Conservative Management of Pregnancy in Patients with Resistance to Thyroid Hormone Associated with Hashimoto's Thyroiditis

Thyroid ◽  
2014 ◽  
Vol 24 (11) ◽  
pp. 1656-1661 ◽  
Author(s):  
Corinne Jonas ◽  
Chantal Daumerie
Keyword(s):  
Thyroid Hormone ◽  
Conservative Management ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Resistance To Thyroid Hormone

Resistance to Thyroid Hormone in Hashimoto's Thyroiditis

2005 ◽  
Vol 352 (5) ◽  
pp. 517-518 ◽  
Author(s):  
Shuji Fukata ◽  
Gregory A. Brent ◽  
Masahiro Sugawara
Keyword(s):  
Thyroid Hormone ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Resistance To Thyroid Hormone

Challenging diagnosis of thyroid hormone resistance initially as Hashimoto’s thyroiditis

2019 ◽  
Vol 32 (2) ◽  
pp. 203-206 ◽  
Author(s):  
Tong Wooi Ch’ng ◽  
Vivian L. Chin
Keyword(s):  
Thyroid Hormone ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Heterozygous Mutation ◽  
Thyroid Peroxidase ◽  
Thyroid Function Tests ◽  
Resistance To Thyroid Hormone ◽  
Hyperactivity Disorder ◽  
Thyroid Peroxidase Antibody ◽  
High Index Of Suspicion

Abstract Background Resistance to thyroid hormone (RTH) commonly presents with goiter, attention deficit hyperactivity disorder (ADHD), short stature and tachycardia. However, due to its variable presentation with subtle clinical features, a third of the cases are mistreated, typically as hyperthyroidism. Case presentation A 15-year-old female with ADHD and oligomenorrhea was initially diagnosed as Hashimoto’s thyroiditis but found to have a rare heterozygous mutation in c803 C>G (p Ala 268 Gly) in the THRβ gene, confirming resistance to thyroid hormone. Conclusions Fluctuating thyroid function tests in addition to thyroid peroxidase antibody (TPO Ab) positivity complicated the diagnosis of RTH, initially diagnosed as Hashimoto’s thyroiditis. A high index of suspicion is needed to prevent misdiagnosis and mistreatment.

A Descriptive Study of Cytomorphological Grading of Hashimoto’s Thyroiditis and Its Association with Thyroid Hormone Profile in a Tertiary Care Center in Mandya, Karnataka

2021 ◽  
Vol 8 (29) ◽  
pp. 2644-2649
Author(s):  
Yakkar Muralidhar Bhat ◽  
Suma H.V ◽  
Shivakumar Sundaram Chettier ◽  
Maithri C.M.
Keyword(s):  
Thyroid Hormone ◽  
Hashimoto’S Thyroiditis ◽  
Care Center ◽  
Tertiary Care ◽  
Descriptive Study ◽  
Hashimoto's Thyroiditis ◽  
Endocrine Disorders ◽  
Thyroid Disorder ◽  
Thyroid Lesion ◽  
Hormone Profile

BACKGROUND Thyroid diseases are the most common endocrine disorders throughout the world. Hashimoto’s thyroiditis is an autoimmune thyroid disorder and it is the second most common thyroid lesion diagnosed on fine needle aspiration cytology (FNAC), only after goiter. FNAC is a quick, easy, safe, cost-effective and highly sensitive investigation for diagnosing Hashimoto’s thyroiditis. The cytomorphological grading of Hashimoto’s thyroiditis was 1st done by Bhatia et al. in 1912. The purpose of this study was to grade Hashimoto’s thyroiditis cytomorphologically according to lymphocytic infiltration and correlating it with thyroid hormone profile. METHODS This is a descriptive study of 87 cases which were diagnosed with Hashimoto’s thyroiditis from January 2019 to December 2019 at the Cytopathology, Department of Pathology, MIMS, Mandya. The slides were collected, reviewed and graded according to Bhatia et al.’s grading system. Thyroid hormone values were collected from the department of biochemistry. The association between cytological grades and thyroid hormone parameters such as T3, T4, TSH and antithyroid peroxidase (anti-TPO) antibody were evaluated. RESULTS In our study, female preponderance was noted. The age range in our study was 10 - 64 years and the majority of cases were in the age group of 21 - 40 years. Grade II was the most common cytological grade, followed by grade III. Based on thyroid function values, majority of the cases were hypothyroid, followed by euthyroid and remaining were hyperthyroid. Anti-TPO levels was raised in 80.6 %, most of them had hypothyroidism. CONCLUSIONS In our study, there was no statistical association between cytological grades and thyroid hormone status. KEYWORDS Hashimoto’s Thyroiditis, FNAC, Bhatia et al.’s Grading, Anti-TPO Antibodies, fT3, fT4, Immunoassay Analyzer

