scholarly journals Multi-Modal Approach for Investigating Brain and Behavior Changes in an Animal Model of Traumatic Brain Injury

2013 ◽  
Vol 30 (11) ◽  
pp. 1007-1012 ◽  
Author(s):  
Meghan E. Heffernan ◽  
Wei Huang ◽  
Kenneth M. Sicard ◽  
Bernt T. Bratane ◽  
Elif M. Sikoglu ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Animal Model ◽  
Brain Injury ◽  
Behavior Changes ◽  
Modal Approach ◽  
Brain And Behavior ◽  
And Behavior

scholarly journals In vivo imaging of rapid deformation and strain in an animal model of traumatic brain injury

2006 ◽  
Vol 39 (6) ◽  
pp. 1086-1095 ◽  
Author(s):  
Philip V. Bayly ◽  
Erin E. Black ◽  
Rachel C. Pedersen ◽  
Elizabeth P. Leister ◽  
Guy M. Genin
Keyword(s):  
Traumatic Brain Injury ◽  
Animal Model ◽  
Brain Injury ◽  
In Vivo Imaging ◽  
Rapid Deformation

scholarly journals Experimental model of intracranial hypertension with continuous multiparametric monitoring in swine

2013 ◽  
Vol 71 (10) ◽  
pp. 802-806 ◽  
Author(s):  
Almir Ferreira de Andrade ◽  
Matheus Schmidt Soares ◽  
Gustavo Cartaxo Patriota ◽  
Alessandro Rodrigo Belon ◽  
Wellingson Silva Paiva ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Animal Model ◽  
Brain Injury ◽  
Intracranial Pressure ◽  
Intracranial Hypertension ◽  
Severe Traumatic Brain Injury ◽  
Transcranial Doppler ◽  
Porcine Model ◽  
Cerebral Oximetry ◽  
Suitable Animal Model

Objective Intracranial hypertension (IH) develops in approximately 50% of all patients with severe traumatic brain injury (TBI). Therefore, it is very important to identify a suitable animal model to study and understand the pathophysiology of refractory IH to develop effective treatments. Methods We describe a new experimental porcine model designed to simulate expansive brain hematoma causing IH. Under anesthesia, IH was simulated with a balloon insufflation. The IH variables were measured with intracranial pressure (ICP) parenchymal monitoring, epidural, cerebral oximetry, and transcranial Doppler (TCD). Results None of the animals died during the experiment. The ICP epidural showed a slower rise compared with parenchymal ICP. We found a correlation between ICP and cerebral oximetry. Conclusion The model described here seems useful to understand some of the pathophysiological characteristics of acute IH.

scholarly journals P4-161: REPETITIVE MILD TRAUMATIC BRAIN INJURY TRIGGERS AND EXACERBATES TAU PATHOLOGY AND BEHAVIOR

2019 ◽  
Vol 15 ◽  
pp. P1336-P1336
Author(s):  
George A. Edwards ◽  
Nicolas Mendez Dinamarca ◽  
Claudio Soto ◽  
Ines Moreno-Gonzalez
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Tau Pathology ◽  
And Behavior

scholarly journals Growth Hormone Alters Brain Morphometry, Connectivity, and Behavior in Subjects with Fatigue after Mild Traumatic Brain Injury

2020 ◽  
Vol 37 (8) ◽  
pp. 1052-1066 ◽  
Author(s):  
Traver Wright ◽  
Randall Urban ◽  
William Durham ◽  
E. Lichar Dillon ◽  
Kathleen M. Randolph ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Growth Hormone ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Brain Morphometry ◽  
And Behavior

scholarly journals Sensory sensitivity as a link between concussive traumatic brain injury and PTSD

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Ann N. Hoffman ◽  
Jamie Lam ◽  
David A. Hovda ◽  
Christopher C. Giza ◽  
Michael S. Fanselow
Keyword(s):  
Traumatic Brain Injury ◽  
Animal Model ◽  
Brain Injury ◽  
White Noise ◽  
Sensory Processing ◽  
Emotional Trauma ◽  
Sensory Sensitivity ◽  
Post Traumatic Stress ◽  
Medial Geniculate ◽  
Increased Activity

Abstract Traumatic brain injury (TBI) is one of the most common injuries to military personnel, a population often exposed to stressful stimuli and emotional trauma. Changes in sensory processing after TBI might contribute to TBI-post traumatic stress disorder (PTSD) comorbidity. Combining an animal model of TBI with an animal model of emotional trauma, we reveal an interaction between auditory sensitivity after TBI and fear conditioning where 75 dB white noise alone evokes a phonophobia-like phenotype and when paired with footshocks, fear is robustly enhanced. TBI reduced neuronal activity in the hippocampus but increased activity in the ipsilateral lateral amygdala (LA) when exposed to white noise. The white noise effect in LA was driven by increased activity in neurons projecting from ipsilateral auditory thalamus (medial geniculate nucleus). These data suggest that altered sensory processing within subcortical sensory-emotional circuitry after TBI results in neutral stimuli adopting aversive properties with a corresponding impact on facilitating trauma memories and may contribute to TBI-PTSD comorbidity.

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