The search for causes of Reye syndrome has resulted in colorful, if not controversial, incrimination of numerous factors including influenza, varicella, environmental toxins, aflotoxin, inherited metabolic defects, and various medications. Attempts to associate salicylates with Reye syndrome date from the 1960s1-3; most of these reports lacked sufficient design, conduct, or controls to implicate or exclude aspirin as a risk factor. Since 1980, several epidemiologic studies4-6 renewed concern and controversy regarding the role of aspirin in Reye syndrome. As a result, a Public Health Service Task Force was formed which culminated in the Centers for Disease Control/National Academy of Sciences pilot study7 which was designed to address the problems and shortcomings identified in the previous efforts to examine the role of aspirin as a causal factor in Reye syndrome.
Recommendations of the U.S. Public Health Service Task Force on the Use of Zidovudine to Reduce Perinatal Transmission of Human Immunodeficiency Virus