Rapid Genetic Characterization of HIV Type 1 Strains from Four World Health Organization-Sponsored Vaccine Evaluation Sites Using a Heteroduplex Mobility Assay

1994 ◽  
Vol 10 (11) ◽  
pp. 1345-1353 ◽  
Author(s):  
MICHAEL H. BACHMANN ◽  
ERIC L. DELWART ◽  
EUGENE G. SHPAER ◽  
PATRICIA LINGENFELTER ◽  
RAHUL SINGAL ◽  
...  
Keyword(s):  
World Health Organization ◽  
Genetic Characterization ◽  
World Health ◽  
Heteroduplex Mobility Assay ◽  
Hiv Type 1 ◽  
Health Organization

scholarly journals Shedding of Vaccine Viruses with Increased Antigenic and Genetic Divergence after Vaccination of Newborns with Monovalent Type 1 Oral Poliovirus Vaccine

2009 ◽  
Vol 83 (17) ◽  
pp. 8693-8704 ◽  
Author(s):  
Sabine van der Sanden ◽  
Mark A. Pallansch ◽  
Jan van de Kassteele ◽  
Nasr El-Sayed ◽  
Roland W. Sutter ◽  
...  
Keyword(s):  
Genetic Characterization ◽  
Oral Poliovirus Vaccine ◽  
World Health ◽  
Study Group ◽  
Poliovirus Type ◽  
The World ◽  
Birth Dose ◽  
Health Organization

ABSTRACT For the final stages in the eradication of poliovirus type 1 (P1), the World Health Organization advocates the selective use of monovalent type 1 oral poliovirus vaccine (mOPV1). To compare the immunogenicity of mOPV1 with that of trivalent OPV (tOPV) in infants, a study was performed in Egypt in 2005. Newborns were vaccinated with mOPV1 or tOPV immediately after birth and were challenged with mOPV1 after 1 month. Vaccination with mOPV1 at birth resulted in significantly higher seroconversion against P1 viruses and lower excretion of P1 viruses than vaccination with tOPV. Intratypic differentiation of the viruses shed by the newborns revealed the presence of remarkably high numbers of antigenically divergent (AD) P1 isolates, especially in the mOPV1 study group. The majority of these AD P1 isolates (71%) were mOPV1 challenge derived and were shed by newborns who did not seroconvert to P1 after the birth dose. Genetic characterization of the viruses revealed that amino acid 60 of the VP3 region was mutated in all AD P1 isolates. Isolates with substitution of residue 99 of the VP1 region had significantly higher numbers of nonsynonymous mutations in the VP1 region than isolates without this substitution and were preferentially shed in the mOPV1 study group. The widespread use of mOPV1 has proven to be a powerful tool for fighting poliovirus circulation in the remaining areas of endemicity. This study provides another justification for the need to achieve high vaccination coverage in order to prevent the circulation of AD strains.

Antigenic Variation and Serotyping of HIV Type 1 from Four World Health Organization-Sponsored HIV Vaccine Sites

1994 ◽  
Vol 10 (11) ◽  
pp. 1369-1377 ◽  
Author(s):  
CHOU-PONG PAU ◽  
MAMIKO KAI ◽  
DEBRA L. HOLLOMAN-CANDAL ◽  
CHI-CHENG LUO ◽  
MARCIA L. KALISH ◽  
...  
Keyword(s):  
World Health Organization ◽  
Antigenic Variation ◽  
Hiv Vaccine ◽  
World Health ◽  
Hiv Type 1 ◽  
Health Organization

Team Rubicon Medical Response to Hurricane Dorian in the Bahamas

2019 ◽  
Vol 13 (5-6) ◽  
pp. 1086-1089
Author(s):  
Andrew J. Bouland ◽  
Jordan Selzer ◽  
Madi Yogman ◽  
David W. Callaway
Keyword(s):  
World Health Organization ◽  
World Health ◽  
Medical Team ◽  
The Bahamas ◽  
Emergency Medical Team ◽  
Medical Response ◽  
Medical Clinics ◽  
The Government ◽  
Health Organization

ABSTRACTOn September 1, 2019, Hurricane Dorian made landfall as a category 5 hurricane on Great Abaco Island, Bahamas. Hurricane Dorian matched the “Labor Day” hurricane of 1935 as the strongest recorded Atlantic hurricane to make landfall with maximum sustained winds of 185 miles/h.1 At the request of the Government of the Bahamas, Team Rubicon activated a World Health Organization Type 1 Mobile Emergency Medical Team and responded to Great Abaco Island. The team provided medical care and reconnaissance of medical clinics on the island and surrounding cays…

scholarly journals Genetic characterization of three CRF01_AE full-length HIV type 1 sequences from Fujian Province, China

2006 ◽  
Vol 119 (19) ◽  
pp. 1622-1628 ◽  
Author(s):  
Hai-long HUANG ◽  
Ping-ping YAN ◽  
Jian ZHENG ◽  
Shou-li WU ◽  
Ge CHENG ◽  
...  
Keyword(s):  
Genetic Characterization ◽  
Full Length ◽  
Fujian Province ◽  
Hiv Type 1

scholarly journals Genetic Characterization of HIV Type 1 Nef-Induced Vesicle Secretion

2010 ◽  
Vol 26 (2) ◽  
pp. 173-192 ◽  
Author(s):  
Syed A. Ali ◽  
Ming-Bo Huang ◽  
Patrick E. Campbell ◽  
William W. Roth ◽  
Tamika Campbell ◽  
...  
Keyword(s):  
Genetic Characterization ◽  
Hiv Type 1 ◽  
Vesicle Secretion

Genetic Characterization of Full-Length HIV Type 1 Genomes From 3 Infected Paid Blood Donors in Henan, China

2005 ◽  
Vol 40 (4) ◽  
pp. 501-503 ◽  
Author(s):  
Li Liu ◽  
Bo Su ◽  
Ke Zhuang ◽  
Po Tien ◽  
Zhiwei Chen ◽  
...  
Keyword(s):  
Blood Donors ◽  
Genetic Characterization ◽  
Full Length ◽  
Hiv Type 1
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