Addition of a Low Fixed Number of CD3+Cells to CD34-Enriched Allografts: Effects on Engraftment, Graft-versus-Host Disease, and Survival after Related and Unrelated Peripheral Stem Cell Transplantation

2003 ◽  
Vol 12 (3) ◽  
pp. 309-320 ◽  
Author(s):  
Martin Goerner ◽  
Renate Weber-Nordt ◽  
Sabine Hoepfner ◽  
Axel Benner ◽  
Thomas Luft ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Graft Versus Host Disease ◽  
Fixed Number ◽  
Host Disease ◽  
Graft Versus Host ◽  
Peripheral Stem Cell ◽  
Peripheral Stem Cell Transplantation

Donor-derived CMV-specific T cells reduce the requirement for CMV-directed pharmacotherapy after allogeneic stem cell transplantation

Blood ◽  
2013 ◽  
Vol 121 (18) ◽  
pp. 3745-3758 ◽  
Author(s):  
Emily Blyth ◽  
Leighton Clancy ◽  
Renee Simms ◽  
Chun K. K. Ma ◽  
Jane Burgess ◽  
...  
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Graft Versus Host Disease ◽  
Allogeneic Stem Cell Transplantation ◽  
Organ Damage ◽  
Host Disease ◽  
Graft Versus Host ◽  
Key Points

Key Points Infusion of CMV-specific T cells early posttransplant does not increase acute or chronic graft-versus-host disease. CMV-specific T cells early posttransplant reduce the need for pharmacotherapy without increased rates of CMV-related organ damage.

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