Comparison of the effects of keto acid analogues and essential amino acids on nitrogen homeostasis in uremic patients on moderately protein-restricted diets

1978 ◽  
Vol 31 (10) ◽  
pp. 1767-1775 ◽  
Author(s):  
J Burns ◽  
E Cresswell ◽  
S Ell ◽  
M Fynn ◽  
M A Jackson ◽  
...  
Keyword(s):  
Amino Acids ◽  
Essential Amino Acids ◽  
Keto Acid ◽  
Uremic Patients

scholarly journals The case for regulating indispensable amino acid metabolism: the branched-chain α-keto acid dehydrogenase kinase-knockout mouse

2006 ◽  
Vol 400 (1) ◽  
Author(s):  
Susan M. Hutson
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Essential Amino Acids ◽  
The Body ◽  
Keto Acid ◽  
Acid Dehydrogenase ◽  
Indispensable Amino Acid ◽  
Branched Chain

BCAAs (branched-chain amino acids) are indispensable (essential) amino acids that are required for body protein synthesis. Indispensable amino acids cannot be synthesized by the body and must be acquired from the diet. The BCAA leucine provides hormone-like signals to tissues such as skeletal muscle, indicating overall nutrient sufficiency. BCAA metabolism provides an important transport system to move nitrogen throughout the body for the synthesis of dispensable (non-essential) amino acids, including the neurotransmitter glutamate in the central nervous system. BCAA metabolism is tightly regulated to maintain levels high enough to support these important functions, but at the same time excesses are prevented via stimulation of irreversible disposal pathways. It is well known from inborn errors of BCAA metabolism that dysregulation of the BCAA catabolic pathways that leads to excess BCAAs and their α-keto acid metabolites results in neural dysfunction. In this issue of Biochemical Journal, Joshi and colleagues have disrupted the murine BDK (branched-chain α-keto acid dehydrogenase kinase) gene. This enzyme serves as the brake on BCAA catabolism. The impaired growth and neurological abnormalities observed in this animal show conclusively the importance of tight regulation of indispensable amino acid metabolism.

Effects of a Low Phosphorus, Low Nitrogen Diet Supplemented with Essential Amino Acids and Ketoanalogues on Serum Triglycerides of Chronic Uremic Patients

Nephron ◽  
1986 ◽  
Vol 42 (3) ◽  
pp. 196-199 ◽  
Author(s):  
F. Ciardella ◽  
E. Morelli ◽  
F. Niosi ◽  
R. Caprioli ◽  
R. Baldi ◽  
...  
Keyword(s):  
Amino Acids ◽  
Essential Amino Acids ◽  
Serum Triglycerides ◽  
Low Phosphorus ◽  
Uremic Patients ◽  
Low Nitrogen

Use of Essential Amino Acids in Uremic Patients

1976 ◽  
Vol 20 (1) ◽  
pp. 48-56 ◽  
Author(s):  
H. Gofferje
Keyword(s):  
Amino Acids ◽  
Essential Amino Acids ◽  
Uremic Patients

Evaluation of essential amino acids and keto acids in uremic patients on low-protein diet

1978 ◽  
Vol 31 (10) ◽  
pp. 1784-1792 ◽  
Author(s):  
A Heidland ◽  
J Kult ◽  
A Röckel ◽  
E Heidbreder
Keyword(s):  
Amino Acids ◽  
Essential Amino Acids ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein ◽  
Keto Acids ◽  
Uremic Patients
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