Serum Lipids, Dietary Factors and Ischemic Heart Disease

1967 ◽  
Vol 20 (5) ◽  
pp. 462-474 ◽  
Author(s):  
S. L. MALHOTRA
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Serum Lipids ◽  
Dietary Factors ◽  
Ischemic Heart

Serum Lipids Profiling Perturbances in Patients with Ischemic Heart Disease and Ischemic Cardiomyopathy

2020 ◽  
Author(s):  
Lin Yang ◽  
Liang Wang ◽  
Yangyang Deng ◽  
Lizhe Sun ◽  
Bowen Low ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Ischemic Cardiomyopathy ◽  
Serum Lipids ◽  
Ischemic Heart ◽  
Negative Ion ◽  
Serum Samples ◽  
Cross Sectional ◽  
Negative Ion Mode ◽  
Positive Ion

Abstract Background: Ischemic heart disease (IHD) is a common cardiovascular disorder associated with inadequate blood supply to the myocardium. Chronic coronary ischemia leads to ischemic cardiomyopathy (ICM). Despite their rising prevalence and morbidity, few studies have discussed the lipids alterations in these patients. Methods: In this cross-sectional study, we analyzed serum lipids profile in IHD and ICM patients using a lipidomics approach. Consecutive consenting patients admitted to the hospital for IHD and ICM were enrolled. Serum samples were obtained after overnight fasting. Non-targeted metabolomics was applied to demonstrate lipids metabolic profile in control, IHD and ICM patients. Results: A total of 63 and 62 lipids were detected in negative and positive ion mode respectively. Among them, 16:0 Lyso PI, 18:1 Lyso PI in negative ion mode, and 19:0 Lyso PC, 12:0 SM d18:1/12:0, 15:0 Lyso PC, 17:0 PC, 18:1-18:0 PC in positive ion mode were significantly altered both in IHD and ICM as compared to control. 13:0 Lyso PI, 18:0 Lyso PI, 16:0 PE, 14:0 PC DMPC, 16:0 ceramide, 18:0 ceramide in negative ion mode, and 17:0 PE, 19:0 PC, 14:0 Lyso PC, 20:0 Lyso PC, 18:0 PC DSPC, 18:0-22:6 PC in positive ion mode were significantly altered only in ICM as compared to IHD and control. Conclusion: Using non-targeted lipidomics profiling, we have successfully identified a group of circulating lipids that were significantly altered in IHD and ICM. The lipids metabolic signatures shed light on potential new biomarkers and therapeutics for preventing and treating ICM.

scholarly journals Serum lipids profiling perturbances in patients with ischemic heart disease and ischemic cardiomyopathy

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Lin Yang ◽  
Liang Wang ◽  
Yangyang Deng ◽  
Lizhe Sun ◽  
Bowen Lou ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Ischemic Cardiomyopathy ◽  
Serum Lipids ◽  
Ischemic Heart

scholarly journals Effects of copper and zinc on ischemic heart disease and myocardial infarction: a Mendelian randomization study

2018 ◽  
Vol 108 (2) ◽  
pp. 237-242 ◽  
Author(s):  
Hanish P Kodali ◽  
Brian T Pavilonis ◽  
C Mary Schooling
Keyword(s):  
Sensitivity Analysis ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Genome Wide Association Study ◽  
Mendelian Randomization ◽  
Dietary Factors ◽  
Ischemic Heart ◽  
P Value ◽  
Copper And Zinc ◽  
A Genome