scholarly journals Effect of small doses of iodine on thyroid function in patients with Hashimoto's thyroiditis residing in an area of mild iodine deficiency

1998 ◽  
pp. 23-28 ◽  
Author(s):  
W Reinhardt ◽  
M Luster ◽  
KH Rudorff ◽  
C Heckmann ◽  
S Petrasch ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Iodine Deficiency ◽  
Subclinical Hypothyroidism ◽  
Hashimoto’S Thyroiditis ◽  
Thyroid Volume ◽  
Treated Group ◽  
Hashimoto's Thyroiditis ◽  
Control Group ◽  
Small Doses

OBJECTIVE: Several studies have suggested that iodine may influence thyroid hormone status, and perhaps antibody production, in patients with autoimmune thyroid disease. To date, studies have been carried out using large amounts of iodine. Therefore, we evaluated the effect of small doses of iodine on thyroid function and thyroid antibody levels in euthyroid patients with Hashimoto's thyroiditis who were living in an area of mild dietary iodine deficiency. METHODS: Forty patients who tested positive for anti-thyroid (TPO) antibodies or with a moderate to severe hypoechogenic pattern on ultrasound received 250 microg potassium iodide daily for 4 months (range 2-13 months). An additional 43 patients positive for TPO antibodies or with hypoechogenicity on ultrasound served as a control group. All patients were TBII negative. RESULTS: Seven patients in the iodine-treated group developed subclinical hypothyroidism and one patient became hypothyroid. Three of the seven who were subclinically hypothyroid became euthyroid again when iodine treatment was stopped. One patient developed hyperthyroidism with a concomitant increase in TBII titre to 17 U/l, but after iodine withdrawal this patient became euthyroid again. Only one patient in the control group developed subclinical hypothyroidism during the same time period. All nine patients who developed thyroid dysfunction had reduced echogenicity on ultrasound. Four of the eight patients who developed subclinical hypothyroidism had TSH concentrations greater than 3 mU/l. In 32 patients in the iodine-treated group and 42 in the control group, no significant changes in thyroid function, antibody titres or thyroid volume were observed. CONCLUSIONS: Small amounts of supplementary iodine (250 microg) cause slight but significant changes in thyroid hormone function in predisposed individuals.

scholarly journals Increased levels of serum interleukin-12 in Graves' disease

1999 ◽  
pp. 111-116 ◽  
Author(s):  
M Tamaru ◽  
B Matsuura ◽  
M Onji
Keyword(s):  
Thyroid Hormone ◽  
Hashimoto’S Thyroiditis ◽  
Normal Subjects ◽  
Free Thyroxine ◽  
Hashimoto's Thyroiditis ◽  
Interleukin 12 ◽  
Graves Disease ◽  
Prolonged Stimulation ◽  
Hyperthyroid State

We investigated serum total interleukin-12 (IL-12) levels in patients with Graves' disease and Hashimoto's thyroiditis. The serum IL-12 levels in Graves' disease were significantly increased in the hyperthyroid state, and were decreased during treatment with methimazole or propylthiouracil in accordance with the decline of free tri-iodothyronine (T(3)) levels, free thyroxine levels and thyroid-binding inhibiting immunoglobulin (TBII) levels. When T(3) was administered orally to normal subjects, serum IL-12 levels were slightly increased. These results suggest that IL-12 might be increased due to prolonged stimulation with thyroid hormone, and thyroid hormone by itself might be a self-perpetuating factor of Graves' disease via increased IL-12 production.

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