Creatinine Excretion as Index for Estimating Urinary Excretion of Micronutrients or Their Metabolic End Products

1970 ◽  
Vol 23 (7) ◽  
pp. 865-867 ◽  
Author(s):  
HERBERT POLLACK
Keyword(s):  
Urinary Excretion ◽  
Creatinine Excretion ◽  
End Products

scholarly journals Urinary excretion of amino acids and their advanced glycation end-products (AGEs) in adult kidney transplant recipients with emphasis on lysine: furosine excretion is associated with cardiovascular and all-cause mortality

Amino Acids ◽  
2021 ◽  
Author(s):  
Svetlana Baskal ◽  
Adrian Post ◽  
Daan Kremer ◽  
Alexander Bollenbach ◽  
Stephan J. L. Bakker ◽  
...  
Keyword(s):  
Amino Acids ◽  
Urinary Excretion ◽  
Excretion Rate ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
All Cause Mortality ◽  
Excretion Rates

AbstractArginine (Arg) and lysine (Lys) moieties of proteins undergo various post-translational modifications (PTM) including enzymatic NG- and Nε-methylation and non-enzymatic NG- and Nε-glycation. In a large cohort of stable kidney transplant recipients (KTR, n = 686), high plasma and low urinary concentrations of asymmetric dimethylarginine (ADMA), an abundant PTM metabolite of Arg, were associated with cardiovascular and all-cause mortality. Thus, the prediction of the same biomarker regarding mortality may depend on the biological sample. In another large cohort of stable KTR (n = 555), higher plasma concentrations of Nε-carboxymethyl-lysine (CML) and Nε-carboxyethyl-lysine (CEL), two advanced glycation end-products (AGEs) of Lys, were associated with higher cardiovascular mortality. Yet, the associations of urinary AGEs with mortality are unknown. In the present study, we measured 24 h urinary excretion of Lys, CML, and furosine in 630 KTR and 41 healthy kidney donors before and after donation. Our result indicate that lower urinary CML and lower furosine excretion rates are associated with higher mortality in KTR, thus resembling the associations of ADMA. Lower furosine excretion rates were also associated with higher cardiovascular mortality. The 24 h urinary excretion rate of amino acids and their metabolites decreased post-donation (varying as little as − 24% for CEL, and as much as − 62% for ADMA). For most amino acids, the excretion rate was lower in KTR than in donors pre-donation [except for S-(1-carboxyethyl)-l-cysteine (CEC) and NG-carboxyethylarginine (CEA)]. Simultaneous GC–MS measurement of free amino acids, their PTM metabolites and AGEs in urine is a non-invasive approach in kidney transplantation.

scholarly journals Supplemented Creatine Induces Changes in Human Metabolism of Thiocompounds and One- and Two-Carbon Units

2010 ◽  
pp. 431-442
Author(s):  
T Navrátil ◽  
E Kohlíková ◽  
M Petr ◽  
D Pelclová ◽  
M Heyrovský ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Vitamin B12 ◽  
Metabolic Pathways ◽  
Blood Levels ◽  
Redox Processes ◽  
Human Metabolism ◽  
Metabolic Disturbances ◽  
Creatinine Excretion ◽  
Thiodiglycolic Acid ◽  
The Last Man

The administration of creatine (5 g/day for one month) to 11 young active sportsmen affected their urinary excretion of creatine, creatinine, and thiodiglycolic acid (TDGA) as well as blood levels of homocysteine, vitamin B12 and folates. The probands were divided into four groups, according to the amount of creatine found in urine, and of folates and vitamin B12 determined in blood. The changes of folates and vitamin B12 were mutually reciprocal. Each group utilized CR as donor of one- and two-carbon (1C and 2C) units by means of homocysteine (HoCySH), folates, and vitamin B12, in different metabolic pathways. In 10 men the creatine administration was accompanied by an increase of HoCySH level in blood, while in the last man, with accidentally discovered hyperhomocysteinemia, the HoCySH level dropped by 50 %. Differences between initial and terminal TDGA levels indicate that creatine affects equilibria of redox processes. Creatinine excretion into urine changed in the dependence on the extent of metabolic disturbances.

