Effect of Allomelanin on Tumor Growth Suppression in vivo and on the Cell Cycle Phase

1997 ◽  
Vol 12 (4) ◽  
pp. 273-276 ◽  
Author(s):  
Hideo Kamei ◽  
Tatsurou Koide ◽  
Yoko Hashimoto ◽  
Takashi Kojima ◽  
Makoto Hasegawa ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Growth ◽  
Growth Suppression ◽  
Cell Cycle Phase ◽  
Cycle Phase ◽  
Tumor Growth Suppression

scholarly journals Nucleosomal histones of transcriptionally active/competent chromatin preferentially exchange with newly synthesized histones in quiescent chicken erythrocytes

1990 ◽  
Vol 271 (1) ◽  
pp. 67-73 ◽  
Author(s):  
M J Hendzel ◽  
J R Davie
Keyword(s):  
Cell Cycle ◽  
Active Component ◽  
Cell Cycle Phase ◽  
Chromatin Remodelling ◽  
Cycle Phase ◽  
Active Chromatin ◽  
Chromatin Domains ◽  
Chromatin Fraction ◽  
Chicken Erythrocytes

The incorporation of newly synthesized histones among various chromatin fraction isolated from non-replicating cell-cycle-phase-Go chicken immature erythrocytes was investigated. We find that newly synthesized erythroid-specific histone Hl variant H5, is incorporated randomly into chromatin. In contrast, newly synthesized nucleosomal histones H2A, H2A.Z, H2B, H3.3, and H4 are preferentially found in a fraction that is highly enriched in active/competent gene chromatin fragments and depleted in repressed gene chromatin. Moreover, ubiquitinated species of histones H2A and H2B and hyperacetylated species of H4 and H2B, which are complexed to active DNA, are labelled. These observations provide evidence that newly synthesized histones preferentially exchange with the nucleosomal histones of transcriptionally active/component chromatin domains. The results of this study suggest that nucleosomes of active chromatin may be inherently less stable than bulk nucleosomes in vivo and have implications for chromatin remodelling.

Cyclometalated Palladium(II) N-Heterocyclic Carbene Complexes: Anticancer Agents for Potent In Vitro Cytotoxicity and In Vivo Tumor Growth Suppression

2016 ◽  
Vol 128 (39) ◽  
pp. 12114-12118 ◽  
Author(s):  
Tommy Tsz-Him Fong ◽  
Chun-Nam Lok ◽  
Clive Yik-Sham Chung ◽  
Yi-Man Eva Fung ◽  
Pui-Keong Chow ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Anticancer Agents ◽  
Growth Suppression ◽  
In Vitro Cytotoxicity ◽  
Carbene Complexes ◽  
Tumor Growth Suppression

Synthesis, X-ray structure, interactions with DNA, remarkable in vivo tumor growth suppression and nephroprotective activity of cis-tetrachloro-dipivalato dirhenium(III)

2013 ◽  
Vol 129 ◽  
pp. 127-134 ◽  
Author(s):  
Natalia I. Shtemenko ◽  
Helen T. Chifotides ◽  
Konstantin V. Domasevitch ◽  
Alexander A. Golichenko ◽  
Svetlana A. Babiy ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Growth Suppression ◽  
X Ray ◽  
Nephroprotective Activity ◽  
Tumor Growth Suppression
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