Energy expenditure and body composition during weight reduction in hyperplastic obese women

1978 ◽  
Vol 31 (5) ◽  
pp. 750-763 ◽  
Author(s):  
I Warnold ◽  
G Carlgren ◽  
M Krotkiewski
1995 ◽  
Vol 61 (3) ◽  
pp. 486-494 ◽  
Author(s):  
S B Racette ◽  
D A Schoeller ◽  
R F Kushner ◽  
K M Neil ◽  
K Herling-Iaffaldano

2020 ◽  
Vol 105 (4) ◽  
pp. e1741-e1748 ◽  
Author(s):  
Emanuele Muraca ◽  
Stefano Ciardullo ◽  
Alice Oltolini ◽  
Francesca Zerbini ◽  
Eleonora Bianconi ◽  
...  

Abstract Context Growing evidence suggests that appropriate levothyroxine (LT4) replacement therapy may not correct the full set of metabolic defects afflicting individuals with hypothyroidism. Objective To assess whether obese subjects with primary hypothyroidism are characterized by alterations of the resting energy expenditure (REE). Design Retrospective analysis of a set of data about obese women attending the outpatients service of a single obesity center from January 2013 to July 2019. Patients A total of 649 nondiabetic women with body mass index (BMI) > 30 kg/m2 and thyrotropin (TSH) level 0.4–4.0 mU/L were segregated into 2 groups: patients with primary hypothyroidism taking LT4 therapy (n = 85) and patients with normal thyroid function (n = 564). Main outcomes REE and body composition assessed using indirect calorimetry and bioimpedance. Results REE was reduced in women with hypothyroidism in LT4 therapy when compared with controls (28.59 ± 3.26 vs 29.91 ± 3.59 kcal/kg fat-free mass (FFM)/day), including when adjusted for age, BMI, body composition, and level of physical activity (P = 0.008). This metabolic difference was attenuated only when adjustment for homeostatic model assessment of insulin resistance (HOMA-IR) was performed. Conclusions This study demonstrated that obese hypothyroid women in LT4 therapy, with normal serum TSH level compared with euthyroid controls, are characterized by reduced REE, in line with the hypothesis that standard LT4 replacement therapy may not fully correct metabolic alterations related to hypothyroidism. We are not able to exclude that this feature may be influenced by the modulation of insulin sensitivity at the liver site, induced by LT4 oral administration.


2000 ◽  
Vol 24 (12) ◽  
pp. 1567-1572 ◽  
Author(s):  
L Karhunen ◽  
A Franssila-Kallunki ◽  
P Rissanen ◽  
R Valve ◽  
M Kolehmainen ◽  
...  

Metabolism ◽  
1992 ◽  
Vol 41 (7) ◽  
pp. 686-688 ◽  
Author(s):  
Arne Astrup ◽  
Benjamin Buemann ◽  
Niels Juel Christensen ◽  
Søren Toubro ◽  
Grete Thorbek ◽  
...  

Appetite ◽  
2007 ◽  
Vol 49 (3) ◽  
pp. 635-643 ◽  
Author(s):  
Eliane Lopes Rosado ◽  
Josefina Bressan ◽  
Marta F. Martins ◽  
Paulo R. Cecon ◽  
Jose Alfredo Martínez

1995 ◽  
Vol 25 (1) ◽  
pp. 195-198 ◽  
Author(s):  
G. F. Adami ◽  
P. Gandolfo ◽  
A. Campostano ◽  
F. Cocchi ◽  
B. Bauer ◽  
...  

SynopsisThe study was carried out in two groups of massively obese women with BMI values who were to undergo bariatric surgery. The patients were evaluated for weight variability and for the presence and the frequency of binge eating. Body composition, resting energy expenditure (REE) and metabolic parameters were also measured. When non-bingeing individuals were compared with patients who met Binge Eating Disorder criteria, no differences in body composition, fat distribution, REE values and concentrations of serum lipids, insulin and thyroid hormones were found. On the other hand, weight variability due to reduced diet in the subjects' lifetime was significantly higher. This study does not support the hypothesis that in massively obese women binge eating is somehow induced by a reduced energy expenditure.


2004 ◽  
Vol 287 (3) ◽  
pp. E472-E479 ◽  
Author(s):  
Ndubueze C. Okereke ◽  
Larraine Huston-Presley ◽  
Saeid B. Amini ◽  
Satish Kalhan ◽  
Patrick M. Catalano

Our primary objective was to evaluate changes in energy expenditure and body composition in women with normal glucose tolerance (NGT) and gestational diabetes mellitus (GDM). A secondary objective was to examine the relationship between maternal leptin and nutrient metabolism. Fifteen obese women, eight with NGT and seven with GDM, were evaluated before conception (P), at 12–14 wk (E), and at 34–36 wk (L). Energy expenditure and glucose and fat metabolism were measured using indirect calorimetry. Basal hepatic glucose production was measured using [6,6-2H2]glucose and insulin sensitivity by euglycemic clamp. There was a significant increase (6.6 kg, P = 0.0001) in fat mass from P to L. There was a 30% ( P = 0.0001) increase in basal O2 consumprion (V̇o2, ml/min). There were no significant changes in carbohydrate oxidation during fasting or storage from P to L. There was, however, a significant ( P = 0.0001) 150% increase in basal fat oxidation (mg/min) from P to L. Under hyperinsulinemic conditions, there were similar 25% increases in V̇o2 ( P = 0.0001) from P to L in both groups. Because of the significant increases in insulin resistance from P to L, there was a significant ( P = 0.0001) decrease in carbohydrate oxidation and storage. There was a net change from lipogenesis to lipolysis, i.e., fat oxidation (30–40 mg/min, P = 0.0001) from P to L. Serum leptin concentrations had a significant positive correlation with fat oxidation at E ( r = 0.76, P = 0.005) and L ( r = 0.72, P = 0.009). Pregnancy in obese women is associated with significant increases in fat mass and basal metabolic rate and an increased reliance on lipids both in the basal state and during the clamp. These modifications are similar in women with NGT and GDM. The increased reliance on fat metabolism is accompanied by a concomitant decrease in carbohydrate metabolism during hyperinsulinemia. The increase in fat oxidation may be related to increased maternal serum leptin.


2002 ◽  
Vol 282 (4) ◽  
pp. E923-E930 ◽  
Author(s):  
S. B. Votruba ◽  
S. Blanc ◽  
D. A. Schoeller

Weight gain is common among postobese individuals, providing an opportunity to address the cost of weight regain on energy expenditure. We investigated the energy cost of weight regain over 1 yr in 28 women [age 39.5 ± 1.3 (SE) yr; body mass index 24.2 ± 0.5 kg/m2] with recent weight loss (>12 kg). Body composition, total energy expenditure (TEE) using doubly labeled water, resting metabolic rate (RMR), and thermic effect of a meal (TEM) were assessed at 0 and 12 mo. Metabolizable energy intake (MEI) was calculated from TEE and change in body composition. Fourteen women had a weight gain of 13.2 ± 2.1 kg. Twelve-month cumulative excess MEI, calculated as the intake in excess of TEE at month 0, was 749 ± 149 MJ. Of this, 462 ± 83 MJ (62%) were stored as accrued tissue, and 287 ± 72 MJ (38%) was increased TEE. Expressed per kilogram of body weight gain, the energy cost of weight gain was calculated to be 54.8 ± 4.6 MJ/kg. Interestingly, weight regain time courses fell into three distinct patterns, possibly requiring varying countermeasures.


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