Study of the therapeutic efficiency of transduced olfactory ensheathing cells in spinal cord cysts.

2021 ◽  
Author(s):  
Olga Vladislavovna Stepanova ◽  
Anastasia Voronova ◽  
Anastasiia Olegovna Sosnovtseva ◽  
Aleksei Anatolievich Stepanenko ◽  
Andrey Chadin ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Olfactory Ensheathing Cells ◽  
Therapeutic Efficiency ◽  
Ensheathing Cells ◽  
Spinal Cord Cysts

The Effect of Transplantation of Olfactory Ensheathing Cells on the Size of Posttraumatic Spinal Cord Cysts

2021 ◽  
Author(s):  
A. D. Voronova ◽  
O. V. Stepanova ◽  
A. V. Chadin ◽  
G. A. Fursa ◽  
E. K. Karsuntseva ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Olfactory Ensheathing Cells ◽  
Ensheathing Cells ◽  
Spinal Cord Cysts

scholarly journals Corrigendum to “Therapeutic Potential of Olfactory Ensheathing Cells and Mesenchymal Stem Cells in Spinal Cord Injuries”

2017 ◽  
Vol 2017 ◽  
pp. 1-1 ◽  
Author(s):  
Anna Zadroga ◽  
Katarzyna Jezierska-Woźniak ◽  
Joanna Czarzasta ◽  
Monika Barczewska ◽  
Joanna Wojtkiewicz ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Spinal Cord Injuries ◽  
Therapeutic Potential ◽  
Olfactory Ensheathing Cells ◽  
Ensheathing Cells

scholarly journals Delivery of chondroitinase by canine mucosal olfactory ensheathing cells alongside rehabilitation enhances recovery after spinal cord injury

2021 ◽  
pp. 113660
Author(s):  
Jon Prager ◽  
Daisuke Ito ◽  
Darren R. Carwardine ◽  
Prince Jiju ◽  
Divya M. Chari ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Olfactory Ensheathing Cells ◽  
Cord Injury ◽  
Ensheathing Cells

The effect of transplantation of the ensheathing cells on size of posttraumatic spinal cord cysts

2021 ◽  
pp. 18-23
Author(s):  
A. D. Voronova ◽  
◽  
O. V. Stepanova ◽  
A. V. Chadin ◽  
G. A. Fursa ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Ensheathing Cells ◽  
Spinal Cord Cysts

scholarly journals Protection of corticospinal tract neurons after dorsal spinal cord transection and engraftment of olfactory ensheathing cells

Glia ◽  
2006 ◽  
Vol 53 (4) ◽  
pp. 352-359 ◽  
Author(s):  
Masanori Sasaki ◽  
Bryan C. Hains ◽  
Karen L. Lankford ◽  
Stephen G. Waxman ◽  
Jeffery D. Kocsis
Keyword(s):  
Spinal Cord ◽  
Corticospinal Tract ◽  
Spinal Cord Transection ◽  
Olfactory Ensheathing Cells ◽  
Dorsal Spinal Cord ◽  
Ensheathing Cells ◽  
Dorsal Spinal

scholarly journals Comparison of intramedullary transplantation of olfactory ensheathing cell for patients with chronic complete spinal cord injury worldwide

2018 ◽  
Vol 1 (1) ◽  
pp. 146-151 ◽  
Author(s):  
Lin Chen ◽  
Yuqi Zhang ◽  
Xijing He ◽  
Saberi Hooshang
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Transplantation ◽  
Clinical Results ◽  
Postoperative Management ◽  
Olfactory Ensheathing Cells ◽  
Olfactory Ensheathing Cell ◽  
Advantages And Disadvantages ◽  
Cord Injury ◽  
Ensheathing Cells

Objectives:Traumatic spinal cord injury (tSCI) remains a major clinical challenge. Cell transplantation brings a glimmer of light, among them olfactory ensheathing cells (OECs) have shown some neurorestorative effect. Due to the results of each group lack basic consistency, many technical details are believed to affect the overall outcome. We compare the clinical outcome of intramedullary transplant of olfactory ensheathing cells for patients with spinal cord injury at multi-centers worldwide, and to explore the potential standardized transplantation that suits for the clinical requirements.Methods:Here, we used the Pubmed and CNKI databases to search online the literatures published in the last 20 years for the clinical studies/trials of OECs for chronic spinal cord injury in the representative clinical center. The results of these representative clinical treatment centers were searched and analyzed. The parameters which may affect the effect including the concentration of cells, the total number of cells, the choice of incision, the site of transplantation, the number of transplantation sites, the advantages and disadvantages of transplantation equipment, and postoperative management, were compared carefully to clarify its impact on the clinical results.Results:In these literatures, 2 Chinese centers, 1 Australian center and 1 European center were selected for intraspinal transplantation. The reason of different results may be due to the excessive injection times and/or the excessive total injection volume.Conclusions:Cell implant to the spinal cord parenchyma is effective for restoring neurological functions, but improper procedures may lead to ineffective results. Concise surgery appears to be more suitable for clinical application than ostensibly precise and complex injection procedures. Sufficient rehabilitation training is surely necessary for the integration of motor recovery after cell transplantation.

OBTAINING OF CELLULAR PREPARATIONS OF RAT AND HUMAN OLFACTORY MUCOSA AND THEIR INFLUENCE ON THE SIZE OF MODELED SPINAL CORD CYSTALS

2021 ◽  
Vol 1 (19) ◽  
pp. 75-77
Author(s):  
O.V. Stepanova ◽  
E.K. Karsuntseva ◽  
G.A. Fursa ◽  
A.V. Chadin ◽  
M.P. Valikhov ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Progenitor Cells ◽  
Olfactory Mucosa ◽  
Olfactory Ensheathing Cells ◽  
Complete Disappearance ◽  
Ensheathing Cells ◽  
Neural Stem Progenitor Cells ◽  
Human Olfactory Mucosa ◽  
Enriched Cultures

Enriched cultures of olfactory ensheathing cells and neural stem/progenitor cells were obtained according to our developed protocols from the olfactory mucosa of rat and human. It has been shown that only transplantation of human and rat olfactory ensheathing cells leads to a significant decrease in the size of cysts, as well as their complete disappearance in some animals.

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