ABSTRACTBackgroundDespite great progress in prevention and control, ischemic heart disease (IHD) remains a leading cause of global morbidity and mortality. Diet plays a key role in IHD, but a comprehensive delineation of the role of dietary factors in IHD is not yet quite complete.ObjectiveThe aim of this study was to test the long-standing hypothesis that copper is protective and zinc harmful in IHD.DesignWe used separate-sample instrumental variable analysis with genetic instruments (Mendelian randomization). We obtained single nucleotide polymorphisms (SNPs) from a genome wide association study, strongly (P value < 5 × 10−8) and independently associated with erythrocyte copper and zinc. We applied these genetic predictors of copper and zinc to the largest, most extensively genotyped IHD case (n ≤ 76014)-control (n ≤ 264785) study, based largely on CARDIoGRAMplusC4D 1000 Genomes and the UK Biobank SOFT CAD, to obtain SNP-specific Wald estimates for the effects of copper and zinc on IHD, which were combined through the use of inverse variance weighting. Sensitivity analysis included use of the MR-Egger method, and reanalysis including SNPs independently associated with erythrocyte copper and zinc at P value < 5 × 10−6.ResultsGenetically instrumented copper was negatively associated with IHD (OR: 0.94; 95% CI: 0.90, 0.98). Genetically instrumented zinc was positively associated with IHD (OR: 1.06; 95% CI: 1.02, 1.11). Sensitivity analysis via MR-Egger gave no indication of unknown pleiotropy; less strongly associated SNPs gave similar results for copper.ConclusionGenetic validation of a long-standing hypothesis suggests that further investigation of the effects, particularly of copper, on IHD may provide a practical means of reducing the leading cause of mortality and morbidity.

scholarly journals SERUM LIPIDS AND LIPOPROTEIN IN HYPERTENSION AND ISCHEMIC HEART DISEASE

1967 ◽  
Vol 22 (3) ◽  
pp. 451-459
Author(s):  
Shigeo Koike ◽  
Michiko Komaya ◽  
Kenji Ikoma ◽  
Eiko Horiuchi ◽  
Tadataka Nagami
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Serum Lipids ◽  
Ischemic Heart

scholarly journals Seaweed intake and risk of cardiovascular disease: the Japan Public Health Center–based Prospective (JPHC) Study

2019 ◽  
Vol 110 (6) ◽  
pp. 1449-1455 ◽  
Author(s):  
Utako Murai ◽  
Kazumasa Yamagishi ◽  
Mizuki Sata ◽  
Yoshihiro Kokubo ◽  
Isao Saito ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Heart Disease ◽  
Cardiovascular Diseases ◽  
Ischemic Heart Disease ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Dietary Factors ◽  
Ischemic Heart ◽  
Daily Consumption ◽  
Ischemic Heart Disease Risk

ABSTRACT Background The minerals, vitamins, soluble dietary fibers, and flavonoids of seaweed are protective for preventing cardiovascular diseases. However, the association between seaweed intake and risk of cardiovascular disease has not been established. Objectives We examined the dietary intake of seaweed and its impact upon stroke and ischemic heart disease risk among a Japanese study population. Methods We surveyed 40,707 men and 45,406 women from 2 large cohorts (age range: 40–69 y). Seaweed intake was determined by FFQ at baseline (1990–1994). Incidences of stroke and ischemic heart disease were ascertained until the end of 2009 (Cohort I) or 2012 (Cohort II). Sex-specific cardiovascular disease HRs (95% CIs) were estimated using Cox proportional hazard models after stratification by area and adjustment for cardiovascular disease risk and dietary factors. Results During 1,493,232 person-years of follow-up, 4777 strokes (2863 ischemic stroke, 1361 intraparenchymal hemorrhages, and 531 subarachnoid hemorrhages) and 1204 ischemic heart disease cases were identified. Among men, significant multivariable HRs (95% CIs) for almost daily consumption compared with almost no consumption of seaweed were seen in ischemic heart disease [0.76 (0.58, 0.99); P-trend = 0.04] and total cardiovascular diseases [0.88 (0.78, 1.00); P-trend = 0.08]. Among women, such inverse associations were 0.56 (0.36, 0.85; P-trend = 0.006) for ischemic heart disease and 0.89 (0.76, 1.05; P-trend = 0.10) for total cardiovascular diseases. No significant associations were observed between seaweed intake and risk of total stroke or stroke types among either men or women. Conclusions Seaweed intake was inversely associated with risk of ischemic heart disease.

scholarly journals Serum Lipids Profiling Perturbances in Patients with Stable Ischemic Heart Disease and Ischemic Cardiomyopathy

2019 ◽  
Author(s):  
Lin Yang ◽  
Liang Wang ◽  
Yangyang Deng ◽  
Lizhe Sun ◽  
Bowen Low ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Ischemic Cardiomyopathy ◽  
Serum Lipids ◽  
Ischemic Heart ◽  
Negative Ion ◽  
Serum Samples ◽  
Cross Sectional ◽  
Negative Ion Mode ◽  
Positive Ion

