Quetiapine and Clozapine Combination Treatment for Tourette's Syndrome in an Adolescent Boy: Potential Role of Dopamine Supersensitivity in Loss of Treatment Response

Background. The treatment of Tourette's syndrome (TS) is often unsatisfactory. However, there is some evidence that transdermal nicotine patch (TNP) application may improve tics of non-smoking TS patients who are refractory to haloperidol treatment.Methods. In this open study we applied two 10 mg TNP for 2 consecutive days to four TS patients whose symptoms were not controlled by haloperidol and to a never-medicated TS patient, all of whom are non-smokers. The Yale Global Tic Severity Scale (YGTSS) and a quantified video-taped micro-structured analysis of tics (head-shake tics, eye-blinks, vocal tics, facial grimace and other body tics) were both carried out to assess the change after the application of TNP.Results. TNP application significantly reduced the YGTSS by an average of 50%, with no reported side-effects, for up to 4 weeks but not 16 weeks, as compared with TNP-free period. Consistent with these results, the total counts of tics also showed a significant decrease for up to 4 weeks after the TNP application.Conclusion. TNP application differentially affected individually quantified tics, which may suggest a differential role of nicotinic receptors in the generation of different tics.

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Spontaneous intracranial hypotension following soccer game: potential role of MRI in the treatment response

Turkish Neurosurgery ◽

10.5137/1019-5149.jtn.15549-15.0 ◽

2015 ◽

Author(s):

Turker Acar ◽

Meltem Karacan Golen ◽

Mustafa Golen

Keyword(s):

Treatment Response ◽

Intracranial Hypotension ◽

Potential Role ◽

Spontaneous Intracranial Hypotension ◽

Soccer Game

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The role of mutations on gene SLITRK1, in Tourette’s Syndrome

The Gazette of Medical Sciences ◽

10.46766/thegms.medgen.20100501 ◽

2020 ◽

Vol 1 (5) ◽

pp. 47-51

Author(s):

Shahin Asadi ◽

Keyword(s):

Tourette's Syndrome ◽

Tourette’S Syndrome

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Peran Penerimaan Sosial terhadap Psikopatologi Perkembangan Sindrom Tourette Pada Anak

BUANA GENDER Jurnal Studi Gender dan Anak ◽

10.22515/bg.v1i2.234 ◽

2016 ◽

Vol 1 (2) ◽

pp. 129

Author(s):

Ellen Prima

Keyword(s):

Developmental Psychopathology ◽

Social Acceptance ◽

Tourette's Syndrome ◽

Tourette’S Syndrome ◽

Full Potential ◽

Body Parts ◽

The Social ◽

The Face ◽

Pressure Stress

One of the developmental psychopathology types that often occur in childhood is Tourette's syndrome which begins with mild symptoms such as mild tic movements on the face, head or hands. Tic will often arise when the children feel under pressure (stress) and their emotion is unstable. It increases simultaneously with ones age including legs and other body parts. Tourette's syndrome may infect every one of all ethnic groups. The aim of this study was to identify and describe the role of social acceptance towards the developmental psychopathology of Tourette's syndrome in children. Therefore, this study uses a descriptive qualitative method. The results of this study indicate that the social acceptance (environment) helps a person to adapt well and be able to use his full potential, especially for the person suffering from developmental psychopathology of Tourettes syndrome.Salah satu jenis psikopatologi perkembangan yang sering terjadi pada masa kanak-kanak yaitu sindrom tourette yang diawali dengan gejala ringan seperti gerakan tik ringan pada wajah, kepala atau tangan. Tik sering muncul jika anak merasa tertekan (stres) dan adanya ketidakstabilan emosi. Hal itu semakin meningkat seiring dengan bertambahnya usia seseorang yang mencakup beberapa bagian tubuh lain seperti kaki dan anggota tubuh yang lain. Sindrom tourette dapat terjadi pada setiap orang dari semua kelompok etnis. Tujuan dari penelitian ini adalah untuk mengetahui dan menjelaskan peran penerimaan sosial terhadap psikopatologi perkembangan sindrom Tourette pada anak. Oleh karena itu, penelitian ini menggunakan metode kualitatif jenis deskriptif. Hasil dari penelitian ini menunjukkan bahwa penerimaan secara sosial (lingkungan) sangat membantu seseorang dalam beradaptasi dengan baik dan dapat menggunakan potensinya secara maksimal terutama bagi orang yang mengalami penyimpangan perkembangan salah satunya adalah sindrom tourette.

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