scholarly journals Liothyronine and Desiccated Thyroid Extract in the Treatment of Hypothyroidism

Thyroid ◽  
2020 ◽  
Vol 30 (10) ◽  
pp. 1399-1413 ◽  
Author(s):  
Thaer Idrees ◽  
Scott Palmer ◽  
Rui M.B. Maciel ◽  
Antonio C. Bianco
Keyword(s):  
Thyroid Extract

THE RELATIVE DISTRIBUTION OF THYROXINE, TRIIODOTHYRONINE AND 3,3′,5′-(REVERSE)-TRIIODOTHYRONINE IN VARIOUS FRACTIONS OF THYROGLOBULIN

1978 ◽  
Vol 88 (2) ◽  
pp. 298-305 ◽  
Author(s):  
Peter Laurberg
Keyword(s):  
Ionic Strength ◽  
Guinea Pig ◽  
Sucrose Gradient ◽  
Deae Cellulose ◽  
High Ionic Strength ◽  
Relative Distribution ◽  
Thyroid Extract ◽  
Reverse Triiodothyronine ◽  
Thyroid Secretion ◽  
Stable Iodine

ABSTRACT Thyroglobulin fractions rich and poor in new thyroglobulin were separated by means of DEAE-cellulose chromatography of dog thyroid extracts and by zonal ultracentrifugation in a sucrose gradient of guinea pig thyroid extract incubated at low temperature. The distribution of thyroxine, triiodothyronine and 3,3′,5′-(reverse)-triiodothyronine in hydrolysates of the different fractions was estimated by radioimmunoassays. Following DEAE-cellulose chromatography there was a small but statistically significant increase in the T4/T3 ratio in thyroglobulin fractions eluted at high ionic strength - that is fractions relatively rich in stable iodine but poor in fresh thyroglobulin. There were no differences in the T4/rT3 ratios between the different fractions. The ratios between iodothyronines were almost identical in the various thyroglobulin fractions following zonal ultracentrifugation in a sucrose gradient of cold treated guinea pig thyroid extract. These findings lend no support to the possibility that a relatively high content of triiodothyronines in freshly synthesized thyroglobulin modulates the thyroid secretion towards a preferential secretion of triiodothyronine and 3,3′,5′-(reverse)-triiodothyronine at the expense of the secretion of thyroxine.

EFFECT OF EXPERIMENTALLY INDUCED THYROIDITIS ON BIOSYNTHESIS OF THYROXINE IN RATS

1969 ◽  
Vol 62 (1) ◽  
pp. 11-20 ◽  
Author(s):  
Colum A. Gorman ◽  
James W. Anderson ◽  
Eunice V. Flock ◽  
Charles A. Owen ◽  
Khalil G. Wakim
Keyword(s):  
Intravenous Administration ◽  
Hashimoto's Thyroiditis ◽  
Sprague Dawley ◽  
Thyroid Extract ◽  
Histologic Appearance ◽  
Gland Weight ◽  
Sprague Dawley Rats ◽  
Thyroid Glands ◽  
And Control ◽  
Experimentally Induced

ABSTRACT Thyroiditis was induced in Sprague-Dawley rats by repeated immunization with thyroid extract and Freund's adjuvant. Immunized and control animals were killed at intervals up to 6 hours after intravenous administration of 131I as iodide at 5, 8 and 10 weeks after the first injection. Radioiodinated compounds in the thyroid glands were identified chromatographically. Evidence of moderate thyroiditis was present (histologic appearance, gland weight, and protein-bound iodine-butanol-extractable iodine difference) but the rate of incorporation of radioiodide into thyroxine, the percentage of radioactivity in the gland as iodide, and the MIT/DIT ratio were not significantly different in immunized and control animals. The MIT/DIT ratio was found to vary with time after 131I administration in both immunized and control animals. These studies did not uncover a defect in organification of iodide in experimental thyroiditis similar to that described by others in humans with Hashimoto's thyroiditis.