Abstract Background: Ischemic heart disease(IHD) is a common cardiovascular disorder associated with inadequate blood supply to the myocardium. Chronic coronary ischemia leads to ischemic cardiomyopathy (ICM). Despite their rising prevalence and morbidity, few studies have discussed the lipids alterations in these patients. Methods: In this cross-sectional study, we analyzed serum lipids profile in IHD and ICM patients using a lipidomics approach. Consecutive patients admitted to the hospital for stable IHD and ICM were enrolled. Serum samples were obtained after overnight fasting. Nontargeted metabolomics was applied to demonstrate lipids metabolic profile in control, stable IHD and ICM patients. Results: A total of 63 and 62 lipids were detected in negative and positive ion mode respectively. Among them, 16:0 Lyso PI, 18:1 Lyso PI in negative ion mode, and 19:0 Lyso PC, 12:0 SM d18:1/12:0, 15:0 Lyso PC, 17:0 PC, 18:1-18:0 PC in positive ion mode were significantly altered both in IHD and ICM as compared to control. 13:0 Lyso PI, 18:0 Lyso PI, 16:0 PE, 14:0 PC DMPC, 16:0 ceramide, 18:0 ceramide in negative ion mode, and 17:0 PE, 19:0 PC, 14:0 Lyso PC, 20:0 Lyso PC, 18:0 PC DSPC, 18:0-22:6 PC in positive ion mode were significantly altered only in ICM as compared to IHD and control. Conclusion: Using non-targeted metabolomic profiling, we have successfully identified a group of circulating lipids that were significantly altered in stable IHD and ICM. The lipids metabolic signatures shed light on potential new biomarkers and therapeutics for preventing and treating ICM.

scholarly journals Serum Lipids Profiling Perturbance in Patients with Stable Ischemic Heart Disease and Ischemic Cardiomyopathy

2020 ◽  
Author(s):  
Lin Yang ◽  
Liang Wang ◽  
Yangyang Deng ◽  
Lizhe Sun ◽  
Bowen Low ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Ischemic Cardiomyopathy ◽  
Serum Lipids ◽  
Ischemic Heart ◽  
Negative Ion ◽  
Serum Samples ◽  
Cross Sectional ◽  
Negative Ion Mode ◽  
Positive Ion

Abstract Background: Ischemic heart disease(IHD) is a common cardiovascular disorder associated with inadequate blood supply to the myocardium. Chronic coronary ischemia leads to ischemic cardiomyopathy (ICM). Despite their rising prevalence and morbidity, few studies have discussed the lipids alterations in these patients. Methods: In this cross-sectional study, we analyzed serum lipids profile in IHD and ICM patients using a lipidomics approach. Consecutive patients admitted to the hospital for stable IHD and ICM were enrolled. Serum samples were obtained after overnight fasting. Nontargeted metabolomics was applied to demonstrate lipids metabolic profile in control, stable IHD and ICM patients. Results: A total of 63 and 62 lipids were detected in negative and positive ion mode respectively. Among them, 16:0 Lyso PI, 18:1 Lyso PI in negative ion mode, and 19:0 Lyso PC, 12:0 SM d18:1/12:0, 15:0 Lyso PC, 17:0 PC, 18:1-18:0 PC in positive ion mode were significantly altered both in IHD and ICM as compared to control. 13:0 Lyso PI, 18:0 Lyso PI, 16:0 PE, 14:0 PC DMPC, 16:0 ceramide, 18:0 ceramide in negative ion mode, and 17:0 PE, 19:0 PC, 14:0 Lyso PC, 20:0 Lyso PC, 18:0 PC DSPC, 18:0-22:6 PC in positive ion mode were significantly altered only in ICM as compared to IHD and control. Conclusion: Using non-targeted metabolomic profiling, we have successfully identified a group of circulating lipids that were significantly altered in stable IHD and ICM. The lipids metabolic signatures shed light on potential new biomarkers and therapeutics for preventing and treating ICM.

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