scholarly journals Nitrogen balance in adult female mink (Mustela vison) in response to normal feeding andshort-term fasting

1997 ◽  
Vol 78 (1) ◽  
pp. 83-96 ◽  
Author(s):  
Anne-Helene Tauson ◽  
Jan Elnif ◽  
Søren Wamberg
Keyword(s):  
Urinary Excretion ◽  
Renal Clearance ◽  
Adult Female ◽  
Accurate Determination ◽  
Mustela Vison ◽  
Published Data ◽  
Purine Derivatives ◽  
Total N ◽  
Creatinine Excretion

Ten adult female mink (Mustela vison) were studied in a 7 d balance experiment consisting of a 2 d pre-surgery feeding period, followed by surgery, 1 d of recovery, 4 d of ad libitum feeding, and a 2d fasting period. In this experiment (Expt A) the animals had osmoticpumps implanted for continuous release of radioactively-labelled p–aminohippuric acid (p–aminobenzoyl-2-[3H]glycine; [3H]PAH;n10) and 14C-labelled inulin ([14C]IN; n 5). Repeated 24 h collections of urine, corrected to 100%[3H]PAH or [14C]IN recovery, were used for accurate determination of N balances, 24 h urinary excretion of urea, creatinine, and total N, and calculation of mean 24 h renal clearance rates for endogenous creatinine and inulin. N balances were slightly below zero, but not significantly different between feeding and fasting periods, indicating that correction to 100% [3H]PAH recovery resulted in slight overestimation of thefinal balances. During fasting, withdrawal of the dietary water and protein loads resulted in a dramatic decline in 24 h urinary volume, and urea and creatinine excretion. Large individualvariations in 24h urinary creatinine excretion (with relative variation coefficients up to 30%) confirmed that this is an unreliable index of the completeness of urine collection. In this respect, recovery rates of [3H]PAH proved far more consistent. Renal clearance values obtained in fed mink were in fair agreement with published data from cats, dogs and ferrets (Mustela putorius furo). Inulin clearance was about 30% higher than endogenous creatinine clearance, although its decline in response to fasting was not significant. In a separate study (Expt B)another ten female mink were equipped with osmotic pumps containing [3H]PAH for determination of 24 h excretion rates of purine derivatives. During feeding, allantoin accounted for more than 97 % of the excretion of purine derivatives in urine, uric acid making up less than 2·5%, xanthine and hypoxanthine less than 1 %. In fasted animals, urinary excretion of each of these purine derivatives declined to less than 50% of the feeding value. In conclusion, an experimental technique is presented for efficient and accurate measurements of daily urinary excretion of nitrogenous constituents, which allows for correct determination of N balances in adult mink and, presumably, in other mammalian species.

scholarly journals Studies on the role of taurine in Friedreich's ataxia

1984 ◽  
Vol 11 (S4) ◽  
pp. 610-615 ◽  
Author(s):  
B. Lemieux ◽  
R. Giguère ◽  
D. Shapcott
Keyword(s):  
Urinary Excretion ◽  
Muscle Mass ◽  
Friedreich’S Ataxia ◽  
Friedreich's Ataxia ◽  
Control Groups ◽  
Creatinine Excretion

AbstractNew studies were undertaken to verify the previous findings of increased urinary excretion of taurine, in the basal state and after challenge with a taurine load, in Friedreich's disease. Particular attention was paid to possible causes of error such as weight, muscle mass, creatine and creatinine excretion, variability with time and appropriate control groups. Although the overall findings were confirmed, their interpretation is open to question because of all these factors of error. Many possibilities must still be further explored to account for the apparent taurine retention defect observed in many cases of Friedreich's disease.

scholarly journals Urinary excretion of advanced glycation end products in dogs and cats

2020 ◽  
Author(s):  
Pornsucha Palaseweenun ◽  
Esther A. Hagen-Plantinga ◽  
J. Thomas Schonewille ◽  
Gerrit Koop ◽  
Claire Butre ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

