In Vitro Activity of Tedizolid in Comparison with Other Oral and Intravenous Agents Against a Collection of Community-Acquired Methicillin-Resistant Staphylococcus aureus (2014–2015) in the United States

2019 ◽  
Vol 25 (6) ◽  
pp. 938-943 ◽  
Author(s):  
Michael A. Pfaller ◽  
Helio S. Sader ◽  
Paul R. Rhomberg ◽  
Robert K. Flamm ◽  
Rodrigo E. Mendes
Keyword(s):  
United States ◽  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
The United States ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Methicillin Resistant

scholarly journals Potency and Bactericidal Activity of Iclaprim against Recent Clinical Gram-Positive Isolates

2009 ◽  
Vol 53 (5) ◽  
pp. 2171-2175 ◽  
Author(s):  
Helio S. Sader ◽  
Thomas R. Fritsche ◽  
Ronald N. Jones
Keyword(s):  
United States ◽  
Staphylococcus Aureus ◽  
Enterococcus Faecalis ◽  
Bactericidal Activity ◽  
The United States ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Gram Positive ◽  
Methicillin Resistant

ABSTRACT The in vitro activity of iclaprim, a novel diaminopyrimidine derivative, was evaluated against 5,937 recent gram-positive clinical isolates collected in the United States and Europe. Iclaprim demonstrated potent activity against Staphylococcus aureus (including methicillin-resistant S. aureus [MRSA]), beta-hemolytic Streptococcus spp., and Enterococcus faecalis strains tested. In addition, iclaprim exhibited bactericidal activity against all S. aureus strains tested, including MRSA.

scholarly journals In vitro activity of minocycline combined with fosfomycin against clinical isolates of methicillin-resistant Staphylococcus aureus

2011 ◽  
Vol 64 (8) ◽  
pp. 559-562 ◽  
Author(s):  
Chunguang Sun ◽  
Matthew E Falagas ◽  
Rui Wang ◽  
Drosos E Karageorgopoulos ◽  
Xuhong Yu ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Vitro Activity ◽  
Clinical Isolates ◽  
In Vitro Activity ◽  
Methicillin Resistant

scholarly journals In Vitro 24-Hour Time-Kill Studies of Vancomycin and Linezolid in Combination versus Methicillin-Resistant Staphylococcus aureus

2009 ◽  
Vol 53 (10) ◽  
pp. 4495-4497 ◽  
Author(s):  
Shveta Rani Singh ◽  
Alfred E. Bacon ◽  
David C. Young ◽  
Kimberly A. Couch
Keyword(s):  
Staphylococcus Aureus ◽  
Conventional Therapy ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Antagonistic Activity ◽  
Vitro Activity ◽  
Synergistic Activity ◽  
In Vitro Activity ◽  
Methicillin Resistant ◽  
Time Kill

ABSTRACT Many clinicians are trying unique strategies, including vancomycin and linezolid in combination, for treatment of patients who do not respond to conventional therapy against methicillin (meticillin)-resistant Staphylococcus aureus. In our study, which illustrated in vitro activity only, no synergistic activity was seen when the two agents were combined. Conversely, antagonistic activity occurred in three of five strains when linezolid was added to vancomycin. Our results indicate that vancomycin and linezolid in combination should be avoided.

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