Thirteen-week Intravenous Toxicity Study of a Novel Humanized Anti-Human Death Receptor 5 Monoclonal Antibody, CS-1008, in Cynomolgus Monkeys

Tomofumi Kimotsuki; Kohji Tanaka; Tomomi Sugiura; Kumiko Koyama; Takahiro Nakamura; Yasuhiro Kamimura; Wataru Takasaki; Sunao Manabe

doi:10.1293/tox.23.11

Thirteen-week Intravenous Toxicity Study of a Novel Humanized Anti-Human Death Receptor 5 Monoclonal Antibody, CS-1008, in Cynomolgus Monkeys

Journal of Toxicologic Pathology ◽

10.1293/tox.23.11 ◽

2010 ◽

Vol 23 (1) ◽

pp. 11-17 ◽

Cited By ~ 1

Author(s):

Tomofumi Kimotsuki ◽

Kohji Tanaka ◽

Tomomi Sugiura ◽

Kumiko Koyama ◽

Takahiro Nakamura ◽

...

Keyword(s):

Monoclonal Antibody ◽

Death Receptor ◽

Toxicity Study ◽

Death Receptor 5 ◽

Cynomolgus Monkeys ◽

Human Death

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A Novel Agonistic Anti-Human Death Receptor 5 Monoclonal Antibody with Tumoricidal Activity Induces Caspase- and Mitochondrial-Dependent Apoptosis in Human Leukemia Jurkat Cells

Cancer Biotherapy & Radiopharmaceuticals ◽

10.1089/cbr.2010.0827 ◽

2011 ◽

Vol 26 (2) ◽

pp. 143-152 ◽

Cited By ~ 5

Author(s):

Yao-wu Du ◽

Ju-gao Chen ◽

Hui-ling Bai ◽

Hong-ying Huang ◽

Jing Wang ◽

...

Keyword(s):

Monoclonal Antibody ◽

Death Receptor ◽

Jurkat Cells ◽

Human Leukemia ◽

Death Receptor 5 ◽

Tumoricidal Activity ◽

Human Death

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Structural basis of LaDR5, a novel agonistic anti-death receptor 5 (DR5) monoclonal antibody, to inhibit DR5/TRAIL complex formation

BMC Immunology ◽

10.1186/1471-2172-13-40 ◽

2012 ◽

Vol 13 (1) ◽

pp. 40

Author(s):

Chunxia Qiao ◽

Meiyun Hu ◽

Leiming Guo ◽

Ming Lv ◽

Zhou Lin ◽

...

Keyword(s):

Monoclonal Antibody ◽

Complex Formation ◽

Death Receptor ◽

Structural Basis ◽

Death Receptor 5

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Phase I Trial of Weekly Tigatuzumab, an Agonistic Humanized Monoclonal Antibody Targeting Death Receptor 5 (DR5)

Cancer Biotherapy & Radiopharmaceuticals ◽

10.1089/cbr.2009.0673 ◽

2010 ◽

Vol 25 (1) ◽

pp. 13-19 ◽

Cited By ~ 103

Author(s):

Andres Forero-Torres ◽

Jatin Shah ◽

Tina Wood ◽

James Posey ◽

Ronda Carlisle ◽

...

Keyword(s):

Monoclonal Antibody ◽

Phase I ◽

Phase I Trial ◽

Death Receptor ◽

Death Receptor 5 ◽

Humanized Monoclonal Antibody ◽

Antibody Targeting

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TBCRC 019: A Phase II Trial of Nanoparticle Albumin-Bound Paclitaxel with or without the Anti-Death Receptor 5 Monoclonal Antibody Tigatuzumab in Patients with Triple-Negative Breast Cancer

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-14-2780 ◽

2015 ◽

Vol 21 (12) ◽

pp. 2722-2729 ◽

Cited By ~ 27

Author(s):

Andres Forero-Torres ◽

Katherine E. Varley ◽

Vandana G. Abramson ◽

Yufeng Li ◽

Christos Vaklavas ◽

...

