Pharmacokinetic Modeling of Systemic Uptake Following Pulmonary Delivery of a Macromolecular Drug in a Sustained Release Formulation

1995 ◽  
Vol 8 (4) ◽  
pp. 317-329 ◽  
Author(s):  
ZVI TEITELBAUM ◽  
DAVID B. BENNETT
1985 ◽  
Vol 23 (11) ◽  
pp. 43-44

Piretanide is a loop diuretic recently marketed in a sustained-release formulation (Arelix - Hoechst) solely for the treatment of hypertension (rather than as a general diuretic). The manufacturer claims that piretanide has several advantages over the thiazides, including little or no effect on plasma potassium and magnesium, and no impairment of glucose tolerance.


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