Aspirin Use and Reye Syndrome

PEDIATRICS ◽  
1987 ◽  
Vol 79 (6) ◽  
pp. 1049-1050
Author(s):  
RALPH E. KAUFFMAN ◽  
ROBERT J. ROBERTS
Keyword(s):  
Public Health ◽  
Public Health Service ◽  
Task Force ◽  
Environmental Toxins ◽  
Reye Syndrome ◽  
National Academy Of Sciences ◽  
Metabolic Defects ◽  
Academy Of Sciences ◽  
Service Task

The search for causes of Reye syndrome has resulted in colorful, if not controversial, incrimination of numerous factors including influenza, varicella, environmental toxins, aflotoxin, inherited metabolic defects, and various medications. Attempts to associate salicylates with Reye syndrome date from the 1960s1-3; most of these reports lacked sufficient design, conduct, or controls to implicate or exclude aspirin as a risk factor. Since 1980, several epidemiologic studies4-6 renewed concern and controversy regarding the role of aspirin in Reye syndrome. As a result, a Public Health Service Task Force was formed which culminated in the Centers for Disease Control/National Academy of Sciences pilot study7 which was designed to address the problems and shortcomings identified in the previous efforts to examine the role of aspirin as a causal factor in Reye syndrome.

Kawasaki Syndrome, Reye Syndrome, and Aspirin

PEDIATRICS ◽  
1986 ◽  
Vol 77 (4) ◽  
pp. 616-617
Author(s):  
MASATO TAKAHASHI ◽  
WILBERT MASON
Keyword(s):  
Public Health ◽  
Low Dose ◽  
Public Health Service ◽  
Task Force ◽  
Kawasaki Syndrome ◽  
Reye Syndrome ◽  
Dark Cloud ◽  
The Public ◽  
Epidemiologic Features ◽  
Service Task

To the Editor.— Aspirin is the mainstay of therapy for Kawasaki syndrome. Its early initiation and continued low-dose therapy have been effective in reducing morbidity and mortality.1 However, a dark cloud of fear has arisen for those physicians and parents involved with Kawasaki syndrome. A number of reports, including a pilot study by the Public Health Service Task Force, cite association between use of aspirin and Reye syndrome.2 Let us examine epidemiologic features of both syndromes.

The Pediatrician and Genetic Screening (Every Pediatrician a Geneticist)

PEDIATRICS ◽  
1976 ◽  
Vol 58 (5) ◽  
pp. 757-764
Author(s):  
Keyword(s):  
American Academy ◽  
Genetic Screening ◽  
Large Scale ◽  
Task Force ◽  
Hereditary Disease ◽  
Screening Tests ◽  
National Academy Of Sciences ◽  
American Academy Of Pediatrics ◽  
Academy Of Sciences

From time to time, the American Academy of Pediatrics has issued statements1-3 on the role of screening infants for certain types of hereditary disease. Although these statements remain valid in their broadest objective, some of the specific ways and means have altered with the passage of time. Moreover, society is now more concerned about genetic screening as a public endeavor with a potential not only for good but also for harm. There has been much debate about genetic screening-some of it informed, some of it emotional. In response to the growing concerns about genetic screening, the National Academy of Sciences (NAS) published a comprehensive report on the topic.4 Its recommendations are published as an Appendix to this statement. The American Academy of Pediatrics has convened a Task Force to consider the specific implications of the NAS report and its relevance for pediatricians and their associates. The Task Force's most important recommendation is that a standing committee be established to provide expert, ongoing advice on this pervasive and complex subject. DEFINITIONS AND RATIONALE Screening in the medical context can be informally defined as an investigation initiated for reasons other than in response to a patient's problem or request for help. The formal definition3-7 considers screening as "the presumptive identification of unrecognized disease or defect by the application of tests, examinations or other procedures which can be applied rapidly. Screening tests sort out apparently well persons who probably have a disease from those who probably do not." The screening may be large-scale, and encompass a whole population (mass screening); or it may be selective and directed at a high-risk subgroup.

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