Poly(Epsilon-Lysine) Dendrons Tethered with Phosphoserine Increase Mesenchymal Stem Cell Differentiation Potential of Calcium Phosphate Gels

2014 ◽  
pp. 140116074603009 ◽  
Author(s):  
Maria Grazia Raucci ◽  
Marco Antonio Alvarez-Perez ◽  
Steven Meikle ◽  
Luigi Ambrosio ◽  
Matteo Santin
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Calcium Phosphate ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Differentiation ◽  
Differentiation Potential ◽  
Mesenchymal Stem Cell Differentiation

scholarly journals Concise Review: The Regulatory Mechanism of Lysine Acetylation in Mesenchymal Stem Cell Differentiation

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Hong Yang ◽  
Yuexia Liu ◽  
Xuanchen Liu ◽  
Huihui Gu ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Mesenchymal Stem Cell ◽  
Bone Repair ◽  
Stem Cell Differentiation ◽  
Lysine Acetylation ◽  
Myocardial Repair ◽  
Differentiation Potential ◽  
Mesenchymal Stem Cell Differentiation ◽  
Multidirectional Differentiation

Nowadays, the use of MSCs has attracted considerable attention in the global science and technology field, with the self-renewal and multidirectional differentiation potential for diabetes, obesity treatment, bone repair, nerve repair, myocardial repair, and so on. Epigenetics plays an important role in the regulation of mesenchymal stem cell differentiation, which has become a research hotspot in the medical field. This review focuses on the role of lysine acetylation modification on the determination of MSC differentiation direction. During this progress, the recruitment of lysine acetyltransferases (KATs) and lysine deacetylases (KDACs) is the crux of transcriptional mechanisms in the dynamic regulation of key genes controlling MSC multidirectional differentiation.

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