Effect of weight reduction on resting energy expenditure, substrate utilization, and the thermic effect of food in moderately obese women

1992 ◽  
Vol 55 (5) ◽  
pp. 924-933 ◽  
Author(s):  
K M Nelson ◽  
R L Weinsier ◽  
L D James ◽  
B Darnell ◽  
G Hunter ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Weight Reduction ◽  
Resting Energy Expenditure ◽  
Substrate Utilization ◽  
Obese Women ◽  
Thermic Effect Of Food ◽  
Effect Of Food ◽  
Thermic Effect ◽  
Resting Energy

Changes in body composition, resting energy expenditure, and thermic effect of food in short children on growth hormone therapy

Metabolism ◽  
1994 ◽  
Vol 43 (12) ◽  
pp. 1543-1548 ◽  
Author(s):  
Nachum Vaisman ◽  
Zvi Zadik ◽  
Alla Akivias ◽  
Hillary Voet ◽  
Inbal Katz ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Body Composition ◽  
Energy Expenditure ◽  
Hormone Therapy ◽  
Growth Hormone Therapy ◽  
Resting Energy Expenditure ◽  
Short Children ◽  
Thermic Effect Of Food ◽  
Effect Of Food ◽  
Thermic Effect

Role of thermogenesis in the regulation of energy balance in relation to obesity

1989 ◽  
Vol 67 (4) ◽  
pp. 394-401 ◽  
Author(s):  
Jean Himms-Hagen
Keyword(s):  
Adipose Tissue ◽  
Energy Balance ◽  
Energy Expenditure ◽  
Brown Adipose Tissue ◽  
Thermal Balance ◽  
Prominent Feature ◽  
Thermic Effect Of Food ◽  
Brown Adipose ◽  
Effect Of Food ◽  
Thermic Effect

Obligatory thermogenesis is a necessary accompaniment of all metabolic processes involved in maintenance of the body in the living state, and occurs in ail organs. It includes energy expenditure involved in ingesting, digesting, and processing food (thermic effect of food (TEF)). At certain life stages extra energy expenditure for growth, pregnancy, or lactation would also be obligatory. Facultative thermogenesis is superimposed on obligatory thermogenesis and can be rapidly switched on and rapidly suppressed by the nervous system. Facultative thermogenesis is important in both thermal balance, in which control of thermoregulatory thermogenesis (shivering in muscle, nonshivering in brown adipose tissue (BAT)) balances neural control of heat loss mechanisms, and in energy balance, in which control of facultative thermogenesis (exercise-induced in muscle, diet-induced thermogenesis (DIT) in BAT) balances control of energy intake. Thermal balance (i.e., body temperature) is much more stringently controlled than energy balance (i.e., body energy stores). Reduced energy expenditure for thermogenesis is important in two types of obesity in laboratory animals. In the first type, deficient DIT in BAT is a prominent feature of altered energy balance. It may or may not be associated with hyperphagia. In a second type, reduced cold-induced thermogenesis in BAT as well as in other organs is a prominent feature of altered thermal balance. This in turn results in altered energy balance and obesity, exacerbated in some examples by hyperphagia. In some of the hyperphagic obese animals it is likely that the exaggerated obligatory thermic effect of food so alters thermal balance that BAT thermogenesis is suppressed. In all obese animals, deficient hypothalamic control of facultative thermogenesis and (or) food intake is implicated.Key words: thermogenesis, brown adipose tissue, energy balance, obesity, cold, thermoregulation, diet.

Resting Energy Expenditure in Obese Women with Primary Hypothyroidism and Appropriate Levothyroxine Replacement Therapy

2020 ◽  
Vol 105 (4) ◽  
pp. e1741-e1748 ◽  
Author(s):  
Emanuele Muraca ◽  
Stefano Ciardullo ◽  
Alice Oltolini ◽  
Francesca Zerbini ◽  
Eleonora Bianconi ◽  
...  
Keyword(s):  
Body Composition ◽  
Energy Expenditure ◽  
Replacement Therapy ◽  
Resting Energy Expenditure ◽  
Primary Hypothyroidism ◽  
Normal Serum ◽  
Fat Free Mass ◽  
Model Assessment ◽  
Obese Women ◽  
Resting Energy

Abstract Context Growing evidence suggests that appropriate levothyroxine (LT4) replacement therapy may not correct the full set of metabolic defects afflicting individuals with hypothyroidism. Objective To assess whether obese subjects with primary hypothyroidism are characterized by alterations of the resting energy expenditure (REE). Design Retrospective analysis of a set of data about obese women attending the outpatients service of a single obesity center from January 2013 to July 2019. Patients A total of 649 nondiabetic women with body mass index (BMI) > 30 kg/m2 and thyrotropin (TSH) level 0.4–4.0 mU/L were segregated into 2 groups: patients with primary hypothyroidism taking LT4 therapy (n = 85) and patients with normal thyroid function (n = 564). Main outcomes REE and body composition assessed using indirect calorimetry and bioimpedance. Results REE was reduced in women with hypothyroidism in LT4 therapy when compared with controls (28.59 ± 3.26 vs 29.91 ± 3.59 kcal/kg fat-free mass (FFM)/day), including when adjusted for age, BMI, body composition, and level of physical activity (P = 0.008). This metabolic difference was attenuated only when adjustment for homeostatic model assessment of insulin resistance (HOMA-IR) was performed. Conclusions This study demonstrated that obese hypothyroid women in LT4 therapy, with normal serum TSH level compared with euthyroid controls, are characterized by reduced REE, in line with the hypothesis that standard LT4 replacement therapy may not fully correct metabolic alterations related to hypothyroidism. We are not able to exclude that this feature may be influenced by the modulation of insulin sensitivity at the liver site, induced by LT4 oral administration.

Effect of Weight Loss on Resting Energy Expenditure in Hypertensive and Normotensive Obese Women

1998 ◽  
Vol 20 (4) ◽  
pp. 403-416 ◽  
Author(s):  
Wayne H-H Sheu ◽  
H-M Linda Chin ◽  
H-Y Su ◽  
C-Y Jeng
Keyword(s):  
Weight Loss ◽  
Energy Expenditure ◽  
Resting Energy Expenditure ◽  
Obese Women ◽  
Resting Energy
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