scholarly journals A Systems Biology Interpretation of Array Comparative Genomic Hybridization (aCGH) Data through Phylogenetics

2016 ◽  
Vol 20 (3) ◽  
pp. 169-179 ◽  
Author(s):  
Ayman N. Abunimer ◽  
Jose Salazar ◽  
David P. Noursi ◽  
Mones S. Abu-Asab
Keyword(s):  
Systems Biology ◽  
Comparative Genomic Hybridization ◽  
Array Comparative Genomic Hybridization ◽  
Comparative Genomic ◽  
Genomic Hybridization ◽  
Acgh Data

scholarly journals Normalized, Segmented or Called aCGH Data?

2007 ◽  
Vol 3 ◽  
pp. 117693510700300 ◽  
Author(s):  
Wessel N. Van Wieringen ◽  
Mark A. Van De Wiel ◽  
Bauke Ylstra
Keyword(s):  
Comparative Genomic Hybridization ◽  
High Throughput ◽  
Array Comparative Genomic Hybridization ◽  
Comparative Genomic ◽  
Genomic Hybridization ◽  
Data Set ◽  
Acgh Data ◽  
Copy Numbers ◽  
Genome Wide ◽  
Processing Steps

Array comparative genomic hybridization (aCGH) is a high-throughput lab technique to measure genome-wide chromosomal copy numbers. Data from aCGH experiments require extensive pre-processing, which consists of three steps: normalization, segmentation and calling. Each of these pre-processing steps yields a different data set: normalized data, segmented data, and called data. Publications using aCGH base their findings on data from all stages of the pre-processing. Hence, there is no consensus on which should be used for further down-stream analysis. This consensus is however important for correct reporting of findings, and comparison of results from different studies. We discuss several issues that should be taken into account when deciding on which data are to be used. We express the believe that called data are best used, but would welcome opposing views.

A novel interstitial microdeletion of 7q22.1-7q22.3 detected by array comparative genomic hybridization

2011 ◽  
Vol 155 (12) ◽  
pp. 3128-3131 ◽  
Author(s):  
Zuhair N. Al-Hassnan ◽  
AlBandary Al-Bakheet ◽  
Nada Abu-Dheim ◽  
Banan Al-Younes ◽  
Dilek Colak ◽  
...  
Keyword(s):  
Comparative Genomic Hybridization ◽  
Array Comparative Genomic Hybridization ◽  
Comparative Genomic ◽  
Genomic Hybridization
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