  
Exhaled Breath Analysis ◽  
Diabetes Monitoring

With the global population prevalence of diabetes surpassing 463 million cases in 2019 and diabetes leading to millions of deaths each year, there is a critical need for feasible, rapid, and non-invasive methodologies for continuous blood glucose monitoring in contrast to the current procedures that are either invasive, complicated, or expensive. Breath analysis is a viable methodology for non-invasive diabetes management owing to its potential for multiple disease diagnoses, the nominal requirement of sample processing, and immense sample accessibility; however, the development of functional commercial sensors is challenging due to the low concentration of volatile organic compounds (VOCs) present in exhaled breath and the confounding factors influencing the exhaled breath profile. Given the complexity of the topic and the skyrocketing spread of diabetes, a multifarious review of exhaled breath analysis for diabetes monitoring is essential to track the technological progress in the field and comprehend the obstacles in developing a breath analysis-based diabetes management system. In this review, we consolidate the relevance of exhaled breath analysis through a critical assessment of current technologies and recent advancements in sensing methods to address the shortcomings associated with blood glucose monitoring. We provide a detailed assessment of the intricacies involved in the development of non-invasive diabetes monitoring devices. In addition, we spotlight the need to consider breath biomarker clusters as opposed to standalone biomarkers for the clinical applicability of exhaled breath monitoring. We present potential VOC clusters suitable for diabetes management and highlight the recent buildout of breath sensing methodologies, focusing on novel sensing materials and transduction mechanisms. Finally, we portray a multifaceted comparison of exhaled breath analysis for diabetes monitoring and highlight remaining challenges on the path to realizing breath analysis as a non-invasive healthcare approach.

scholarly journals Non-Invasive Blood Glucose Estimation using Handheld Near Infra-Red Device

2019 ◽  
Vol 8 (3S) ◽  
pp. 16-19 ◽  
Keyword(s):  
Blood Glucose ◽  
Near Infrared ◽  
Blood Glucose Measurement ◽  
Partial Least Square ◽  
Least Square ◽  
Blood Glucose Monitoring ◽  
Glucose Measurement ◽  
Coefficient Of Determination ◽  
Diabetic Patients ◽  
Non Invasive

Non-invasive blood glucose measurement would ease everyday life of diabetic patients and may cut the cost involved in their treatments. This project aims at developing a non-invasive blood glucose measurement using NIR (near infrared) spectroscopic device. NIR spectra data and blood glucose levels were collected from 45 participants, resulting 90 samples (75 samples for calibration and 15 samples for testing) in this project. These samples were then used to develop a predictive model using Interval Partial Least Square (IPLS) regression method. The results obtained from this project indicate that the handheld micro NIR has potential use for rapid non-invasive blood glucose monitoring. The coefficient of determination (R 2 ) obtained for calibration/training and testing dataset are respectively 0.9 and 0.91.

Evaluation of the Accuracy and Safety of a Portable Metabolic Heat Conformation-Based Non-invasive Glucose Meter: A Multicentre Clinical Study. (Preprint)

2021 ◽  
Author(s):  
Yuanmeng Xu ◽  
Ang Li ◽  
Chenyang Wu ◽  
Zhanxiao Geng ◽  
Junqing Zhang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Glucose ◽  
Clinical Study ◽  
Glucose Monitoring ◽  
Blood Glucose Monitoring ◽  
Glucose Measurement ◽  
Non Invasive ◽  
Metabolic Heat ◽  
Fasted State ◽  
Glucose Meter

BACKGROUND Non-invasive blood glucose measurement is expected to be an ideal way for glucose monitoring, although most of the methods are under study and yet to be verified in large-scale clinical trials. OBJECTIVE We intend to evaluate the stability, accuracy of the metabolic heat conformation (MHC)-based non-invasive glucometer in a multicentre, self-controlled clinical trial. This device obtained the first medical device registration certificate awarded by the National Medical Products Administration of China (NMPA). METHODS The clinical study was conducted at three sites on 200 subjects who received glucose measurement with a non-invasive glucometer, the Contour Plus blood glucose monitoring system, and venous plasma glucose (VPG) measurements, in a fasted state and at 2 and 4 hours after meals. Trial Registration: ChiCTR1900020523. RESULTS The non-invasive and VPG measurements showed 93.9% (95% CI, 91.7–95.6%) of the values in zone A + B in a Consensus Error Grid. The measurements obtained in a fasted state and at 2 hours after meals are more accurate, with 99.0% and 97.0% of the values in zone A + B, respectively. The proportion of values in zone A + B and the correlation coefficients in subjects who did not receive insulin were 3.1% and 0.0596 higher than in those who received insulin. The accuracy of the non-invasive glucometer was influenced by the level of islet cell function and insulin resistance, which had a correlation coefficient with the MARD of -0.0961 (p=0.020) and -0.1577 (p=0.00012), respectively. CONCLUSIONS The MHC-based non-invasive glucometer demonstrates generally high stability and accuracy in the glucose monitoring of diabetic patients. The calculation model needs to be further explored and optimised for patients with different diabetes subtypes, levels of insulin resistance and insulin secretion capacity. CLINICALTRIAL the name of the trial registry : A multi-center study for evaluating the accuracy and safety of noninvasive glucose meter in people with diabetes or impaired glucose regulation (impaired fasting glucose and impaired glucose tolerance), using an experimental test system as a reference. registration number : ChiCTR1900020523 URL : https://www.chictr.org.cn/showproj.aspx?proj=33857

scholarly journals Non-invasive glucose monitoring devices: A review

2020 ◽  
Vol 9 (6) ◽  
pp. 2609-2618
Author(s):  
Muhammad Farhan Affendi Mohamad Yunos ◽  
Anis Nurashikin Nordin
Keyword(s):  
Blood Glucose ◽  
Near Infrared ◽  
Biological Fluids ◽  
Glucose Monitoring ◽  
Optical Methods ◽  
Blood Glucose Monitoring ◽  
Diabetic Patients ◽  
Monitoring Methods ◽  
Non Invasive ◽  
Monitoring Devices

