ABM Clinical Protocol #34: Breast Cancer and Breastfeeding

Aims and background Accumulated information on biologic prognostic indicators and predictors of response to different types of treatment in patients with different tumor characteristics has made it possible to design clinical protocols on biologic bases. Among cell proliferation indices, the thymidine labelling index (TLI) has proved to be an independent and consistent prognostic indicator over time. Moreover, experimental and retrospective analyses of clinical studies have revealed a direct relation between TLI and response to chemotherapy. On the basis of the results, a prospective clinical protocol on axillary node-negative breast cancer was activated in Italy in 1989. Methods Patients with low TLI tumors were treated with local-regional therapy alone, whereas patients with high TLI tumors were randomized to receive local-regional therapy followed or not by adjuvant chemotherapy consisting of 6 cycles of CMF. Results and Conclusions The present paper reports on the feasibility of a prospective clinical protocol based on a subgroup of patients with specific pathologic (node negative) and biologic (rapidly proliferating) breast cancers. However, patient eligibility was only 11%.

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ABM Clinical Protocol #34: Breast Cancer and Breastfeeding

Breastfeeding ◽

10.1016/b978-0-323-68013-4.00078-x ◽

2022 ◽

pp. 1038.e11-1038.e17

Author(s):

Helen M. Johnson ◽

Katrina B. Mitchell

Keyword(s):

Breast Cancer ◽

Clinical Protocol

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Incorporation of expert variability into breast cancer treatment recommendation in designing clinical protocol guided fuzzy rule system models

Journal of Biomedical Informatics ◽

10.1016/j.jbi.2011.12.007 ◽

2012 ◽

Vol 45 (3) ◽

pp. 447-459 ◽

Cited By ~ 18

Author(s):

Jonathan M. Garibaldi ◽

Shang-Ming Zhou ◽

Xiao-Ying Wang ◽

Robert I. John ◽

Ian O. Ellis

Keyword(s):

Breast Cancer ◽

Cancer Treatment ◽

Fuzzy Rule ◽

Breast Cancer Treatment ◽

Treatment Recommendation ◽

Clinical Protocol ◽

System Models ◽

Rule System

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MARKETING RESEARCH OF THE MEDICINE MARKET FOR THE TREATMENT OF BREAST CANCER IN UKRAINE

Ukrainian Scientific Medical Youth Journal ◽

10.32345/usmyj.4(127).2021.77-83 ◽

2021 ◽

Vol 127 (4) ◽

pp. 77-83

Author(s):

Yaroslava Rafalska ◽

Kostyantin Kosyachenko

Keyword(s):

Breast Cancer ◽

Great Britain ◽

Musculoskeletal System ◽

Dosage Form ◽

Marketing Research ◽

Dosage Forms ◽

Immunomodulatory Drugs ◽

Clinical Protocol

the article presents the results of the study of the marketing market of medicines for the treatment of breast cancer in Ukraine during 2019-2020. Medicine treatment schemes based on a clinical protocol were analyzed. On December 1, 2019, 184 drugs were registered for the treatment of breast cancer in Ukraine, and on December 1, 2020 - 194. In 2020, the largest share among of the studied drugs belongs to the group of antineoplastic and immunomodulatory drugs - 82.0 %, and the group of drugs that affect the musculoskeletal system - 18.0 %. On December 1, 2020, drugs were represented by 43 manufacturers, of which 18.6 % were Ukrainian and 81.4 % were foreign. Among Ukrainian companies, the primacy belongs to Pharmex Group LLC (4.1 %), Teva Ukraine LLC (3.1 %) and Farmak JSC (2.6 %). The largest share of foreign suppliers occupies Great Britain - 26.3 %, Switzerland and India by 11.9 %. At that time, in 5 pharmacotherapeutic groups (L01AA01, L01BA01, L01CA04, L01XC07, M05BA03) is not represented by any drug Ukrainian manufacturer. Analysis of the assortment of drugs for the treatment of breast cancer by dosage form in 2020 showed that the main share (35.6 %) is represented by concentrate for solution for infusion, 21.6 % - tablets and 20.6 % - lyophilisate for solution for infusion. Other dosage forms form a total of 22.2 % of the total assortment of drugs, studied in the Ukrainian market.

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Re: “ABM Clinical Protocol #34: Breast Cancer and Breastfeeding” by Johnson HM, et al.

Breastfeeding Medicine ◽

10.1089/bfm.2020.0250 ◽

2020 ◽

Vol 15 (12) ◽

pp. 813-813

Author(s):

Ilana R. Azulay Chertok ◽

Jacqueline H. Wolf ◽

Shana Beigelman ◽

Ellen Warner

Keyword(s):

Breast Cancer ◽

Clinical Protocol

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Virus-Like Particles in a Human Breast Cancer: Structural Similarity to Previously Reported Particles

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100072332 ◽

1973 ◽

Vol 31 ◽

pp. 378-379

Author(s):

G. Kasnic ◽

S. E. Stewart ◽

C. Urbanski

Keyword(s):

Breast Cancer ◽

Biological Activity ◽

Human Breast Cancer ◽

Osteogenic Sarcoma ◽

Human Tumor ◽

Structural Similarity ◽

Cell Tumor ◽

Human Breast ◽

Human Tumor Cell ◽

Type Particle

We have reported the maturation of an intracisternal A-type particle in murine plasma cell tumor cultures and three human tumor cell cultures (rhabdomyosarcoma, lung adenocarcinoma, and osteogenic sarcoma) after IUDR-DMSO activation. In all of these studies the A-type particle seems to develop into a form with an electron dense nucleoid, presumably mature, which is also intracisternal. A similar intracisternal A-type particle has been described in leukemic guinea pigs. Although no biological activity has yet been demonstrated for these particles, on morphologic grounds, and by the manner in which they develop within the cell, they may represent members of the same family of viruses.

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Further Ultrastructural Observations on Metastatic Nodules of Human Breast Cancer

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010010086x ◽

1968 ◽

Vol 26 ◽

pp. 224-225

Author(s):

John L. Swedo ◽

R. W. Talley ◽

John H. L. Watson

Keyword(s):

Breast Cancer ◽

Human Breast Cancer ◽

Estrogen Therapy ◽

Specimen Preparation ◽

Human Breast ◽

Autophagic Vacuoles ◽

Previous Communication ◽

Linear Profiles ◽

Metastatic Nodule

Since the report, which described the ultrastructure of a metastatic nodule of human breast cancer after estrogen therapy, additional ultrastructural observations, including some which are correlative with pertinent findings in the literature concerning mycoplasmas, have been recorded concerning the same subject. Specimen preparation was identical to that in.The mitochondria possessed few cristae, and were deteriorated and vacuolated. They often contained particulates and fibrous structures, sometimes arranged in spindle-shaped bundles, Fig. 1. Another apparent aberration was the occurrence, Fig. 2 (arrows) of linear profiles of what seems to be SER, which lie between layers of RER, and are often recognizably continuous with them.It was noted that the structure of the round bodies, interpreted as within autophagic vacuoles in the previous communication, and of vesicular bodies, described morphologically closely resembled those of some mycoplasmas. Specifically, they simulated or reflected the various stages of replication reported for mycoplasmas grown on solid nutrient. Based on this observation, they are referred to here as “mycoplasma-like” structures, in anticipation of confirmatory evidence from investigations now in progress.

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