Mechanical characterization of bioprinted in vitro soft tissue models

2013 ◽  
Vol 5 (4) ◽  
pp. 045010 ◽  
Author(s):  
Ting Zhang ◽  
Karen Chang Yan ◽  
Liliang Ouyang ◽  
Wei Sun
2005 ◽  
Vol 33 (11) ◽  
pp. 1631-1639 ◽  
Author(s):  
Ahmad S. Khalil ◽  
Raymond C. Chan ◽  
Alexandra H. Chau ◽  
Brett E. Bouma ◽  
Mohammad R. Kaazempur Mofrad

2019 ◽  
Vol 39 (6) ◽  
pp. 817-826
Author(s):  
Shima Zaeimdar ◽  
Parvind Kaur Grewal ◽  
Zahra Haeri ◽  
Farid Golnaraghi

2011 ◽  
Vol 44 (9) ◽  
pp. 1678-1683 ◽  
Author(s):  
Sagar Umale ◽  
Simon Chatelin ◽  
Nicolas Bourdet ◽  
Caroline Deck ◽  
Michele Diana ◽  
...  

2016 ◽  
Vol 16 (08) ◽  
pp. 1640016 ◽  
Author(s):  
JING YANG ◽  
LINGTAO YU ◽  
LAN WANG ◽  
HONGYANG LI ◽  
QI AN

In recent years, virtual surgical simulation has been one of the hot direction of digital medical research, it is mainly used in teaching, training, diagnosis, preoperative planning, rehabilitation and modeling and analysis of surgical instruments. The modeling of soft tissue of human organs is the basis to realize the virtual surgical simulation. The quasi-linear viscoelastic (QLV) theory has been proposed by Fung, and it was widely used for modeling the constitutive equation of soft tissues. The purpose of this study is to determine the mechanical characterization of the liver soft tissue based on the PHANTOM Omni Haptic devices. Five parameters are included in the constitutive equation with QLV theory, which must be determined experimentally. The specimens were obtained from fresh porcine liver tissues in vitro. The liver tissues were cut into 14[Formula: see text]mm[Formula: see text][Formula: see text][Formula: see text]14[Formula: see text]mm[Formula: see text][Formula: see text][Formula: see text]14[Formula: see text]mm cubes. Two types of unconfined compression tests were performed on cube liver specimens. Puncture tests were performed on the complete liver. The material parameters of the QLV constitutive equation were obtained by fitting the experimental data. These parameters will provide the references for the computational modeling of the liver in the virtual surgical simulation.


2008 ◽  
Vol 71 (12) ◽  
pp. 610-618
Author(s):  
Hsiang-Ning Luk ◽  
Chu-Pin Lo ◽  
Hui-Chun Tien ◽  
Daniel Lee ◽  
Zong-Li Chen ◽  
...  

2021 ◽  
Vol 7 (2) ◽  
pp. 743-746
Author(s):  
Stefan Siewert ◽  
Rudolf Guthoff ◽  
Frank Kamke ◽  
Swen Grossmann ◽  
Michael Stiehm ◽  
...  

Abstract Implant devices for micro invasive glaucoma surgery (MIGS) are gaining increasing acceptance in clinical ophthalmic use. The implant requirements are defined in international standards, such as ANSI Z80.27-2014 and the 2015 Guidance for Industry and Food and Drug Administration Staff “Premarket Studies of Implantable Minimally Invasive Glaucoma Surgical (MIGS) Devices”. The exact fluid-mechanical characterization represents a crucial part of the development and approval of innovative implant devices for MIGS. The current work describes the development and preliminary validation of a versatile test facility for pivotal characterization of glaucoma drainage devices. The test setup enables a pressurization of test specimens by means of two water columns. For measurement of pressure and volume flow, a pressure transducer and a total of three liquid flow meters were implemented into the test setup. Validation was conducted by experimental pressureflow characterization of standardized tubes and a comparison to theoretical results according to Hagen Poiseuille's law for stationary laminar flow of a Newtonian fluid in a tube with a circular cross section. Ultrapure water at (35 ± 2) °C was used for the analyses. The developed test setup potentially enables pressure-flow characterization of test specimens in a wide flow range of 0 μl min-1 ≤ Q ≤ 5.000 μl min-1. The preliminary test facility validation showed a good agreement of measured and theoretical volume flow characteristics as a function of the pressure difference, in the currently investigated flow range of Q < 80 μl min-1. The developed test facility is suitable for pivotal in vitro characterization of glaucoma drainage devices. Future investigations will focus on the final validation of the whole flow range and on the use of the test facility for fluid-mechanical characterization of self-developed prototypes of glaucoma microstents as well as commercially available glaucoma drainage devices.


2013 ◽  
Vol 52 (10) ◽  
pp. 1007-1015 ◽  
Author(s):  
Iqbal Mokhtar ◽  
Mohd Yazid Yahya ◽  
Mohammed Rafiq Abdul Kadir

2018 ◽  
Vol 56 (12) ◽  
pp. 2233-2244 ◽  
Author(s):  
María Prados-Privado ◽  
Sérgio A. Gehrke ◽  
Rosa Rojo ◽  
Juan Carlos Prados-Frutos

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