Cerebral Blood Flow Predicts Recovery in Children with Persistent Post-Concussion Symptoms after Mild Traumatic Brain Injury

2021 ◽  
Author(s):  
Karen M. Barlow ◽  
Kartik Iyer ◽  
Tingting Yan ◽  
Alex Scurfield ◽  
Helen Carlson ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury

scholarly journals Cerebral Blood Flow and Its Connectivity Deficits in Mild Traumatic Brain Injury at the Acute Stage

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Fengfang Li ◽  
Liyan Lu ◽  
Song’an Shang ◽  
Huiyou Chen ◽  
Peng Wang ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Impairment ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Perfusion Magnetic Resonance Imaging ◽  
The Right

Objective. The influence of cognitive impairment after mild traumatic brain injury (mTBI) on cerebral vascular perfusion has been widely concerned, yet the resting-state cerebral blood flow (CBF) connectivity alterations based on arterial spin labeling (ASL) in mild traumatic brain injury (mTBI) remain unclear. This study investigated region CBF and CBF connectivity features in acute mTBI patients, as well as the associations between CBF changes and cognitive impairment. Materials and Methods. Forty-five acute mTBI patients and 42 health controls underwent pseudocontinuous arterial spin labeling (pCASL) perfusion magnetic resonance imaging (MRI). The alterations in regional CBF and relationship between the CBF changes and cognitive impairment were detected. The ASL-CBF connectivity of the brain regions with regional CBF significant differences was also compared between two groups. Neuropsychological tests covered seven cognitive domains. Associations between the CBF changes and cognitive impairment were further investigated. Results. Compared with the healthy controls, the acute mTBI patients exhibited increased CBF in the bilateral inferior temporal gyrus (ITG) and decreased CBF in the right middle frontal gyrus (MFG), the bilateral superior frontal gyrus (SFG), and the right cerebellum posterior lobe (CPL). In the mTBI patients, significant correlations were identified between the CBF changes and cognitive impairment. Importantly, the acute mTBI patients exhibited CBF disconnections between the right CPL and right fusiform gyrus (FG) as well as bilateral ITG, between the left SFG and left middle occipital gyrus (MOG), and between the right SFG and right FG as well as right parahippocampal gyrus. Conclusion. Our results suggest that acute mTBI patients exhibit both regional CBF abnormalities and CBF connectivity deficits, which may underlie the cognitive impairment of the acute mTBI patients.

scholarly journals P2-210: CEREBRAL BLOOD FLOW INVERSELY CORRELATES WITH AMYLOID PATHOLOGY AND NEUROINFLAMMATION AFTER REPETITIVE MILD TRAUMATIC BRAIN INJURY

2019 ◽  
Vol 15 ◽  
pp. P657-P658
Author(s):  
Sitara B. Sankar ◽  
Alyssa Pybus ◽  
Junho Yoo ◽  
Rowan Brothers ◽  
Amanda Liew ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Amyloid Pathology

scholarly journals Disruptions in Resting State Functional Connectivity and Cerebral Blood Flow in Mild Traumatic Brain Injury Patients

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0134019 ◽  
Author(s):  
Chandler Sours ◽  
Jiachen Zhuo ◽  
Steven Roys ◽  
Kathirkamanthan Shanmuganathan ◽  
Rao P. Gullapalli
Keyword(s):  
Traumatic Brain Injury ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Injury ◽  
Functional Connectivity ◽  
Mild Traumatic Brain Injury ◽  
Resting State ◽  
Resting State Functional Connectivity

scholarly journals Cerebral Blood Flow after Mild Traumatic Brain Injury: Associations between Symptoms and Post-Injury Perfusion

2018 ◽  
Vol 35 (2) ◽  
pp. 241-248 ◽  
Author(s):  
Jaclyn A. Stephens ◽  
Peiying Liu ◽  
Hanzhang Lu ◽  
Stacy J. Suskauer
Keyword(s):  
Traumatic Brain Injury ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Post Injury

scholarly journals Low cerebral blood flow is a non-invasive biomarker of neuroinflammation after repetitive mild traumatic brain injury

2019 ◽  
Vol 124 ◽  
pp. 544-554 ◽  
Author(s):  
Sitara B. Sankar ◽  
Alyssa F. Pybus ◽  
Amanda Liew ◽  
Bharat Sanders ◽  
Kajol J. Shah ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Non Invasive
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