scholarly journals HIV Type 1 Subtype C Drug Resistance among Pediatric and Adult South African Patients Failing Antiretroviral Therapy

2008 ◽  
Vol 24 (11) ◽  
pp. 1449-1454 ◽  
Author(s):  
Visva Pillay ◽  
Candice Pillay ◽  
Rami Kantor ◽  
Francois Venter ◽  
Leon Levin ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
South African ◽  
Subtype C ◽  
Hiv Type 1 ◽  
African Patients

scholarly journals Prevalence of HIV Drug Resistance Mutations in HIV Type 1 Isolates in Antiretroviral Therapy Naïve Population from Northern India

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
S. Sinha ◽  
H. Ahmad ◽  
R. C. Shekhar ◽  
N. Kumar ◽  
L. Dar ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
Resistance Mutations ◽  
Subtype C ◽  
Hiv Drug Resistance ◽  
Northern India ◽  
Subtype B ◽  
Hiv Type 1 ◽  
Hiv 1

Objective. The increased use of antiretroviral therapy (ART) has reduced the morbidity and mortality associated with HIV, adversely leading to the emergence of HIV drug resistance (HIVDR). In this study we aim to evaluate the prevalence of HIVDR mutations in ART-naive HIV-1 infected patients from northern India.Design. Analysis was performed using Viroseq genotyping system based on sequencing of entire protease and two-thirds of the Reverse Transcriptase (RT) region ofpolgene.Results. Seventy three chronic HIV-1 infected ART naïve patients eligible for first line ART were enrolled from April 2006 to August 2008. In 68 patients DNA was successfully amplified and sequencing was done. 97% of HIV-1 strains belonged to subtype C, and one each to subtype A1 and subtype B. The overall prevalence of primary DRMs was 2.9% [2/68, 95% confidence interval (CI), 0.3%–10.2%]. One patient had a major RT mutation M184V, known to confer resistance to lamivudine, and another had a major protease inhibitor (PI) mutation D30N that imparts resistance to nelfinavir.Conclusion. Our study shows that primary HIVDR mutations have a prevalence of 2.9% among ART-naive chronic HIV-1 infected individuals.

scholarly journals K103N Mutation in Antiretroviral Therapy--Naive African Patients Infected with HIV Type 1

2004 ◽  
Vol 39 (4) ◽  
pp. 575-578 ◽  
Author(s):  
O. Akinsete ◽  
D. Hirigoyen ◽  
C. Cartwright ◽  
R. Schut ◽  
R. Kantor ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Hiv Type 1 ◽  
K103n Mutation ◽  
African Patients

Drug Resistance in Plasma and Breast Milk after Single-Dose Nevirapine in Subtype C HIV Type 1: Population and Clonal Sequence Analysis

2007 ◽  
Vol 23 (8) ◽  
pp. 1055-1061 ◽  
Author(s):  
Seble Kassaye ◽  
Esther Lee ◽  
Rami Kantor ◽  
Elizabeth Johnston ◽  
Mark Winters ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Single Dose ◽  
Sequence Analysis ◽  
Breast Milk ◽  
Subtype C ◽  
Single Dose Nevirapine ◽  
Hiv Type 1 ◽  
Clonal Sequence

Efavirenz Plasma Concentrations at 1, 3, and 6 Months Post-Antiretroviral Therapy Initiation in HIV Type 1-Infected South African Children

2010 ◽  
Vol 26 (6) ◽  
pp. 613-619 ◽  
Author(s):  
Michelle Viljoen ◽  
Hermien Gous ◽  
Herculina S. Kruger ◽  
Alison Riddick ◽  
Tammy M. Meyers ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
South African ◽  
Plasma Concentrations ◽  
African Children ◽  
Therapy Initiation ◽  
Hiv Type 1 ◽  
South African Children

scholarly journals HIV type 1 drug resistance patterns among patients failing first and second line antiretroviral therapy in Nairobi, Kenya

2014 ◽  
Vol 7 (1) ◽  
pp. 890 ◽  
Author(s):  
Peter Koigi ◽  
Musa Ngayo ◽  
Samoel Khamadi ◽  
Caroline Ngugi ◽  
Anthony Nyamache
Keyword(s):  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
Second Line ◽  
Resistance Patterns ◽  
Hiv Type 1 ◽  
Second Line Antiretroviral Therapy

scholarly journals Drug Resistance Mutations in HIV Type 1 Isolates from Patients Failing Antiretroviral Therapy in Morocco

2012 ◽  
Vol 28 (8) ◽  
pp. 944-948 ◽  
Author(s):  
Hicham El Annaz ◽  
Patricia Recordon-Pinson ◽  
Rida Tagajdid ◽  
Toufik Doblali ◽  
Bouchra Belefquih ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
Resistance Mutations ◽  
Drug Resistance Mutations ◽  
Hiv Type 1

scholarly journals Stable and Low Prevalence of Transmitted HIV Type 1 Drug Resistance Despite Two Decades of Antiretroviral Therapy in Hong Kong

2010 ◽  
Vol 26 (10) ◽  
pp. 1079-1085 ◽  
Author(s):  
K.H. Wong ◽  
W.K. Chan ◽  
W.C. Yam ◽  
J.H.K. Chen ◽  
F.R. Alvarez-Bognar ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Hong Kong ◽  
Antiretroviral Therapy ◽  
Hiv Type 1 ◽  
Low Prevalence
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