Selpercatinib-Enhanced Radioiodine Uptake in RET-Rearranged Thyroid Cancer

Thyroid ◽  
2021 ◽  
Author(s):  
Lionel Groussin ◽  
Laura Bessiene ◽  
Jennifer Arrondeau ◽  
Simon Garinet ◽  
Beatrix Cochand-Priollet ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Radioiodine Uptake

Enhancing radioiodine uptake in thyroid cancer

2013 ◽  
Author(s):  
V E Smith
Keyword(s):  
Thyroid Cancer ◽  
Radioiodine Uptake

scholarly journals Expression and function of the novel proto-oncogene PBF in thyroid cancer: a new target for augmenting radioiodine uptake

2011 ◽  
Vol 210 (2) ◽  
pp. 157-163 ◽  
Author(s):  
Vicki E Smith ◽  
Jayne A Franklyn ◽  
Christopher J McCabe
Keyword(s):  
Thyroid Cancer ◽  
Current Data ◽  
Subcellular Localisation ◽  
Sodium Iodide Symporter ◽  
Iodide Uptake ◽  
Radioiodine Uptake ◽  
Novel Target ◽  
And Function

Pituitary tumor-transforming gene (PTTG)-binding factor (PBF; PTTG1IP) was initially identified through its interaction with the human securin, PTTG. Like PTTG, PBF is upregulated in multiple endocrine tumours including thyroid cancer. PBF is believed to induce the translocation of PTTG into the cell nucleus where it can drive tumourigenesis via a number of different mechanisms. However, an independent transforming ability has been demonstrated both in vitro and in vivo, suggesting that PBF is itself a proto-oncogene. Studied in only a limited number of publications to date, PBF is emerging as a protein with a growing repertoire of roles. Recent data suggest that PBF possesses a complex multifunctionality in an increasing number of tumour settings. For example, PBF is upregulated by oestrogen and mediates oestrogen-stimulated cell invasion in breast cancer cells. In addition to a possible role in the induction of thyroid tumourigenesis, PBF overexpression in thyroid cancers inhibits iodide uptake. PBF has been shown to repress sodium iodide symporter (NIS) activity by transcriptional regulation of NIS expression through the human NIS upstream enhancer and further inhibits iodide uptake via a post-translational mechanism of NIS governing subcellular localisation. This review discusses the current data describing PBF expression and function in thyroid cancer and highlights PBF as a novel target for improving radioiodine uptake and thus prognosis in thyroid cancer.

FDG PET Performed at Thyroid Remnant Ablation Has a Higher Predictive Value for Long-Term Survival of High-Risk Patients With Well-Differentiated Thyroid Cancer Than Radioiodine Uptake

2015 ◽  
Vol 40 (5) ◽  
pp. 378-383 ◽  
Author(s):  
Florian C. Gaertner ◽  
Shozo Okamoto ◽  
Tohru Shiga ◽  
Yoichi M. Ito ◽  
Yuko Uchiyama ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
High Risk ◽  
Differentiated Thyroid Cancer ◽  
Thyroid Remnant ◽  
Term Survival ◽  
Radioiodine Uptake ◽  
Remnant Ablation ◽  
Risk Patients ◽  
Well Differentiated

Electroporation: a novel approach to enhance the radioiodine uptake in a human thyroid cancer cell line

2003 ◽  
Vol 59 (5-6) ◽  
pp. 305-310 ◽  
Author(s):  
R. Gopal ◽  
A.A. Narkar ◽  
K.P. Mishra ◽  
A.M. Samuel ◽  
N. Nair
Keyword(s):  
Thyroid Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Human Thyroid ◽  
Thyroid Cancer Cell ◽  
Radioiodine Uptake ◽  
Thyroid Cancer Cell Line ◽  
Novel Approach

Selumetinib Treatment Increases Radioiodine Uptake in Thyroid Cancer Lung Metastases

2017 ◽  
Vol 41 (5) ◽  
pp. S41
Author(s):  
Kirstie Lithgow ◽  
Peter Grundy ◽  
Sana Ghaznavi ◽  
Chris Symonds ◽  
Douglas Van Nostrand ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lung Metastases ◽  
Radioiodine Uptake

Radioiodine Uptake in Normal Female Breasts and Liver of a Patient with Differentiated Thyroid Cancer Imaged by Whole Body Scanning

Thyroid ◽  
2003 ◽  
Vol 13 (5) ◽  
pp. 511-511 ◽  
Author(s):  
P. Perros ◽  
U. K. Mallick ◽  
J. D. Fenwick
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Whole Body ◽  
Normal Female ◽  
Radioiodine Uptake ◽  
Body Scanning
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