Keyword(s):

Breast Cancer ◽

Monoclonal Antibody ◽

Phase Ii ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

Phase Ii Trial ◽

Death Receptor ◽

Death Receptor 5

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A phase I study of CS-1008 (humanized monoclonal antibody targeting death receptor 5 or DR5), administered weekly to patients with advanced solid tumors or lymphomas

Journal of Clinical Oncology ◽

10.1200/jco.2008.26.15_suppl.3537 ◽

2008 ◽

Vol 26 (15_suppl) ◽

pp. 3537-3537 ◽

Cited By ~ 18

Author(s):

M. N. Saleh ◽

I. Percent ◽

T. E. Wood ◽

J. Posey ◽

J. Shah ◽

...

Keyword(s):

Monoclonal Antibody ◽

Phase I ◽

Solid Tumors ◽

Phase I Study ◽

Death Receptor ◽

Advanced Solid Tumors ◽

Death Receptor 5 ◽

Humanized Monoclonal Antibody ◽

Antibody Targeting

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240 Molecular imaging of Death Receptor 5 (DR5) occupancy in-vivo by humanized monoclonal antibody CS-1008

European Journal of Cancer Supplements ◽

10.1016/s1359-6349(10)71945-5 ◽

2010 ◽

Vol 8 (7) ◽

pp. 78

Author(s):

A.M. Scott ◽

F.T. Lee ◽

G.C. Cartwright ◽

G.J. O'Keefe ◽

R.A. Beckman ◽

...

Keyword(s):

Monoclonal Antibody ◽

Molecular Imaging ◽

Death Receptor ◽

Death Receptor 5 ◽

Humanized Monoclonal Antibody

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Promoter structure and transcription initiation sites of the human death receptor 5/TRAIL-R2 gene1

FEBS Letters ◽

10.1016/s0014-5793(01)02947-7 ◽

2001 ◽

Vol 507 (3) ◽

pp. 381-385 ◽

Cited By ~ 88

Author(s):

Tatsushi Yoshida ◽

Ayaka Maeda ◽

Naoki Tani ◽

Toshiyuki Sakai

Keyword(s):

Transcription Initiation ◽

Death Receptor ◽

Death Receptor 5 ◽

Promoter Structure ◽

Human Death

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Apomab: An agonist monoclonal antibody directed against Death Receptor 5/TRAIL-Receptor 2 for use in the treatment of solid tumors

Expert Opinion on Biological Therapy ◽

10.1517/14712598.8.8.1167 ◽

2008 ◽

Vol 8 (8) ◽

pp. 1167-1176 ◽

Cited By ~ 37

Author(s):

D Ross Camidge

Keyword(s):

Monoclonal Antibody ◽

Solid Tumors ◽

Death Receptor ◽

Trail Receptor ◽

Death Receptor 5

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66 Tigatuzumab, a novel anti-human death receptor 5 antibody, shows synergistic efficacy against colon cancer in vitro and in vivo in combination with chemotherapy

European Journal of Cancer Supplements ◽

10.1016/s1359-6349(10)71771-7 ◽

2010 ◽

Vol 8 (7) ◽

pp. 29

Author(s):

A. Yada ◽

Y. Ogitani ◽

S. Ishida ◽

K. Ichikawa ◽

K. Fujiwara

Keyword(s):

Colon Cancer ◽

Death Receptor ◽

Death Receptor 5 ◽

Human Death

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Preparation and functional studies of hydroxyethyl chitosan nanoparticles loaded with anti-human death receptor 5 single-chain antibody

OncoTargets and Therapy ◽

10.2147/ott.s59872 ◽

2014 ◽

pp. 779 ◽

Cited By ~ 2

Author(s):

Jingjing Yang ◽

xiaoping huang ◽

bin liu ◽

xiaofeng cheng ◽

ping yin ◽

...

Keyword(s):

Chitosan Nanoparticles ◽

Death Receptor ◽

Death Receptor 5 ◽

Single Chain ◽

Single Chain Antibody ◽

Functional Studies ◽

Human Death

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