scholarly journals How Many Papillae in Conventional Papillary Carcinoma? A Clinical Evidence-Based Pathology Study of 235 Unifocal Encapsulated Papillary Thyroid Carcinomas, with Emphasis on the Diagnosis of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features

Thyroid ◽  
2019 ◽  
Vol 29 (12) ◽  
pp. 1792-1803 ◽  
Author(s):  
Bin Xu ◽  
Rene Serrette ◽  
R. Michael Tuttle ◽  
Bayan Alzumaili ◽  
Ian Ganly ◽  
...  
Keyword(s):  
Papillary Carcinoma ◽  
Clinical Evidence ◽  
Thyroid Neoplasm ◽  
Evidence Based ◽  
Papillary Thyroid ◽  
Thyroid Carcinomas ◽  
Nuclear Features

scholarly journals Study of variants of papillary carcinoma of Thyroid with a special emphasis on NIFTP (Non-invasive Follicular Thyroid Neoplasm with Papillary like nuclear features)

2021 ◽  
Vol 6 (3) ◽  
pp. 207-210
Author(s):  
G V R N Krishna kanth ◽  
N Nirmala Jyoti
Keyword(s):  
Papillary Carcinoma ◽  
Thyroid Neoplasms ◽  
Good Prognosis ◽  
Thyroid Neoplasm ◽  
Papillary Thyroid ◽  
Non Invasive ◽  
Observational Cohort ◽  
Retrospective Observational Cohort Study ◽  
Nuclear Features

Rapid advances have taken place in the classification of papillary thyroid neoplasms with reclassification and addition of new variants. One such change is the addition of a new entity called NIFTP (Non-invasive Follicular Thyroid Neoplasm with Papillary like nuclear features). So called recognising its non-malignant potential. The present study is a retrospective observational cohort study on thyroidectomy specimens collected between Jan 2018 to June 2021 focussing on variants of papillary carcinoma with special emphasis on recognising NIFTP – which has got good prognosis and is considered non-malignant. Out of the 40 cases of papillary neoplasms 36 were PTC and 4 were NIFTP. Among the PTC cases 27 were classic PTC, 4 were FVPTC (Follicular Variant of Papillary Thyroid Carcinoma) 3 were papillary microcarcinoma, 1 was Warthin like Variant of PTC and 1 was Encapsulated PTC. The Study concludes that special vigilance is required in strictly adhering to the criteria proposed by new 2017 WHO classification of Papillary tumours. Recognising NIFTP as it is a non-malignant entity should be given due importance.

scholarly journals Cytohistological Concordance of Papillary Carcinoma of Thyroid and Its Variants

2021 ◽  
Vol 8 (04) ◽  
pp. 213-218
Author(s):  
Nameera Saleem ◽  
Naval Kishore Bajaj ◽  
Ezhil Arasi Nagamuthu
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Carcinoma ◽  
Fine Needle Aspiration ◽  
Histopathological Examination ◽  
Correct Diagnosis ◽  
Needle Aspiration ◽  
Papillary Thyroid ◽  
Fine Needle ◽  
Nuclear Features

BACKGROUND Papillary thyroid carcinoma is the most common malignancy of the thyroid gland. Fine Needle Aspiration Cytology (FNAC) is a rapid, safe and economic procedure, and has a sensitivity approaching of 93.5 % and specificity close to 90 % for diagnosing papillary thyroid carcinomas. This study aims at correlating the cytological and histological diagnosis to arrive at the rate of concordance and discordance, identify variants of papillary thyroid carcinoma (PTC) on cytology and discuss the cytological mimics of PTC. METHODS Data from cases was collected over a period of three years (2015 - 2018). A descriptive study was done. Cases from Osmania General Hospital representing histologically proven cases of papillary carcinoma thyroid along with their corresponding cytological findings were analysed. Cytosmears were obtained from fine needle aspiration of thyroid lesions using a 26-gauge needle, stained with haematoxylin and eosin (H&E). Thyroidectomy specimens were fixed in 10 % buffered formalin, grossed and paraffin embedded. After processing, sections obtained by microtomy were stained with H & E for histopathologic evaluation. RESULTS The institute received a total of 258 thyroid specimens for histopathology and 686 cases for thyroid FNAC over a period of three years. This study includes 70 cases which had both cytology and histopathology correlation at our institution. 65 cases were diagnosed as PTC on histopathology and correct diagnosis was made on cytology with 73.8 % concordance (48 / 65 cases) and discordance was seen in 26.1 % (17 / 65 cases). 5 cases were misdiagnosed on cytology as PTC, and on histopathological examination were diagnosed as non-PTC. CONCLUSIONS Fine needle aspiration shows variable accuracy for PTC, ranging from 65 % to 90 %. The architectural arrangement of cells in papillary fragments and presence of nuclear features in majority of cells is diagnostic of the conventional variant of PTC. The other variants however, pose a diagnostic dilemma on account of their architectural variation, altered cytomorphology and the scant presence of nuclear features. An increase in the awareness of cytomorphology of variants and also of the mimics of PTC helps improve the diagnostic accuracy on FNAC. KEYWORDS Papillary Thyroid Carcinoma, Variants of PTC, Cytohistopathological Correlation

scholarly journals Effect of Implementing the New Diagnostic Criteria for Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features in King Abdulaziz University Hospital