Diabetes is a growing chronic disease that affect millions of people in the world. Regular monitoring of blood glucose levels in patients is necessary to keep the disease under control. Current methods of blood glucose monitoring devices are typically invasive, causing discomfort to the patients. Non-invasive glucose monitoring devices are a possible game changer for diabetic patients as it reduces discomfort and provides continuous monitoring. This manuscript presents a review of non-invasive glucose biosensors with particular focus on leading technologies available in the market, such as microwave sensing, near-infrared spectroscopy, iontophoresis, and optical methods. This paper intends to describe non-invasive blood glucose monitoring methods using various biological fluids (sweat, saliva, interstitial fluid, urine), highlighting the advantages and drawbacks in latest device development. This review also discusses future trends of glucose detection devices and how it will improve patients’ quality of life.

IoT Based Non Invasive Glucometer Using Optical Method

2017 ◽  
Vol 7 (9) ◽  
pp. 42
Author(s):  
Saina Sunny ◽  
S. Swapna Kumar
Keyword(s):  
Blood Glucose ◽  
Real Time ◽  
Glucose Monitoring ◽  
Blood Glucose Measurement ◽  
Blood Glucose Monitoring ◽  
World Health ◽  
Glucose Measurement ◽  
Body Parts ◽  
Non Invasive ◽  
The World

Analysis and measurement of Diabetes Mellitus (DM) became one of the critical challenges of the coming future. Since by 2030, diabetes effected are increased to 360 million all over the world by the World Health Organization (WHO) analytical study survey results. The main aim of this paper is non invasive and continuous glucose monitoring with the IoT technology involvement. Traditional finger pricking methods pros and cons are notified and tried to rectify its demerits. The designed device consist of an infrared led having a wavelength of 900 to 1100nm for the optical blood glucose measurement. NIR photodiodes used to collect light collected from body parts and regressive analysis is carried out. The signal processing, data algorithm is based on Beer-Lambert’s law. In assistance with internet of things (IoT) in WiFi range push alerts are reached to the patients and their concerns on real time. Therefore, it helps in emergency, continuous real time blood glucose monitoring. An IOT based noninvasive glucose monitoring will be a milestone for emerging and smart generation.

Non-Invasive Blood Glucose Monitoring by Means of near Infrared Spectroscopy: Methods for Improving the Reliability of the Calibration Models

1997 ◽  
Vol 20 (5) ◽  
pp. 285-290 ◽  
Author(s):  
U.A. Müller ◽  
B. Mertes ◽  
C. Fischbacher ◽  
K.U. Jageman ◽  
K. Danzer
Keyword(s):  
Blood Glucose ◽  
Near Infrared ◽  
Glucose Monitoring ◽  
Blood Glucose Monitoring ◽  
Least Squares Regression ◽  
Non Invasive ◽  
Infrared Reflection ◽  
Calibration Models ◽  
Infrared Reflection Spectroscopy

The feasibility of using near infrared reflection spectroscopy for non-invasive blood glucose monitoring is discussed. Spectra were obtained using a diode-array spectrometer with a fiberoptic measuring head with a wavelength ranging from 800 nm to 1350 nm. Calibration was performed using partial least-squares regression and radial basis function networks. The results of different methods used to evaluate the quality of the recorded spectra in order to improve the reliability of the calibration models, are presented.

scholarly journals A Review of Non-Invasive Optical Systems for Continuous Blood Glucose Monitoring

Sensors ◽  
2021 ◽  
Vol 21 (20) ◽  
pp. 6820
Author(s):  
Bushra Alsunaidi ◽  
Murad Althobaiti ◽  
Mahbubunnabi Tamal ◽  
Waleed Albaker ◽  
Ibraheem Al-Naib
Keyword(s):  
Blood Glucose ◽  
Glucose Monitoring ◽  
Daily Basis ◽  
Glucose Sensing ◽  
Blood Glucose Monitoring ◽  
Optical Systems ◽  
Glucose Levels ◽  
Non Invasive ◽  
Blood Glucose Levels ◽  
Continuous Blood Glucose Monitoring

The prevalence of diabetes is increasing globally. More than 690 million cases of diabetes are expected worldwide by 2045. Continuous blood glucose monitoring is essential to control the disease and avoid long-term complications. Diabetics suffer on a daily basis with the traditional glucose monitors currently in use, which are invasive, painful, and cost-intensive. Therefore, the demand for non-invasive, painless, economical, and reliable approaches to monitor glucose levels is increasing. Since the last decades, many glucose sensing technologies have been developed. Researchers and scientists have been working on the enhancement of these technologies to achieve better results. This paper provides an updated review of some of the pioneering non-invasive optical techniques for monitoring blood glucose levels that have been proposed in the last six years, including a summary of state-of-the-art error analysis and validation techniques.

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