Study of the mechanism responsible for multidrug resistance in breast cancer MCF-7 cell mediated by 14-3-3σ

2010 ◽  
Vol 34 (8) ◽  
pp. S47-S47
Author(s):  
Guopei Zheng ◽  
Sisi Yi ◽  
Yafei Li ◽  
Fangren Kong ◽  
Yanhui Yu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Mcf 7

scholarly journals Induction of multidrug resistance associated protein 2 in tamoxifen-resistant breast cancer cells

2007 ◽  
Vol 14 (2) ◽  
pp. 293-303 ◽  
Author(s):  
Hoo Kyun Choi ◽  
Jin Won Yang ◽  
Sang Hee Roh ◽  
Chang Yeob Han ◽  
Keon Wook Kang
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Transcriptional Activation ◽  
Breast Cancer Cells ◽  
Pregnane X Receptor ◽  
Pi3 Kinase ◽  
Gene Promoters ◽  
Breast Cancer Patients ◽  
Mcf 7

Acquired resistance to tamoxifen (TAM) is a serious therapeutic problem in breast cancer patients. The transition from chemotherapy-responsive breast cancer cells to chemotherapy-resistant cancer cells is mainly accompanied by the increased expression of multidrug resistance-associated proteins (MRPs). In this study, it was found that TAM-resistant MCF-7 (TAMR-MCF-7) cells expressed higher levels of MRP2 than control MCF-7 cells. Molecular analyses using MRP2 gene promoters supported the involvement of the pregnane X receptor (PXR) in MRP2 overexpression in TAMR-MCF-7 cells. Although CCAAT/enhancer-binding protein β was overexpressed continuously in TAMR-MCF-7 cells, this might not be responsible for the transcriptional activation of the MRP2 gene. In addition, the basal activities of phosphatidylinositol 3-kinase (PI3-kinase) were higher in the TAMR-MCF-7 cells than in the control cells. The inhibition of PI3-kinase significantly reduced both the PXR activity and MRP2 expression in TAMR-MCF-7 cells. Overall, MRP2 induction plays a role in the additional acquisition of chemotherapy resistance in TAM-resistant breast cancer.

scholarly journals Psoralen reverses the P-glycoprotein-mediated multidrug resistance in human breast cancer MCF-7/ADR cells

2016 ◽  
Vol 13 (6) ◽  
pp. 4745-4750 ◽  
Author(s):  
JINGRU JIANG ◽  
XIAOHONG WANG ◽  
KAI CHENG ◽  
WANZHONG ZHAO ◽  
YITONG HUA ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Human Breast Cancer ◽  
Human Breast ◽  
P Glycoprotein ◽  
Mcf 7

Reversal of P-glycoprotein-mediated multidrug resistance is induced by saikosaponin D in breast cancer MCF-7/adriamycin cells

2017 ◽  
Vol 213 (7) ◽  
pp. 848-853 ◽  
Author(s):  
Chun Li ◽  
Xingang Guan ◽  
Haogang Xue ◽  
Peng Wang ◽  
Manli Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
P Glycoprotein ◽  
Mcf 7

Matrine reversed multidrug resistance of breast cancer MCF-7/ADR cells through PI3K/AKT signaling pathway

2018 ◽  
Vol 119 (5) ◽  
pp. 3885-3891 ◽  
Author(s):  
Bing-Gang Zhou ◽  
Chang-Sheng Wei ◽  
Song Zhang ◽  
Zhi Zhang ◽  
Huan-min Gao
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Mcf 7

scholarly journals Diltiazem potentiation of doxorubicin cytotoxicity and cellular uptake in human breast cancer cells

2019 ◽  
Vol 8 (4) ◽  
pp. BMT31
Author(s):  
Hamdan S Al-malky ◽  
Zoheir A Damanhouri ◽  
Jumana Y Al Aama ◽  
Ali A Al Qahtani ◽  
Wafaa S Ramadan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Cytotoxic Activity ◽  
Cellular Uptake ◽  
Breast Cancer Cells ◽  
Limiting Factors ◽  
Human Breast ◽  
Common Cancer ◽  
P Glycoprotein ◽  
Mcf 7

Aim: Breast cancer is the most common cancer among Arab women and also around the world. Chronic cardiotoxicity and multidrug resistance are potential limiting factors of doxorubicin (DOX), a known anthracycline antibiotic. Materials & methods: DOX cytotoxicity was evaluated by the sulforhodamine method. DOX cellular uptake, detection of P-glycoprotein activity and the photomicrograph of MCF-7 cells were also determined. Results: Diltiazem (DIL) treatment improved DOX cytotoxic activity and increased the cellular uptake of DOX significantly and aggregation of rhodamine 123, reflecting inhibition of P-glycoprotein pump. Cytopathological investigation of MCF-7 cells revealed marked cytotoxic activity of DOX in the presence of DIL. Conclusion: DIL treatment enhanced DOX cytotoxic effect and reduced multidrug resistance, which increased the drug accumulation intracellularly.

Reductive responsive micelle overcoming multidrug resistance of breast cancer by co-delivery of DOX and specific antibiotic

2019 ◽  
Vol 7 (40) ◽  
pp. 6075-6086 ◽  
Author(s):  
Yani Cui ◽  
Yuedi Yang ◽  
Mengcheng Ma ◽  
Yang Xu ◽  
Junhui Sui ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Multidrug Resistance ◽  
Combination Chemotherapy ◽  
Broad Spectrum ◽  
Antitumor Drug ◽  
Chemotherapy Strategy ◽  
Mcf 7

The redox-degradable nano-micelle-reversed drug resistance by combination chemotherapy strategy of salinomycin (SL) that could specifically inhibit A/MCF-7 cells and a traditional broad-spectrum antitumor drug, doxorubicin (DOX).

A dynamic study on reversal of multidrug resistance by ginsenoside Rh2 in adriamycin-resistant human breast cancer MCF-7 cells

Talanta ◽  
2012 ◽  
Vol 88 ◽  
pp. 345-351 ◽  
Author(s):  
Bei Zhou ◽  
Xiuli Xiao ◽  
Lili Xu ◽  
Lian Zhu ◽  
Liang Tan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Human Breast Cancer ◽  
Dynamic Study ◽  
Ginsenoside Rh2 ◽  
Human Breast ◽  
Mcf 7
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