Long-Term Preservation of Cardiac Structure and Function After Adeno-Associated Virus Serotype 9-Mediated Microdystrophin Gene Transfer inmdxMice

2012 ◽  
Vol 23 (6) ◽  
pp. 566-575 ◽  
Author(s):  
Stefanie Schinkel ◽  
Ralf Bauer ◽  
Raffi Bekeredjian ◽  
Rolf Stucka ◽  
Désirée Rutschow ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Structure And Function ◽  
Cardiac Structure ◽  
Adeno Associated Virus ◽  
Virus Serotype ◽  
Cardiac Structure And Function ◽  
And Function ◽  
Long Term Preservation

508: Cardiac structure and function in long-term pediatric heart transplant survivors

2007 ◽  
Vol 26 (2) ◽  
pp. S243
Author(s):  
A. Kulikowska ◽  
S.E. Boslaugh ◽  
S. Foerster ◽  
C.H. Gumbiner ◽  
K.E. Ward ◽  
...  
Keyword(s):  
Heart Transplant ◽  
Structure And Function ◽  
Cardiac Structure ◽  
Cardiac Structure And Function ◽  
And Function ◽  
Pediatric Heart Transplant

Abstract P138: Alterations in Cardiac Structure and Function in Young Adults Born Extremely Preterm: Impact of Neonatal Bronchopulmonary Dysplasia

Hypertension ◽  
2017 ◽  
Vol 70 (suppl_1) ◽  
Author(s):  
Muhammad Oneeb Rehman Mian ◽  
Jean-Luc Bigras ◽  
Rafael Fernandes ◽  
Mariane Bertagnolli ◽  
Li Feng Xie ◽  
...  
Keyword(s):  
Young Adults ◽  
Preterm Birth ◽  
Cardiac Remodeling ◽  
Structure And Function ◽  
Cardiac Structure ◽  
Lv Mass ◽  
Extremely Preterm ◽  
Cardiac Structure And Function ◽  
And Function

Objective: Studies support a causal association between preterm birth and increased risk of cardiovascular diseases. Increased left and right ventricular mass and impaired systolic and diastolic function has been reported in young adults born preterm. However, the impact of extreme preterm birth and prematurity-specific complications on adult cardiac structure and function has not been evaluated. We assessed cardiac structure and function in young adults born extremely preterm (EPT) versus term, and correlated long term cardiac remodeling with neonatal bronchopulmonary dysplasia (BPD). Methods: Eighty five EPT (gest. age = 27.1±1.4 weeks) were recruited along with term-born controls matched for age, sex and socioeconomic status. Birth and neonatal data (gestational age, birth weight, BPD indicated by O 2 requirements at 36 weeks postmenstrual age) was collected. Ambulatory blood pressure (Spacelabs) and echocardiographic measurements (Phillips) were taken. Comparisons were performed using ANOVA or T-test. Results: EPT presented with increased systolic (119±9 vs 116±8 mmHg, P<0.05) and diastolic (68±5 vs 66±6 mmHg, P<0.05) blood pressures. EPT exhibited reduced septal thickness (IVS, 6.8±0.8 vs 7.1±1.1 mm, P<0.05), left ventricular internal dimension (LVID, 46±4 vs 48±5 mm, P<0.05), LV end-diastolic (98±20 vs 106±24 ml, P<0.05) and end-systolic (36±9 vs 40±11 ml, P<0.01) volumes, right ventricular internal dimension (RVID, 22±3 vs 24±4 mm, P<0.05), and LV mass (104±27 vs 115±30 g, P<0.05), but similar LV mass and volume indexes. EPT exhibited increased LV myocardial performance index (0.41±0.04 vs 0.39±0.04, P<0.01), reduced mitral lateral e’ (17.6±2.8 vs 19.1±2.6 cm/s, P<0.01), mitral s’ (10.7±2.3 vs 11.6±2.3 cm/s, P<0.01), tricuspid E’ (15.8±2.7 vs 16.8±2.1 cm/s, P<0.05), and tricuspid S’ (13.1±2.0 vs 14.0±2.0 cm/s, P<0.01) waves, and a trend in reduced mitral E wave (81±14 vs 85±15 cm/s, P=0.09). EPT with neonatal BPD exhibited greater reduction in IVS (6.5±0.8 mm, P<0.05 vs terms), LVID (45±4 mm, P<0.05), LV Mass (98±22 g, P<0.05), and RVID (20±3 mm, P<0.01). Conclusions: EPT exhibit cardiac structural and functional alterations compared to term-born individuals. Neonatal BPD in EPT is a key contributor to long term cardiac remodeling.

scholarly journals GALECTIN-3, CARDIAC STRUCTURE AND FUNCTION, AND LONG-TERM MORTALITY IN PATIENTS WITH ACUTE HEART FAILURE

2010 ◽  
Vol 55 (10) ◽  
pp. A34.E329
Author(s):  
Ravi V. Shah ◽  
Annabel A. Chen-Tournoux ◽  
Michael H. Picard ◽  
Roland RJ van Kimmenade ◽  
James L. Januzzi
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Structure And Function ◽  
Cardiac Structure ◽  
Galectin 3 ◽  
Cardiac Structure And Function ◽  
And Function ◽  
Long Term Mortality

scholarly journals Fitness in Young Adulthood and Long-Term Cardiac Structure and Function

2017 ◽  
Vol 5 (5) ◽  
pp. 347-355 ◽  
Author(s):  
Ambarish Pandey ◽  
Norrina B. Allen ◽  
Colby Ayers ◽  
Jared P. Reis ◽  
Henrique T. Moreira ◽  
...  
Keyword(s):  
Young Adulthood ◽  
Structure And Function ◽  
Cardiac Structure ◽  
Cardiac Structure And Function ◽  
And Function
Sign in / Sign up

Export Citation Format

Share Document