scholarly journals Heterophilic cell–cell adhesion of atypical cadherins Fat and Dachsous regulate epithelial cell size dynamics during Drosophila thorax morphogenesis

2020 ◽  
Vol 31 (7) ◽  
pp. 546-560
Author(s):  
Amit Kumar ◽  
Mohd Suhail Rizvi ◽  
Thamarailingam Athilingam ◽  
Saurabh Singh Parihar ◽  
Pradip Sinha
Keyword(s):  
Cell Adhesion ◽  
Epithelial Cell ◽  
Mathematical Simulation ◽  
Cell Size ◽  
Epithelial Morphogenesis ◽  
Dynamic Changes ◽  
Size Regulation ◽  
Genetic Techniques ◽  
Cell Cell

Epithelial morphogenesis is marked by dynamic changes in cell sizes until the final adult organ is formed. Using a combination of quantitative, mathematical simulation and genetic techniques, this paper reveals a novel mechanism of epithelial cell size regulation based on heterophilic cell–cell adhesion between two atypical cadherins, Ft and Ds.

scholarly journals Myosin VI plays a role in cell–cell adhesion during epithelial morphogenesis

2004 ◽  
Vol 121 (11) ◽  
pp. 1335-1351 ◽  
Author(s):  
Hadas Millo ◽  
Kevin Leaper ◽  
Vasiliki Lazou ◽  
Mary Bownes
Keyword(s):  
Cell Adhesion ◽  
Epithelial Morphogenesis ◽  
Myosin Vi ◽  
Cell Cell

scholarly journals A molecular mechanism directly linking E-cadherin adhesion to initiation of epithelial cell surface polarity

2007 ◽  
Vol 178 (2) ◽  
pp. 323-335 ◽  
Author(s):  
Lene N. Nejsum ◽  
W. James Nelson
Keyword(s):  
Cell Adhesion ◽  
Epithelial Cell ◽  
Cell Surface ◽  
Basolateral Membrane ◽  
Surface Polarity ◽  
Cell Contacts ◽  
Protein Receptors ◽  
Epithelial Cell Surface ◽  
E Cadherin ◽  
Cell Cell

Mechanisms involved in maintaining plasma membrane domains in fully polarized epithelial cells are known, but when and how directed protein sorting and trafficking occur to initiate cell surface polarity are not. We tested whether establishment of the basolateral membrane domain and E-cadherin–mediated epithelial cell–cell adhesion are mechanistically linked. We show that the basolateral membrane aquaporin (AQP)-3, but not the equivalent apical membrane AQP5, is delivered in post-Golgi structures directly to forming cell–cell contacts where it co-accumulates precisely with E-cadherin. Functional disruption of individual components of a putative lateral targeting patch (e.g., microtubules, the exocyst, and soluble N-ethylmaleimide–sensitive factor attachment protein receptors) did not inhibit cell–cell adhesion or colocalization of the other components with E-cadherin, but each blocked AQP3 delivery to forming cell–cell contacts. Thus, components of the lateral targeting patch localize independently of each other to cell–cell contacts but collectively function as a holocomplex to specify basolateral vesicle delivery to nascent cell–cell contacts and immediately initiate cell surface polarity.

scholarly journals Cell–cell adhesion interface: orthogonal and parallel forces from contraction, protrusion, and retraction

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 1544 ◽  
Author(s):  
Vivian W. Tang
Keyword(s):  
Cell Adhesion ◽  
Epithelial Cell ◽  
Mechanical Force ◽  
Cell Behavior ◽  
Cellular Forces ◽  
The Relationship ◽  
Cell Interface ◽  
Lateral Cell ◽  
Strength Of Adhesion ◽  
Cell Cell

The epithelial lateral membrane plays a central role in the integration of intercellular signals and, by doing so, is a principal determinant in the emerging properties of epithelial tissues. Mechanical force, when applied to the lateral cell–cell interface, can modulate the strength of adhesion and influence intercellular dynamics. Yet the relationship between mechanical force and epithelial cell behavior is complex and not completely understood. This commentary aims to provide an investigative look at the usage of cellular forces at the epithelial cell–cell adhesion interface.

scholarly journals The Evolutionary Origin of Epithelial Cell–Cell Adhesion Mechanisms

2013 ◽  
pp. 267-311 ◽  
Author(s):  
Phillip W. Miller ◽  
Donald N. Clarke ◽  
William I. Weis ◽  
Christopher J. Lowe ◽  
W. James Nelson
Keyword(s):  
Cell Adhesion ◽  
Epithelial Cell ◽  
Evolutionary Origin ◽  
Cell Cell
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