Administration of Δ9-Tetrahydrocannabinol Following Controlled Cortical Impact Restores Hippocampal-Dependent Working Memory and Locomotor Function

2021 ◽  
Author(s):  
Shijie Song ◽  
Xiaoyuan Kong ◽  
Bangmei Wang ◽  
Juan Sanchez-Ramos
Keyword(s):  
Working Memory ◽  
Controlled Cortical Impact ◽  
Locomotor Function ◽  
Cortical Impact

Traumatic Brain Injury-Induced Excitotoxicity Assessed in a Controlled Cortical Impact Model

1993 ◽  
Vol 61 (6) ◽  
pp. 2015-2024 ◽  
Author(s):  
Alan M. Palmer ◽  
Donald W. Marion ◽  
Michelle L. Botscheller ◽  
Pamela E. Swedlow ◽  
Scott D. Styren ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Impact Model ◽  
Controlled Cortical Impact ◽  
Cortical Impact

Acute Response of the Hippocampal Transcriptome Following Mild Traumatic Brain Injury After Controlled Cortical Impact in the Rat

2015 ◽  
Vol 57 (2) ◽  
pp. 282-303 ◽  
Author(s):  
Babru B. Samal ◽  
Cameron K. Waites ◽  
Camila Almeida-Suhett ◽  
Zheng Li ◽  
Ann M. Marini ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Controlled Cortical Impact ◽  
Acute Response ◽  
Cortical Impact

Atorvastatin reduction of intracranial hematoma volume in rats subjected to controlled cortical impact

2004 ◽  
Vol 101 (5) ◽  
pp. 822-825 ◽  
Author(s):  
Dunyue Lu ◽  
Asim Mahmood ◽  
Changsheng Qu ◽  
Anton Goussev ◽  
Mei Lu ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
Functional Improvement ◽  
Intracranial Hematoma ◽  
Imaging Device ◽  
Controlled Cortical Impact ◽  
Content Type ◽  
Tissue Sections ◽  
Male Wistar Rats ◽  
Cortical Impact ◽  
Fine Print

Object. Atorvastatin, a β-hydroxy-β-methylglutaryl coenzyme A reductase inhibitor, has pleiotropic effects such as improving thrombogenic profile, promoting angiogenesis, and reducing inflammatory responses and has shown promise in enhancing neurological functional improvement and promoting neuroplasticity in animal models of traumatic brain injury (TBI), stroke, and intracranial hemorrhage. The authors tested the effect of atorvastatin on intracranial hematoma after TBI. Methods. Male Wistar rats were subjected to controlled cortical impact, and atorvastatin (1 mg/kg) was orally administered 1 day after TBI and daily for 7 days thereafter. Rats were killed at 1, 8, and 15 days post-TBI. The temporal profile of intraparenchymal hematoma was measured on brain tissue sections by using a MicroComputer Imaging Device and light microscopy. Conclusions. Data in this study showed that intraparenchymal and intraventricular hemorrhages are present 1 day after TBI and are absorbed at 15 days after TBI. Furthermore, atorvastatin reduces the volume of intracranial hematoma 8 days after TBI.

Investigation of tissue level tolerance for cerebral contusion in a controlled cortical impact porcine model

2021 ◽  
pp. 1-7
Author(s):  
Dries De Kegel ◽  
Gracia Umuhire Musigazi ◽  
Andrea Menichetti ◽  
Peter-William Hellings ◽  
Raf Sciot ◽  
...  
Keyword(s):  
Porcine Model ◽  
Tissue Level ◽  
Cerebral Contusion ◽  
Controlled Cortical Impact ◽  
Cortical Impact
Sign in / Sign up

Export Citation Format

Share Document