A Report on some Recent Cases of "Malignant" Indian Syphilis Treated with Thyroid Extract

BMJ ◽  
1894 ◽  
Vol 2 (1749) ◽  
pp. 12-12 ◽  
Author(s):  
J. D. Menzies
Keyword(s):  
Thyroid Extract

AN INVESTIGATION OF THE PATHOGENESIS OF HASHIMOTO'S DISEASE BY THYROID TISSUE CULTURE

1960 ◽  
Vol 20 (2) ◽  
pp. 83-NP ◽  
Author(s):  
W. J. IRVINE
Keyword(s):  
Tissue Culture ◽  
Alternative Hypothesis ◽  
Thyroid Tissue ◽  
Human Thyroid ◽  
Rabbit Serum ◽  
Thyroid Cell ◽  
Thyroid Extract ◽  
Thyroid Cells ◽  
Hashimoto’S Disease ◽  
Hashimoto's Disease

SUMMARY Human thyroid cells were grown in tissue culture in media containing normal human serum, Hashimoto serum, and rabbit sera containing antibodies to purified human thyroglobulin and to crude thyroid extract, respectively. The thyroid cells grew equally well in all media, with the exception of the rabbit serum containing antibodies to crude thyroid extract. Intact thyroid cells obtained from tissue culture failed to fix Hashimoto antibodies in the presence of complement, whereas the constituents of disrupted thyroid cells gave a strongly positive complement-fixation test with Hashimoto serum. It is therefore suggested that the intact thyroid cell is impermeable to complement-fixing Hashimoto antibody. The evidence afforded by the present work adds further weight to the belief that Hashimoto's disease may not be due to a simple auto-immunizing process consequent upon the interaction of thyroid antigen and the known circulating auto-antibodies. Evidence in support of an alternative hypothesis involving 'cell-bound' antibodies with disruption of the follicular basement membrane is discussed.

THYROID EXTRACT AND ITS EFFECT ON OVULATION AND MENSTRUATION

1953 ◽  
Vol 46 (9) ◽  
pp. 898-905 ◽  
Author(s):  
W O Johnson ◽  
J T Bradbury
Keyword(s):  
Thyroid Extract

An Investigation as to the Therapeutic Value of Thyroid Feeding in Mental Diseases

1912 ◽  
Vol 58 (242) ◽  
pp. 424-447
Author(s):  
Richard Eager
Keyword(s):  
Mental Disorder ◽  
State Hospital ◽  
Thyroid Extract ◽  
Valuable Addition ◽  
Therapeutic Value ◽  
Mental Diseases ◽  
History Of

The history of the use of thyroid extract in insanity dates back to the year 1893, when McPherson (1), of Larbert Asylum, reported a case of myxódematous insanity which recovered from both the myxódema and the mental disorder under its use. Its use in cretinism has also met with much success. My investigations, however, are confined to its use in mental conditions not associated with myxódema or cretinism. In 1894 McClaughey (2), of the District Asylum, Maryborough, reported two cases as improved, and in 1894–5 McPhail and Brace's results (3) and observations of treatment were published in detail. The publication of their results and their belief that “in thyroid feeding we possess a valuable addition to our armamentarium in the treatment of certain cases of insanity” incited many other alienists to test its efficacy. Besides Clarke, Brush and Burges in America must be mentioned Mabon and Babcock (4), who give a review of the results obtained in 1032 collected cases of insanity from twenty-four different observers, and who show that 23·9 per cent. recovered and 29·4 per cent. were improved. They also report on a further use of thyroid on sixty-one cases at the St. Lawrence State Hospital.

Thyroid Extract for the Itching of Jaundice

BMJ ◽  
1937 ◽  
Vol 1 (3970) ◽  
pp. 301-301
Author(s):  
P. N. Bardhan
Keyword(s):  
Thyroid Extract

A STUDY OF THE MELANOPHORE-CONCENTRATING EFFECT OF MAMMALIAN THYROID EXTRACT IN RAINBOW TROUT*

Endocrinology ◽  
1951 ◽  
Vol 48 (6) ◽  
pp. 658-668 ◽  
Author(s):  
O. H. ROBERTSON
Keyword(s):  
Rainbow Trout ◽  
Thyroid Extract

THE VALUE OF THYROID EXTRACT.

JAMA ◽  
1899 ◽  
Vol XXXII (5) ◽  
pp. 251
Keyword(s):  
Thyroid Extract

scholarly journals Response to Letter to the Editor from Steen Joop Bonnema: (Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism)”

2021 ◽  
Author(s):  
Mohamed K M Shakir ◽  
Daniel I Brooks ◽  
Elizabeth A McAninch ◽  
Tatiana De Lourdes Fonseca ◽  
Vinh Q Mai ◽  
...  
Keyword(s):  
Comparative Effectiveness ◽  
Thyroid Extract ◽  
Letter To The Editor
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