Department of Anatomy, Louisiana State University Medical Center, New Orleans, Louisiana 70112, U.S.A.
(Received 12 April 1977)
It is known that a functional interaction exists between the adrenal and ovarian systems, albeit complex and not well understood. Removal of progesterone derived from the adrenal gland disrupts the synchronous discharge of luteinizing hormone (LH) and consequently the events associated with reproduction (Mann, Korowitz & Barraclough, 1975). Adrenalectomy of female rats also delays the onset of puberty, disrupts the normal oestrous cycle and decreases the number of ova shed and the size of the litter (Ramaley, 1974). Previously we reported that unilaterally ovariectomized rats which had been bilaterally adrenalectomized for 30 days did not, after one oestrous cycle, show compensatory ovulation or ovarian hypertrophy; rats adrenalectomized and ovariectomized for 30 days did, however, display both phenomena (Peppler & Jacobs, 1976). While continuing these studies on adrenal gland–ovary interrelationships, we collected data which
Phase I Study with SV-BR-1 Breast Cancer Cell Line Vaccine and GMCSF: Clinical Experience in 14 Patients