2016 ◽  
Vol 23 (3) ◽  
pp. 31-37
Author(s):  
Fatimah A. Alturkistani ◽  
Murad A. Alturkustani
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Diagnostic Criteria ◽  
University Hospital ◽  
Thyroid Neoplasm ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
King Abdulaziz University ◽  
Nuclear Features

Pathological diagnosis of follicular variant of papillary thyroid carcinoma has high inter and intra-observer variability among expert pathologists, aff ecting prognosis and management of the disease. A recent study applying strict diagnostic criteria and long-term follow up confi rmed the indolent behavior of a subtype of these tumors. They recommended a nomenclature change to noninvasive follicular thyroid neoplasm with papillary-like nuclear features, refl ecting the low risk of adverse outcomes. We searched the pathology archives of King Abdulaziz University Hospital from 2002-2016 for all cases diagnosed with “follicular variant of papillary thyroid carcinoma”. Clinical data, and imaging fi ndings were retrospectively reviewed. Available pathologyslides were reviewed using the proposed inclusion and exclusion diagnostic criteria. We confi rmed the diagnostic reproducibility of the suggested criteria. Ten out of 37 cases met the diagnostic criteria. Eightadditional patients could have had their diagnosis modifi ed if sufficient tissue samples were available. Follow up data confi rmed the indolent behavior in these cases with no recurrence or adverse outcome. We concluded that application of the new diagnostic criteria for this subtype is reasonable and has major ramifi cations for the diagnosis and management as this will spare unnecessary thyroidectomies, radioactive iodine therapy, and their complications.

Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features in Children: An Institutional Experience and Literature Review

2019 ◽  
Vol 23 (2) ◽  
pp. 121-126 ◽  
Author(s):  
Huiying Wang ◽  
Hernan Correa ◽  
Melinda Sanders ◽  
Wallace W Neblett ◽  
Jiancong Liang
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Thyroid Neoplasm ◽  
Molecular Signature ◽  
Papillary Thyroid ◽  
Total N ◽  
Recent Recommendation ◽  
Institutional Experience ◽  
Nuclear Features

Background Papillary thyroid carcinoma (PTC) in children has a distinctive set of clinicopathologic features and molecular signature compared to their adult counterparts. The recent recommendation to reclassify encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) without invasion as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is based on evidence derived almost exclusively from studies in adults. Clinicopathologic studies restricted to pediatric NIFTP are limited. Methods We retrospectively analyzed all pediatric PTC and NIFTP diagnosed and treated in our institution from 1999 to 2016 (n = 31). Results Using recently published consensus diagnostic criteria, we identified 3 NIFTP and 2 infiltrative follicular variants of papillary thyroid carcinoma (FVPTC) among 31 cases. Two of the NIFTP cases were initially diagnosed as EFVPTC. All 3 patients with NIFTP had unifocal tumors of lower American Joint Committee on Cancer (AJCC) classification (T2 or lower) and were free of lymph node or distant metastasis. Total (n = 1) or completion (n = 2) thyroidectomy was performed in all cases, and only 1 NIFTP patient received subsequent radioablative therapy. No residual or recurrent disease has been observed during follow-up (15–138 months) in patients with NIFTP. Conclusions Our experience with NIFTP in children is similar to outcomes reported in adult studies, suggesting that pediatric NIFTP behave indolently as evidenced by the absence of local recurrence in our cohort.

Papillary carcinoma in a thyroglossal duct remnant with normal thyroid gland

1993 ◽  
Vol 107 (12) ◽  
pp. 1174-1176 ◽  
Author(s):  
Kadriye Yildiz ◽  
Haydar Köksal ◽  
Yavuz Özoran ◽  
Hayrettin Muhtar ◽  
Münir Telatar
Keyword(s):  
Thyroid Gland ◽  
Papillary Carcinoma ◽  
Papillary Thyroid ◽  
Thyroglossal Duct ◽  
Normal Thyroid ◽  
Thyroid Carcinomas ◽  
First Report ◽  
Thyroglossal Duct Remnant

Carcinoma in the thyroglossal duct remnant is relatively uncommon. Since the first report by Uchermann (1915), more than 150 cases of carcinoma have been reported, and the majority have been papillary thyroid carcinomas (Li Volsi etal., 1974; McNicol etal., 1988). In this report, we present a case of papillary carcinoma in the thyroglossal duct with a normal thyroid gland

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