A Novel Agonistic Anti-Human Death Receptor 5 Monoclonal Antibody with Tumoricidal Activity Induces Caspase- and Mitochondrial-Dependent Apoptosis in Human Leukemia Jurkat Cells

2011 ◽  
Vol 26 (2) ◽  
pp. 143-152 ◽  
Author(s):  
Yao-wu Du ◽  
Ju-gao Chen ◽  
Hui-ling Bai ◽  
Hong-ying Huang ◽  
Jing Wang ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Death Receptor ◽  
Jurkat Cells ◽  
Human Leukemia ◽  
Death Receptor 5 ◽  
Tumoricidal Activity ◽  
Human Death

scholarly journals Thirteen-week Intravenous Toxicity Study of a Novel Humanized Anti-Human Death Receptor 5 Monoclonal Antibody, CS-1008, in Cynomolgus Monkeys

2010 ◽  
Vol 23 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Tomofumi Kimotsuki ◽  
Kohji Tanaka ◽  
Tomomi Sugiura ◽  
Kumiko Koyama ◽  
Takahiro Nakamura ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Death Receptor ◽  
Toxicity Study ◽  
Death Receptor 5 ◽  
Cynomolgus Monkeys ◽  
Human Death

scholarly journals Structural basis of LaDR5, a novel agonistic anti-death receptor 5 (DR5) monoclonal antibody, to inhibit DR5/TRAIL complex formation

2012 ◽  
Vol 13 (1) ◽  
pp. 40
Author(s):  
Chunxia Qiao ◽  
Meiyun Hu ◽  
Leiming Guo ◽  
Ming Lv ◽  
Zhou Lin ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Complex Formation ◽  
Death Receptor ◽  
Structural Basis ◽  
Death Receptor 5

scholarly journals Phase I Trial of Weekly Tigatuzumab, an Agonistic Humanized Monoclonal Antibody Targeting Death Receptor 5 (DR5)

2010 ◽  
Vol 25 (1) ◽  
pp. 13-19 ◽  
Author(s):  
Andres Forero-Torres ◽  
Jatin Shah ◽  
Tina Wood ◽  
James Posey ◽  
Ronda Carlisle ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Phase I ◽  
Phase I Trial ◽  
Death Receptor ◽  
Death Receptor 5 ◽  
Humanized Monoclonal Antibody ◽  
Antibody Targeting

scholarly journals Quantitative Analysis of Ligand-Induced Supramolecular Clustering of Death Receptor 5 in Jurkat Cells

2014 ◽  
Vol 106 (2) ◽  
pp. 715a
Author(s):  
Andrew K. Lewis ◽  
Christopher C. Valley ◽  
Anthony R. Braun ◽  
Jonathan N. Sachs
Keyword(s):  
Quantitative Analysis ◽  
Death Receptor ◽  
Jurkat Cells ◽  
Death Receptor 5

240 Molecular imaging of Death Receptor 5 (DR5) occupancy in-vivo by humanized monoclonal antibody CS-1008

2010 ◽  
Vol 8 (7) ◽  
pp. 78
Author(s):  
A.M. Scott ◽  
F.T. Lee ◽  
G.C. Cartwright ◽  
G.J. O'Keefe ◽  
R.A. Beckman ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Molecular Imaging ◽  
Death Receptor ◽  
Death Receptor 5 ◽  
Humanized Monoclonal Antibody

scholarly journals Promoter structure and transcription initiation sites of the human death receptor 5/TRAIL-R2 gene1

FEBS Letters ◽  
2001 ◽  
Vol 507 (3) ◽  
pp. 381-385 ◽  
Author(s):  
Tatsushi Yoshida ◽  
Ayaka Maeda ◽  
Naoki Tani ◽  
Toshiyuki Sakai
Keyword(s):  
Transcription Initiation ◽  
Death Receptor ◽  
Death Receptor 5 ◽  
Promoter Structure ◽  
Human Death
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