scholarly journals A novel approach for characterising the cause of disc formation by the shear cutting process in a punching machine

2021 ◽  
Vol 1157 (1) ◽  
pp. 012070
Author(s):  
S Niessner ◽  
M Liewald
Sensors ◽  
2020 ◽  
Vol 20 (16) ◽  
pp. 4493
Author(s):  
Rui Silva ◽  
António Araújo

Condition monitoring is a fundamental part of machining, as well as other manufacturing processes where, generally, there are parts that wear out and have to be replaced. Devising proper condition monitoring has been a concern of many researchers, but there is still a lack of robustness and efficiency, most often hindered by the system’s complexity or otherwise limited by the inherent noisy signals, a characteristic of industrial processes. The vast majority of condition monitoring approaches do not take into account the temporal sequence when modelling and hence lose an intrinsic part of the context of an actual time-dependent process, fundamental to processes such as cutting. The proposed system uses a multisensory approach to gather information from the cutting process, which is then modelled by a recurrent neural network, capturing the evolutive pattern of wear over time. The system was tested with realistic cutting conditions, and the results show great effectiveness and accuracy with just a few cutting tests. The use of recurrent neural networks demonstrates the potential of such an approach for other time-dependent industrial processes under noisy conditions.


Procedia CIRP ◽  
2015 ◽  
Vol 31 ◽  
pp. 88-93 ◽  
Author(s):  
Frederik Zanger ◽  
Nikolay Boev ◽  
Volker Schulze

2019 ◽  
Vol 476 (24) ◽  
pp. 3705-3719 ◽  
Author(s):  
Avani Vyas ◽  
Umamaheswar Duvvuri ◽  
Kirill Kiselyov

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.


2020 ◽  
Vol 51 (3) ◽  
pp. 544-560 ◽  
Author(s):  
Kimberly A. Murphy ◽  
Emily A. Diehm

Purpose Morphological interventions promote gains in morphological knowledge and in other oral and written language skills (e.g., phonological awareness, vocabulary, reading, and spelling), yet we have a limited understanding of critical intervention features. In this clinical focus article, we describe a relatively novel approach to teaching morphology that considers its role as the key organizing principle of English orthography. We also present a clinical example of such an intervention delivered during a summer camp at a university speech and hearing clinic. Method Graduate speech-language pathology students provided a 6-week morphology-focused orthographic intervention to children in first through fourth grade ( n = 10) who demonstrated word-level reading and spelling difficulties. The intervention focused children's attention on morphological families, teaching how morphology is interrelated with phonology and etymology in English orthography. Results Comparing pre- and posttest scores, children demonstrated improvement in reading and/or spelling abilities, with the largest gains observed in spelling affixes within polymorphemic words. Children and their caregivers reacted positively to the intervention. Therefore, data from the camp offer preliminary support for teaching morphology within the context of written words, and the intervention appears to be a feasible approach for simultaneously increasing morphological knowledge, reading, and spelling. Conclusion Children with word-level reading and spelling difficulties may benefit from a morphology-focused orthographic intervention, such as the one described here. Research on the approach is warranted, and clinicians are encouraged to explore its possible effectiveness in their practice. Supplemental Material https://doi.org/10.23641/asha.12290687


2015 ◽  
Vol 21 ◽  
pp. 128
Author(s):  
Kaniksha Desai ◽  
Halis Akturk ◽  
Ana Maria Chindris ◽  
Shon Meek ◽  
Robert Smallridge ◽  
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Keyword(s):  

2002 ◽  
Vol 12 (1) ◽  
pp. 27-41 ◽  
Author(s):  
Y. Zamachtchikov ◽  
F. Breaban ◽  
P. Vantomme ◽  
A. Deffontaine

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