Urinary excretion of fluorescent advanced glycation end products (AGEs) in the elderly

2008 ◽  
Vol 12 (3) ◽  
pp. 222-224 ◽  
Author(s):  
M. P. de la Maza ◽  
A. Bravo ◽  
L. Leiva ◽  
V. Gattas ◽  
G. Barrera ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Advanced Glycation End Products ◽  
The Elderly ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

Urinary excretion of polyamines: importance of circadian rhythm, age, sex, menstrual cycle, weight, and creatinine excretion

1990 ◽  
Vol 52 (4) ◽  
pp. 746-751 ◽  
Author(s):  
M J Pöyhönen ◽  
U M Uusitalo ◽  
A Kari ◽  
J A Takala ◽  
L A Alakuijala ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Menstrual Cycle ◽  
Urinary Excretion ◽  
Creatinine Excretion

Glycation in food and metabolic transit of dietary AGEs (advanced glycation end-products): studies on the urinary excretion of pyrraline

2003 ◽  
Vol 31 (6) ◽  
pp. 1383-1385 ◽  
Author(s):  
A. Foerster ◽  
T. Henle
Keyword(s):  
Urinary Excretion ◽  
Advanced Glycation End Products ◽  
Physiological Role ◽  
Dietary Control ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
First Time

Pyrraline [∊-(2´-formyl-5´-hydroxymethyl-pyrrolyl)-l-norleucin] belongs to the group of AGEs (advanced glycation end-products) formed in the final stage of the Maillard reaction in foods and in vivo. As it is generally accepted that AGEs are pathophysiologically relevant in aging and in diseases such as diabetes and uraemia, physiological consequences resulting from the ingestion of dietary AGEs are discussed, but balance studies for well defined AGEs are still lacking. The aim of our study was to investigate the influence of nutrition on the urinary excretion of pyrraline. After the first day without dietary restrictions, seven healthy volunteers were asked, starting on the morning of day 2, to ingest a diet virtually free of Maillard compounds (i.e. no cooked or roasted foods, no bakery products, no coffee, etc.). Dietary control was stopped on the morning of day 5. We collected 24 h urine samples for these 5 days, which were analysed for free pyrraline by reverse-phase HPLC with UV detection at 297 nm. We found that urinary excretion of free pyrraline was directly affected by the composition of the diet, decreasing from 4.8±1.1 mg/day on day 1 to levels of 1.6, 0.4 and 0.3 mg/day on days 2, 3 and 4 respectively, followed by a significant increase to 3.2±1.4 mg/day on the 5th day. The results of this work prove, for the first time, that urinary excretion of pyrraline is strongly dependent on its dietary intake. Thus the influence of nutrition should be taken into consideration in studies directed to the physiological role of glycation compounds.

Ultraviolet-absorbing Urinary Components of Mentally Retarded Children and Schizophrenic Adults

1968 ◽  
Vol 14 (5) ◽  
pp. 391-402 ◽  
Author(s):  
Adam W Lis ◽  
Roman Bijan ◽  
Elaine W Lis ◽  
Konrad F de Hackbeil
Keyword(s):  
Urinary Excretion ◽  
Nicotinic Acid ◽  
Ultraviolet Light ◽  
Mentally Retarded ◽  
Pyrimidine Metabolism ◽  
Control Subjects ◽  
End Products ◽  
Mentally Retarded Children ◽  
Derivatives Of

Abstract Urinary excretion of ultraviolet-light-absorbing end products of metabolism was studied in mentally retarded children and schizophrenic adults. Excretion of the major end product of pyrimidine metabolism, pseudouridine (5-ribosyluracil), and one of the catabolic derivatives of nicotinic acid, N-methyl-2-pyridone-5-carboxamide, were both found to be depressed in more than half the mentally retarded children and all the schizophrenic adults studied. In addition, a number of previously unidentified components have been found in both types of mental abnormality, as well as in control subjects, some of which components appear to be present in abnormal quantities.

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