A Mouse Model for Evaluation of Capillary Perfusion, Microvascular Permeability, Cortical Blood Flow, and Cortical Edema in the Traumatized Brain

2004 ◽  
Vol 21 (6) ◽  
pp. 741-753 ◽  
Author(s):  
C. Lundblad ◽  
P.O. Grände ◽  
P. Bentzer
2020 ◽  
Vol 16 (S3) ◽  
Author(s):  
Muhammad Ali ◽  
Kaja Falkenhain ◽  
Mohammad Haft‐Javaherian ◽  
Muhammad Murtaza‐Ali ◽  
Brendah N Njiru ◽  
...  

1968 ◽  
Vol 29 (4) ◽  
pp. 828-838 ◽  
Author(s):  
A. A. Hadji-Dimo ◽  
R. Ekberg ◽  
D. H. Ingvar

2015 ◽  
Vol 44 (8) ◽  
pp. 1105-1113
Author(s):  
Hyelin Jeon ◽  
Sungmin Kwak ◽  
Su-Jin Oh ◽  
Hyun Soo Nam ◽  
Doo Won Han ◽  
...  

2015 ◽  
Vol 12 (10) ◽  
pp. 914-922 ◽  
Author(s):  
Maximilian Wiesmann ◽  
Carmen Capone ◽  
Valerio Zerbi ◽  
Laura Mellendijk ◽  
Arend Heerschap ◽  
...  

1996 ◽  
Vol 33 (3) ◽  
pp. 127-131 ◽  
Author(s):  
Zvi Zemishlany ◽  
Gene E. Alexander ◽  
Isak Prohovnik ◽  
Ron G. Goldman ◽  
Sukdeb Mukherjee ◽  
...  

2005 ◽  
Vol 289 (6) ◽  
pp. F1324-F1332 ◽  
Author(s):  
Manish M. Tiwari ◽  
Robert W. Brock ◽  
Judit K. Megyesi ◽  
Gur P. Kaushal ◽  
Philip R. Mayeux

Acute renal failure (ARF) is a frequent and serious complication of endotoxemia caused by lipopolysaccharide (LPS) and contributes significantly to mortality. The present studies were undertaken to examine the roles of nitric oxide (NO) and caspase activation on renal peritubular blood flow and apoptosis in a murine model of LPS-induced ARF. Male C57BL/6 mice treated with LPS ( Escherichia coli) at a dose of 10 mg/kg developed ARF at 18 h. Renal failure was associated with a significant decrease in peritubular capillary perfusion. Vessels with no flow increased from 7 ± 3% in the saline group to 30 ± 4% in the LPS group ( P < 0.01). Both the inducible NO synthase inhibitor l- N6-1-iminoethyl-lysine (l-NIL) and the nonselective caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp fluoromethylketone (Z-VAD) prevented renal failure and reversed perfusion deficits. Renal failure was also associated with an increase in renal caspase-3 activity and an increase in renal apoptosis. Both l-NIL and Z-VAD prevented these changes. LPS caused an increase in NO production that was blocked by l-NIL but not by Z-VAD. Taken together, these data suggest NO-mediated activation of renal caspases and the resulting disruption in peritubular blood flow are an important mechanism of LPS-induced ARF.


2014 ◽  
Vol 7 (4) ◽  
pp. 545-550 ◽  
Author(s):  
Marcelo Bigliassi ◽  
Vinícius Barreto-Silva ◽  
Thiago Ferreira Dias Kanthack ◽  
Leandro Ricardo Altimari

1957 ◽  
Vol 14 (4) ◽  
pp. 382-399 ◽  
Author(s):  
John S. Meyer ◽  
John Hunter

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